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    FAM156B family with sequence similarity 156 member B [ Homo sapiens (human) ]

    Gene ID: 727866, updated on 28-Oct-2024

    Summary

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    Official Symbol
    FAM156Bprovided by HGNC
    Official Full Name
    family with sequence similarity 156 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:31962
    See related
    Ensembl:ENSG00000179304 AllianceGenome:HGNC:31962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMEM29B
    Summary
    Predicted to enable methylated histone binding activity. Located in nuclear envelope. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in skin (RPKM 23.6), placenta (RPKM 20.7) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See FAM156B in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (52891592..52908560)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (52176499..52193446)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (52920622..52937587)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29644 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:52895119-52896318 Neighboring gene X antigen family member 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:52949629-52950232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29647 Neighboring gene uncharacterized LOC124905190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29649 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:52963212-52964184 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:52964185-52965156 Neighboring gene family with sequence similarity 156 member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53018839-53019418

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk. Tian T, et al. Cancer Med, 2021 Jul. PMID 34145793, Free PMC Article
    2. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. Chen YT, et al. Genes Chromosomes Cancer, 2006 Apr. PMID 16382448
    3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    4. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. Simpson JC, et al. EMBO Rep, 2000 Sep. PMID 11256614, Free PMC Article
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk.
      Title: Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ33130, FLJ34279, FLJ38843, DKFZp686H1294

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables methylated histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM156A/FAM156B
    Names
    protein FAM156A
    transmembrane protein 29
    transmembrane protein 29/29B
    transmembrane protein 29B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099684.2 → NP_001093154.1  protein FAM156A/FAM156B

      See identical proteins and their annotated locations for NP_001093154.1

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS43957.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000422411.1, ENST00000509613.1
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    2. NM_001321178.3 → NP_001308107.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS43957.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000424864.1, ENST00000416841.8
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    3. NM_001321179.2 → NP_001308108.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS43957.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000469248.1, ENST00000593751.7
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    4. NM_001321180.1 → NP_001308109.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS43957.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    5. NM_001321181.2 → NP_001308110.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS43957.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    6. NM_001321182.2 → NP_001308111.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS43957.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Related
      ENSP00000483008.1, ENST00000616419.4
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    7. NM_001321183.1 → NP_001308112.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS43957.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    8. NM_001321186.2 → NP_001308115.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS43957.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    9. NM_001321187.2 → NP_001308116.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS43957.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    10. NM_001321188.1 → NP_001308117.1  protein FAM156A/FAM156B

      Status: VALIDATED

      Source sequence(s)
      AC234031
      Consensus CDS
      CCDS43957.1
      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      52891592..52908560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442415.1 → XP_047298371.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    2. XM_047442416.1 → XP_047298372.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    3. XM_011530817.2 → XP_011529119.1  protein FAM156A/FAM156B isoform X1

      See identical proteins and their annotated locations for XP_011529119.1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
      UniProtKB/TrEMBL
      A0A087WVC8
      Conserved Domains (1) summary
      pfam15549
      Location:1 → 170
      PGC7_Stella; PGC7/Stella/Dppa3 domain

    4. XM_047442417.1 → XP_047298373.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      52176499..52193446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327677.1 → XP_054183652.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    2. XM_054327678.1 → XP_054183653.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    3. XM_054327676.1 → XP_054183651.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49

    4. XM_054327679.1 → XP_054183654.1  protein FAM156A/FAM156B isoform X1

      UniProtKB/Swiss-Prot
      B3KQ92, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q8NDB6, Q9UI49
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NDB6.1 GenPept UniProtKB/Swiss-Prot:Q8NDB6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials