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    Nptxr neuronal pentraxin receptor [ Mus musculus (house mouse) ]

    Gene ID: 73340, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nptxrprovided by MGI
    Official Full Name
    neuronal pentraxin receptorprovided by MGI
    Primary source
    MGI:MGI:1920590
    See related
    Ensembl:ENSMUSG00000022421 AllianceGenome:MGI:1920590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NPR; Npcd; D15Bwg0580e; 1200009K17Rik; 1700036C17Rik; 5730406O18Rik
    Summary
    This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in frontal lobe adult (RPKM 79.6), cortex adult (RPKM 75.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nptxr in Genome Data Viewer
    Location:
    15 E1; 15 37.85 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79670552..79688910, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79786351..79804709, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, light chain 4 Neighboring gene STARR-positive B cell enhancer ABC_E390 Neighboring gene predicted gene, 30977 Neighboring gene predicted gene, 57816 Neighboring gene neuronal pentraxin chromo domain Neighboring gene chromobox 6 Neighboring gene predicted gene 10856

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Therapeutic monoclonal antibody targeting of neuronal pentraxin receptor to control metastasis in gastric cancer. Kanda M, et al. Mol Cancer, 2020 Aug 26. PMID 32847597, Free PMC Article
    2. Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons. Pelkey KA, et al. Neuron, 2015 Mar 18. PMID 25754824, Free PMC Article
    3. Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment. Sia GM, et al. Neuron, 2007 Jul 5. PMID 17610819
    4. Neuronal pentraxins mediate synaptic refinement in the developing visual system. Bjartmar L, et al. J Neurosci, 2006 Jun 7. PMID 16763034, Free PMC Article
    5. mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE. Cho RW, et al. Neuron, 2008 Mar 27. PMID 18367087, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We find that NPR is a potent inducer of both excitatory and inhibitory heterologous synapses, and that knockdown of NPR in cultured neurons decreases the density of both excitatory and inhibitory synapses
      Title: Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses.
    2. Early postnatal NPTX2(-/-)/NPTXR(-/-) mice exhibit delayed circuit maturation with a prolonged critical period permissive for giant depolarizing potentials
      Title: Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.
    3. non-AUG translation initiation site. Comparison of rat determined N-terminal amino acid sequence with cDNA sequence indicates that a CUG codon is used as an initiator codon and codes for a methionine. The CTG is present in cDNAs of mouse, rat, and human.
      Title: Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough Npcd

    Readthrough gene: Npcd, Included gene: Cbx6

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pentraxin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic specialization assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic specialization assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuronal pentraxin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030689.4 → NP_109614.2  neuronal pentraxin receptor precursor

      Status: REVIEWED

      Source sequence(s)
      AC118227, BC058962
      Consensus CDS
      CCDS27653.1
      UniProtKB/Swiss-Prot
      Q99J85
      UniProtKB/TrEMBL
      A0A9R1SP20, B9EIV5
      Related
      ENSMUSP00000023057.10, ENSMUST00000023057.10
      Conserved Domains (1) summary
      smart00159
      Location:281 → 487
      PTX; Pentraxin / C-reactive protein / pentaxin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79670552..79688910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99J85.1 GenPept UniProtKB/Swiss-Prot:Q99J85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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