Usp45 ubiquitin specific petidase 45 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp45provided by MGI
Official Full Name: ubiquitin specific petidase 45provided by MGI
Primary source: MGI:MGI:101850
See related: Ensembl:ENSMUSG00000040455 AllianceGenome:MGI:101850
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gcap7; 3110003C05Rik; 4930550B20Rik
Summary: Predicted to enable cysteine-type deubiquitinase activity. Involved in photoreceptor cell maintenance. Predicted to be located in cytosol; nucleoplasm; and photoreceptor inner segment. Used to study Leber congenital amaurosis 19. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 19. Orthologous to human USP45 (ubiquitin specific peptidase 45). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 6.8), liver E14.5 (RPKM 5.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A3; 4 8.93 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (21767161..21837872)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (21767161..21837872)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results establish USP45 as a new regulator of XPF-ERCC1 crucial for efficient DNA repair
Title: USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU015084 (e-PCR)
- UniSTS:178973

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AI843191 (e-PCR)
- UniSTS:164231

AU015084 (e-PCR)
- UniSTS:207604

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural retina development	ISS Inferred from Sequence or Structural Similarity more info
involved_in photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein deubiquitination	ISO Inferred from Sequence Orthology more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 45

Names: deubiquitinating enzyme 45; granule cell antiserum positive 7; ubiquitin specific protease 45; ubiquitin thioesterase 45; ubiquitin thiolesterase 45; ubiquitin-specific-processing protease 45

NP_001277354.1

EC 3.4.19.12

NP_690038.1

EC 3.4.19.12

XP_006538424.1

EC 3.4.19.12

XP_006538425.1

EC 3.4.19.12

XP_011248434.1

EC 3.4.19.12

XP_030109769.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290425.1 → NP_001277354.1 ubiquitin carboxyl-terminal hydrolase 45 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AI465456, AK019756, AL772187, BB213271

Consensus CDS

CCDS71351.1

UniProtKB/Swiss-Prot

Q8K387

Related

ENSMUSP00000048324.6, ENSMUST00000040429.12

Conserved Domains (3) summary

cd02667
Location:192 → 762

Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:192 → 761

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam02148
Location:62 → 132

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
NM_152825.2 → NP_690038.1 ubiquitin carboxyl-terminal hydrolase 45 isoform 1

See identical proteins and their annotated locations for NP_690038.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AI465456, AK019756, AK040660, AL772187, BM227454

Consensus CDS

CCDS38700.1

UniProtKB/Swiss-Prot

A2AJT1, Q8BU19, Q8BZ19, Q8K387

Related

ENSMUSP00000067109.9, ENSMUST00000065111.15

Conserved Domains (3) summary

COG5207
Location:72 → 359

UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]

cd02667
Location:587 → 810

Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:192 → 388

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

21767161..21837872

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250132.1 → XP_011248434.1 ubiquitin carboxyl-terminal hydrolase 45 isoform X1

See identical proteins and their annotated locations for XP_011248434.1

UniProtKB/Swiss-Prot

A2AJT1, Q8BU19, Q8BZ19, Q8K387

Conserved Domains (3) summary

COG5207
Location:72 → 359

UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]

cd02667
Location:587 → 810

Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:192 → 388

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
XM_006538362.1 → XP_006538425.1 ubiquitin carboxyl-terminal hydrolase 45 isoform X2

Conserved Domains (3) summary

COG5207
Location:71 → 358

UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]

cd02667
Location:586 → 809

Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:191 → 387

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
XM_030253909.1 → XP_030109769.1 ubiquitin carboxyl-terminal hydrolase 45 isoform X3

Conserved Domains (3) summary

COG5560
Location:192 → 713

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cl02553
Location:192 → 388

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam02148
Location:62 → 132

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
XM_006538361.5 → XP_006538424.1 ubiquitin carboxyl-terminal hydrolase 45 isoform X1

See identical proteins and their annotated locations for XP_006538424.1

UniProtKB/Swiss-Prot

A2AJT1, Q8BU19, Q8BZ19, Q8K387

Conserved Domains (3) summary

COG5207
Location:72 → 359

UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]

cd02667
Location:587 → 810

Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:192 → 388

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...