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    ZYG11B zyg-11 family member B, cell cycle regulator [ Homo sapiens (human) ]

    Gene ID: 79699, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ZYG11Bprovided by HGNC
    Official Full Name
    zyg-11 family member B, cell cycle regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:25820
    See related
    Ensembl:ENSG00000162378 MIM:618673; AllianceGenome:HGNC:25820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZYG11
    Summary
    Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 12.1), thyroid (RPKM 8.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZYG11B in Genome Data Viewer
    Location:
    1p32.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (52726453..52827336)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (52607957..52708870)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53192125..53293008)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 62, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 898 Neighboring gene RNA, U2 small nuclear 30, pseudogene Neighboring gene ribosomal protein S13 pseudogene 2 Neighboring gene RNA, U6 small nuclear 969, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11599 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:53297677-53298444 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53301449-53302130 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53302131-53302812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53309013-53309606 Neighboring gene zyg-11 family member A, cell cycle regulator Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53334860-53335744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53335745-53336627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53370741-53371532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53372219-53372718 Neighboring gene Sharpr-MPRA regulatory region 4702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53377381-53377881 Neighboring gene enoyl-CoA hydratase domain containing 2 Neighboring gene translation machinery-associated protein 7-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53387115-53387797

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites. Zhu K, et al. Acta Pharm Sin B, 2024 Sep. PMID 39309499, Free PMC Article
    2. A close shave: How SARS-CoV-2 induces the loss of cilia. Fonseca BF, et al. J Cell Biol, 2022 Jul 4. PMID 35695891, Free PMC Article
    3. Structural insights into ORF10 recognition by ZYG11B. Zhang B, et al. Biochem Biophys Res Commun, 2022 Aug 6. PMID 35636250, Free PMC Article
    4. LncRNA LINC01871 sponging miR-142-3p to modulate ZYG11B promotes the chemoresistance of colorectal cancer cells by inducing autophagy. Duan B, et al. Anticancer Drugs, 2023 Aug 1. PMID 36847071, Free PMC Article
    5. CRL2(ZER1/ZYG11B) recognizes small N-terminal residues for degradation. Li Y, et al. Nat Commun, 2022 Dec 10. PMID 36496439, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA LINC01871 sponging miR-142-3p to modulate ZYG11B promotes the chemoresistance of colorectal cancer cells by inducing autophagy.
      Title: LncRNA LINC01871 sponging miR-142-3p to modulate ZYG11B promotes the chemoresistance of colorectal cancer cells by inducing autophagy.
    2. Structural insights into ORF10 recognition by ZYG11B.
      Title: Structural insights into ORF10 recognition by ZYG11B.
    3. A close shave: How SARS-CoV-2 induces the loss of cilia.
      Title: A close shave: How SARS-CoV-2 induces the loss of cilia.
    4. Molecular basis for recognition of Gly/N-degrons by CRL2(ZYG11B) and CRL2(ZER1).
      Title: Molecular basis for recognition of Gly/N-degrons by CRL2(ZYG11B) and CRL2(ZER1).
    5. Functional and genetic analyses of ZYG11B provide evidences for its involvement in OAVS.
      Title: Functional and genetic analyses of ZYG11B provide evidences for its involvement in OAVS.
    6. ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
      Title: ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
    7. the ubiquitin ligase CRL2(ZYG-11) redundantly targets the degradation of cyclin B1 in Caenorhabditis elegans and human cells.
      Title: The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13456

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein quality control for misfolded or incompletely synthesized proteins IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein zyg-11 homolog B
    Names
    zyg-11 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024646.3 → NP_078922.1  protein zyg-11 homolog B

      See identical proteins and their annotated locations for NP_078922.1

      Status: VALIDATED

      Source sequence(s)
      AB051517, AC099784, AK296460, AL139255
      Consensus CDS
      CCDS30717.1
      UniProtKB/Swiss-Prot
      Q8N2X3, Q9C0D3, Q9H8L8
      UniProtKB/TrEMBL
      B3KTI5
      Related
      ENSP00000294353.6, ENST00000294353.7
      Conserved Domains (2) summary
      sd00034
      Location:188 → 213
      LRR_AMN1; leucine-rich repeat [structural motif]
      NF033190
      Location:143 → 248
      inl_like_NEAT_1; NEAT domain-containing leucine-rich repeat protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      52726453..52827336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002336.3 → XP_016857825.1  protein zyg-11 homolog B isoform X2

      UniProtKB/TrEMBL
      A8DPD7
      Related
      ENSP00000441315.1, ENST00000545132.5
      Conserved Domains (1) summary
      sd00034
      Location:188 → 213
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. XM_006710898.5 → XP_006710961.1  protein zyg-11 homolog B isoform X1

      UniProtKB/TrEMBL
      B3KTI5
      Conserved Domains (3) summary
      cd00020
      Location:489 → 607
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00116
      Location:173 → 295
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:184 → 209
      LRR_AMN1; leucine-rich repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      52607957..52708870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338747.1 → XP_054194722.1  protein zyg-11 homolog B isoform X2

      UniProtKB/TrEMBL
      A8DPD7

    2. XM_054338746.1 → XP_054194721.1  protein zyg-11 homolog B isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C0D3.2 GenPept UniProtKB/Swiss-Prot:Q9C0D3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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