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    FBP1 fructose 1,6-bisphosphate 1-phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851092, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FBP1
    Official Full Name
    fructose 1,6-bisphosphate 1-phosphatase
    Primary source
    SGD:S000004369
    Locus tag
    YLR377C
    See related
    AllianceGenome:SGD:S000004369; FungiDB:YLR377C; VEuPathDB:YLR377C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ACN8
    Summary
    Enables fructose 1,6-bisphosphate 1-phosphatase activity. Involved in gluconeogenesis and reactive oxygen species metabolic process. Located in cytosol and periplasmic space. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1) and FBP2 (fructose-bisphosphatase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See FBP1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (873746..874792, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Stp3p Neighboring gene Psy3p Neighboring gene tRNA-Lys Neighboring gene translocon subunit SEC61

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cpFBPaseII, a novel redox-independent chloroplastic isoform of fructose-1,6-bisphosphatase. Serrato AJ, et al. Plant Cell Environ, 2009 Jul. PMID 19220782
    2. Isolation and characterization of a mutant from Saccharomyces cerevisiae lacking fructose 1,6-bisphosphatase. Gancedo C, et al. Eur J Biochem, 1984 Mar 15. PMID 6321183
    3. Fructose 2,6-bisphosphate activates the cAMP-dependent phosphorylation of yeast fructose-1,6-bisphosphatase in vitro. Gancedo JM, et al. J Biol Chem, 1983 May 25. PMID 6304022
    4. Inactivation of yeast fructose-1,6-bisphosphatase. In vivo phosphorylation of the enzyme. Mazón MJ, et al. J Biol Chem, 1982 Feb 10. PMID 6276373
    5. Sensitivity of fructose-1,6-biphosphatase from yeast, liver and skeletal muscle to fructose-2,6-biphosphate and 5'-adenosine monophosphate. von Herrath M, et al. Z Lebensm Unters Forsch, 1988 May. PMID 3291467

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
      Title: GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
    2. Hypothesized that decreased FBP1 mRNA level could be due to the effect of Maf1 on tgm silencing (tRNA gene mediated silencing).
      Title: Maf1, repressor of tRNA transcription, is involved in the control of gluconeogenetic genes in Saccharomyces cerevisiae.
    3. Cdc48(Ufd1-Npl4) complex and the ubiquitin receptors Dsk2 and Rad23 act between between polyubiquitination of FBPase and its degradation by the proteasome.
      Title: The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase.
    4. fructose-1,6-bisphosphatase and malate dehydrogenase degradation is mediated by distinct proteolytic pathways and signaling events
      Title: Degradation of the gluconeogenic enzymes fructose-1,6-bisphosphatase and malate dehydrogenase is mediated by distinct proteolytic pathways and signaling events.
    5. Influences the connection between DNA damage, aging and oxidative stress through either direct signalling or an intricate adaptation in energy metabolism.
      Title: Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose 1,6-bisphosphate 1-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose 1,6-bisphosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose 1,6-bisphosphate 1-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fructose 1,6-bisphosphate 1-phosphatase
    NP_013481.3
    • Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      873746..874792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182266.3 → NP_013481.3  TPA: fructose 1,6-bisphosphate 1-phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013481.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ13, P09201
      UniProtKB/TrEMBL
      A7A1Q3, B5VNR4, C7GRW9, C8ZDY7, G2WJJ3, N1P043
      Conserved Domains (1) summary
      COG0158
      Location:20 → 348
      Fbp; Fructose-1,6-bisphosphatase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09201.2

    Gene LinkOut

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