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    DLD2 D-lactate dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851376, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DLD2
    Official Full Name
    D-lactate dehydrogenase
    Primary source
    SGD:S000002337
    Locus tag
    YDL178W
    See related
    AllianceGenome:SGD:S000002337; FungiDB:YDL178W; VEuPathDB:YDL178W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AIP2
    Summary
    Enables several functions, including (R)-2-hydroxyglutarate dehydrogenase activity; D-lactate dehydrogenase (cytochrome) activity; and FAD binding activity. Involved in lactate catabolic process. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 1. Orthologous to human D2HGDH (D-2-hydroxyglutarate dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See DLD2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (139522..141114)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Ait1p Neighboring gene Pcl9p Neighboring gene uncharacterized protein Neighboring gene Gid12p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Closing the gap: yeast electron-transferring flavoprotein links the oxidation of d-lactate and d-α-hydroxyglutarate to energy production via the respiratory chain. Toplak M, et al. FEBS J, 2019 Sep. PMID 31081204, Free PMC Article
    2. Kinetic activation of yeast mitochondrial D-lactate dehydrogenase by carboxylic acids. Mourier A, et al. Biochim Biophys Acta, 2008 Oct. PMID 18640090
    3. Oligomeric Aip2p/Dld2p modifies the protein conformation of both properly folded and misfolded substrates in vitro. Hachiya NS, et al. Biochem Biophys Res Commun, 2004 Oct 8. PMID 15351742
    4. Oligomeric Aip2p/Dld2p forms a novel grapple-like structure and has an ATP-dependent F-actin conformation modifying activity in vitro. Hachiya NS, et al. Biochem Biophys Res Commun, 2004 Aug 6. PMID 15249227
    5. Interaction of D-lactate dehydrogenase protein 2 (Dld2p) with F-actin: implication for an alternative function of Dld2p. Hachiya NS, et al. Biochem Biophys Res Commun, 2004 Jun 18. PMID 15158445

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we conclude that the formation of a product-reduced Dld2 complex suppresses electron transfer to dioxygen but favors the rapid reduction in yETF, thus preventing the loss of electrons and the generation of reactive oxygen species.
      Title: Closing the gap: yeast electron-transferring flavoprotein links the oxidation of d-lactate and d-α-hydroxyglutarate to energy production via the respiratory chain.
    2. Dld2 and Dld3, both currently annotated as D-lactate dehydrogenases, efficiently oxidized d-2-hydroxyglutarate to alpha-ketoglutarate.
      Title: Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables (R)-2-hydroxyglutarate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-lactate dehydrogenase (cytochrome) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-lactate dehydrogenase (cytochrome) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lactate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-lactate dehydrogenase
    NP_010103.1
    • D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in lactate catabolism; located in the mitochondrial matrix

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      139522..141114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180238.1 → NP_010103.1  TPA: D-lactate dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010103.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRH4, P46681, Q66RH8
      UniProtKB/TrEMBL
      A6ZXF3, B3LH62, B5VF94, C7GL24, C8Z6C6, G2WBY7, N1PAJ9
      Conserved Domains (1) summary
      COG0277
      Location:68 → 530
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46681.1

    Gene LinkOut

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