IMA1 oligo-1,6-glucosidase IMA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: IMA1
Official Full Name: oligo-1,6-glucosidase IMA1
Primary source: SGD:S000003519
Locus tag: YGR287C
See related: AllianceGenome:SGD:S000003519; FungiDB:YGR287C; VEuPathDB:YGR287C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables oligo-1,6-glucosidase activity and sucrose alpha-glucosidase activity. Involved in disaccharide catabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Results show that 2 amino acid residues appeared important in determining the substrate specificity of alpha-glucosidases.
Title: Steric hindrance by 2 amino acid residues determines the substrate specificity of isomaltase from Saccharomyces cerevisiae.
Discovery of a novel family of alpha-glucosidase IMA genes.
Title: Discovery of a novel family of alpha-glucosidase IMA genes in yeast Saccharomyces cerevisiae.
features of the isomaltase active site pocket prevent isomalto-oligosaccharides from binding to the active site effectively.
Title: Crystal structures of isomaltase from Saccharomyces cerevisiae and in complex with its competitive inhibitor maltose.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables alpha-1,4-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-amylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables glucan 1,4-alpha-maltotriohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables oligo-1,6-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oligo-1,6-glucosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables oligo-1,6-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables sucrose alpha-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sucrose alpha-glucosidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in disaccharide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in disaccharide catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in disaccharide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maltose catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in maltose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sucrose catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_011803.3

Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; member of the IMA isomaltase family

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The following sections contain reference sequences that belong to a specific genome build. Explain