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    MAL12 alpha-glucosidase MAL12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853209, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MAL12
    Official Full Name
    alpha-glucosidase MAL12
    Primary source
    SGD:S000003524
    Locus tag
    YGR292W
    See related
    AllianceGenome:SGD:S000003524; FungiDB:YGR292W; VEuPathDB:YGR292W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha-1,4-glucosidase activity and glucan 1,4-alpha-maltotriohydrolase activity. Involved in maltose catabolic process and sucrose catabolic process. Located in plasma membrane. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MAL12 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1076599..1078353)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene transcription factor MAL13 Neighboring gene alpha-glucoside permease Neighboring gene seripauperin PAU12 Neighboring gene Cos6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene dosage effects on the synthesis of maltase in yeast. Mowshowitz DB. J Bacteriol, 1979 Mar. PMID 374342, Free PMC Article
    2. Alpha-glucosidase folding during urea denaturation: enzyme kinetics and computational prediction. Wu XQ, et al. Appl Biochem Biotechnol, 2010 Mar. PMID 19418260
    3. A novel competitive class of α-glucosidase inhibitors: (E)-1-phenyl-3-(4-styrylphenyl)urea derivatives. Kim JY, et al. Chembiochem, 2010 Oct 18. PMID 20827790
    4. Novel glycoside of vanillyl alcohol, 4-hydroxy-3-methoxybenzyl-α-D-glucopyranoside: study of enzymatic synthesis, in vitro digestion and antioxidant activity. Veličković D, et al. Bioprocess Biosyst Eng, 2012 Sep. PMID 22307809
    5. Comparison of the molecular interactions of 7'-carboxyalkyl apigenin derivatives with S. cerevisiae α-glucosidase. Qi YJ, et al. Comput Biol Chem, 2017 Apr. PMID 28131019

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural changes in alpha-glucosidase during urea denaturation, was investigated.
      Title: Alpha-glucosidase folding during urea denaturation: enzyme kinetics and computational prediction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,4-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,4-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-amylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucan 1,4-alpha-maltotriohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucan 1,4-alpha-maltotriohydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligo-1,6-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sucrose alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in disaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maltose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maltose catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maltose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sucrose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sucrose catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    alpha-glucosidase MAL12
    NP_011808.3
    • Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1076599..1078353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181421.3 → NP_011808.3  TPA: alpha-glucosidase MAL12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011808.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV67, P53341
      UniProtKB/TrEMBL
      A6ZUU5, C7GT48, E1AFY8, F8LG06, G2WF18
      Conserved Domains (2) summary
      cd11333
      Location:15 → 501
      AmyAc_SI_OligoGlu_DGase; Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins
      pfam16657
      Location:511 → 583
      Malt_amylase_C; Maltogenic Amylase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53341.1

    Gene LinkOut

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