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    JSN1 Jsn1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853553, updated on 28-Oct-2024

    Summary

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    Official Symbol
    JSN1
    Official Full Name
    Jsn1p
    Primary source
    SGD:S000003851
    Locus tag
    YJR091C
    See related
    AllianceGenome:SGD:S000003851; FungiDB:YJR091C; VEuPathDB:YJR091C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PUF1
    Summary
    Enables mRNA binding activity. Involved in establishment of mitochondrion localization; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and protein-containing complex localization. Located in cytoplasmic side of mitochondrial outer membrane and fungal-type cell wall. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See JSN1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (595061..598336, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene survivin Neighboring gene SCF ubiquitin ligase complex subunit GRR1 Neighboring gene Bud4p Neighboring gene cleavage polyadenylation factor subunit FIP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microtubule stability in budding yeast: characterization and dosage suppression of a benomyl-dependent tubulin mutant. Machin NA, et al. Mol Biol Cell, 1995 Sep. PMID 8534919, Free PMC Article
    2. A role for Jsn1p in recruiting the Arp2/3 complex to mitochondria in budding yeast. Fehrenbacher KL, et al. Mol Biol Cell, 2005 Nov. PMID 16107558, Free PMC Article
    3. Dosage suppressors of a benomyl-dependent tubulin mutant: evidence for a link between microtubule stability and cellular metabolism. Machin NA, et al. Genetics, 1996 Dec. PMID 8978026, Free PMC Article
    4. Phosphorylation of mRNA-Binding Proteins Puf1 and Puf2 by TORC2-Activated Protein Kinase Ypk1 Alleviates Their Repressive Effects. Galez HA, et al. Membranes (Basel), 2021 Jun 30. PMID 34209236, Free PMC Article
    5. PUF protein-mediated deadenylation is catalyzed by Ccr4p. Goldstrohm AC, et al. J Biol Chem, 2007 Jan 5. PMID 17090538

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. multiple Puf proteins coordinately regulate YHB1 mRNA to protect cells from nitric oxide stress.
      Title: Conditional regulation of Puf1p, Puf4p, and Puf5p activity alters YHB1 mRNA stability for a rapid response to toxic nitric oxide stress in yeast.
    2. These results identify the first mRNA targets of Puf1p-mediated decay.
      Title: Puf1p acts in combination with other yeast Puf proteins to control mRNA stability.
    3. Thus, Jsn1p has physical interactions with mitochondria-associated Arp2/3 complex and contributes to physical and functional association of the Arp2/3 complex with mitochondria.
      Title: A role for Jsn1p in recruiting the Arp2/3 complex to mitochondria in budding yeast.
    4. Ccr4p catalyzes PUF protein-mediated deadenylation using a Pop2p bridge to recruit a multifunctional Pop2p complex to the mRNA
      Title: PUF protein-mediated deadenylation is catalyzed by Ccr4p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR AU-rich region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in post-transcriptional regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of biological quality IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Jsn1p
    NP_012624.1
    • Member of the Puf family of RNA-binding proteins; interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl; JSN1 has a paralog, PUF2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      595061..598336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181748.1 → NP_012624.1  TPA: Jsn1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012624.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWQ9, P47135
      UniProtKB/TrEMBL
      A6ZQ46, C7GMB6, G2WH93
      Conserved Domains (1) summary
      COG5099
      Location:58 → 920
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47135.1

    Gene LinkOut

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