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    ELF1 Elf1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853697, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ELF1
    Official Full Name
    Elf1p
    Primary source
    SGD:S000001643
    Locus tag
    YKL160W
    See related
    AllianceGenome:SGD:S000001643; FungiDB:YKL160W; VEuPathDB:YKL160W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA polymerase II complex binding activity. Involved in transcription elongation by RNA polymerase II and transcription initiation-coupled chromatin remodeling. Located in nucleus. Part of transcription elongation factor complex. Orthologous to human ELOF1 (elongation factor 1). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See ELF1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (153269..153706)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene type II protein arginine methyltransferase Neighboring gene putative protein kinase KDX1 Neighboring gene Rcn1p Neighboring gene metallo-aminopeptidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uniform transitions of the general RNA polymerase II transcription complex. Mayer A, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20818391
    2. Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast. Gibney PA, et al. Mol Biol Cell, 2018 Apr 15. PMID 29444955, Free PMC Article
    3. Binding of eIF3 in complex with eIF5 and eIF1 to the 40S ribosomal subunit is accompanied by dramatic structural changes. Zeman J, et al. Nucleic Acids Res, 2019 Sep 5. PMID 31291455, Free PMC Article
    4. A Genetic Map of the Response to DNA Damage in Human Cells. Olivieri M, et al. Cell, 2020 Jul 23. PMID 32649862, Free PMC Article
    5. Opposite roles of transcription elongation factors Spt4/5 and Elf1 in RNA polymerase II transcription through B-form versus non-B DNA structures. Xu J, et al. Nucleic Acids Res, 2021 May 21. PMID 33877330, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
      Title: Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
    2. Opposite roles of transcription elongation factors Spt4/5 and Elf1 in RNA polymerase II transcription through B-form versus non-B DNA structures.
      Title: Opposite roles of transcription elongation factors Spt4/5 and Elf1 in RNA polymerase II transcription through B-form versus non-B DNA structures.
    3. Cryo-EM structures indicate eukaryotic initiation factor eIF3 as a molecular embracer of the 40S subunit, and the binding of eIF1 and eIF5 further fortified the compact architecture of eIF3.
      Title: Binding of eIF3 in complex with eIF5 and eIF1 to the 40S ribosomal subunit is accompanied by dramatic structural changes.
    4. Elf1 has a role in the regulation of transcription elongation
      Title: Identification and characterization of Elf1, a conserved transcription elongation factor in Saccharomyces cerevisiae.
    5. Report shows yeast transcription elongation factor Elf1 as a new substrate for both monomeric and tetrameric forms of protein kinase CK2.
      Title: Yeast elf1 factor is phosphorylated and interacts with protein kinase CK2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription elongation factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Elf1p
    NP_012762.1
    • Transcription elongation factor with a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      153269..153706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179726.1 → NP_012762.1  TPA: Elf1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012762.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX39, P36053
      UniProtKB/TrEMBL
      A6ZZG4, B3LQU5, C7GT76, C8ZC15, G2WHN1, N1NZN6
      Conserved Domains (1) summary
      COG4888
      Location:1 → 88
      Elf1; Transcription elongation factor Elf1, contains Zn-ribbon domain [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36053.1

    Gene LinkOut

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