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    RSN1 Rsn1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855308, updated on 17-May-2024

    Summary

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    Gene symbol
    RSN1
    Gene description
    Rsn1p
    Primary source
    FungiDB:YMR266W
    Locus tag
    YMR266W
    See related
    SGD:S000004879; AllianceGenome:SGD:S000004879; VEuPathDB:YMR266W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable calcium activated cation channel activity. Predicted to be involved in cation transmembrane transport. Located in membrane. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human TMEM63A (transmembrane protein 63A) and TMEM63B (transmembrane protein 63B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RSN1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (798518..801379)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Cue1p Neighboring gene uncharacterized protein Neighboring gene inorganic diphosphatase PPA2 Neighboring gene U6 snRNP complex subunit PRP24

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast tumor suppressor homologue Sro7p is required for targeting of the sodium pumping ATPase to the cell surface. Wadskog I, et al. Mol Biol Cell, 2006 Dec. PMID 17005914, Free PMC Article
    2. The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis. Friederichs JM, et al. PLoS Genet, 2011 Nov. PMID 22125491, Free PMC Article
    3. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347
    4. Diverse functions of spindle assembly checkpoint genes in Saccharomyces cerevisiae. Daniel JA, et al. Genetics, 2006 Jan. PMID 16157669, Free PMC Article
    5. Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. Logan MR, et al. BMC Genomics, 2008 Jul 15. PMID 18627629, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rsn1p
    NP_013993.1
    • Membrane hypothetical protein; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      798518..801379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182773.1 → NP_013993.1  TPA: Rsn1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W092, Q03516
      UniProtKB/TrEMBL
      A0A8H4BY46, B3LMF3, B5VQ30, C8ZFD2
      Conserved Domains (1) summary
      COG5594
      Location:21 → 914
      COG5594; Uncharacterized integral membrane protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03516.1

    Gene LinkOut

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