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    DBP1 putative DEAD-box ATP-dependent RNA helicase DBP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855984, updated on 14-Nov-2024

    Summary

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    Official Symbol
    DBP1
    Official Full Name
    putative DEAD-box ATP-dependent RNA helicase DBP1
    Primary source
    SGD:S000006040
    Locus tag
    YPL119C
    See related
    AllianceGenome:SGD:S000006040; FungiDB:YPL119C; VEuPathDB:YPL119C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LPH8
    Summary
    Enables ATP hydrolysis activity; DNA/RNA helicase activity; and single-stranded RNA binding activity. Involved in positive regulation of formation of translation preinitiation complex and translational initiation. Located in cytoplasm. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked) and DDX3Y (DEAD-box helicase 3 Y-linked). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See DBP1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (324411..326264, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene beclin 1 Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein MRP51 Neighboring gene isopentenyl-diphosphate delta-isomerase IDI1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A suppressor of yeast spp81/ded1 mutations encodes a very similar putative ATP-dependent RNA helicase. Jamieson DJ, et al. Mol Microbiol, 1991 Apr. PMID 1857205
    2. Dynamics and processivity of 40S ribosome scanning on mRNA in yeast. Berthelot K, et al. Mol Microbiol, 2004 Feb. PMID 14763975
    3. The molecular evolution of PL10 homologs. Chang TC, et al. BMC Evol Biol, 2010 May 3. PMID 20438638, Free PMC Article
    4. Functional interplay between DEAD-box RNA helicases Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in vivo. Sen ND, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31299079, Free PMC Article
    5. DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA. Gao J , et al. Chem Commun (Camb), 2019 Apr 11. PMID 30855040, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional interplay between Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in Saccharomyces cerevisiae has been reported.
      Title: Functional interplay between DEAD-box RNA helicases Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA/RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G-quadruplex DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of formation of translation preinitiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative DEAD-box ATP-dependent RNA helicase DBP1
    NP_015206.1
    • ATP-dependent RNA helicase of the DEAD-box protein family; accelerates eIF4F-dependent assembly of 48S translation preinitiation complex (PIC), stimulating recruitment of mRNAs with long, structured 5'-UTRs; cooperates with DEAD-box RNA helicase and paralog Ded1p, stimulating PIC attachment and highly processive scanning by the 40S ribosomal subunit; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      324411..326264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183933.1 → NP_015206.1  TPA: putative DEAD-box ATP-dependent RNA helicase DBP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3P9, P20446, P24784
      UniProtKB/TrEMBL
      B3LKV6, C7GJ72, C8ZIR1, N1NVG6
      Conserved Domains (1) summary
      COG0513
      Location:129 → 595
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24784.2

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