SPO13 Spo13p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SPO13
Official Full Name: Spo13p
Primary source: SGD:S000001056
Locus tag: YHR014W
See related: AllianceGenome:SGD:S000001056; FungiDB:YHR014W; VEuPathDB:YHR014W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in meiotic sister chromatid cohesion; positive regulation of sister chromatid cohesion; and protein localization to chromosome, centromeric region. Located in condensed chromosome, centromeric region; meiotic spindle; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SPO13 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (132047..132922)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spo13/MEIKIN ensures a Two-Division meiosis by preventing the activation of APC/C[Ama1] at meiosis I.
Title: Spo13/MEIKIN ensures a Two-Division meiosis by preventing the activation of APC/C(Ama1) at meiosis I.
The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast.
Title: The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast.
results outline complex interactions, in cis and in trans, between genes encoding PAF1 and ESCRT-II complex components that affect telomere function and cell viability in yeast
Title: An interplay between Shugoshin and Spo13 for centromeric cohesin protection and sister kinetochore mono-orientation during meiosis I in Saccharomyces cerevisiae.
Dbf4-dependent Cdc7 kinase (DDK) regulates monopolin localization together with the polo-kinase Cdc5 bound to Spo13, probably through phosphorylation of the monopolin subunit Lrs4
Title: Dbf4-dependent CDC7 kinase links DNA replication to the segregation of homologous chromosomes in meiosis I.
Spo13 destruction in anaphase I is not essential for meiosis.
Title: A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I.
Spo13 is required to prevent sister kinetochore biorientation by facilitating the recruitment of the monopolin complex to kinetochores during meiosis 1.
Title: Spo13 facilitates monopolin recruitment to kinetochores and regulates maintenance of centromeric cohesion during yeast meiosis.
Spo13 has the ability to regulate both the stepwise loss of sister chromatid cohesion and kinetochore coorientation, two essential features of chromosome segregation during meiosis 1.
Title: Spo13 maintains centromeric cohesion and kinetochore coorientation during meiosis I.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to chromosome, centromeric region	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sporulation resulting in formation of a cellular spore	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Spo13p

NP_011878.1

Meiotic regulator; involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II; promotes phosphorylation of Cdc5p substrates in MI and impacts Hrr25p function in MII; substrate of the anaphase-promoting complex (APC) that is degraded during anaphase I; expressed solely in meiotic cells