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    myoI class VII unconventional myosin [ Dictyostelium discoideum AX4 ]

    Gene ID: 8619600, updated on 18-Sep-2024

    Summary

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    Official Symbol
    myoI
    Official Full Name
    class VII unconventional myosin
    Primary source
    dictyBase:DDB_G0274455
    Locus tag
    DDB_G0274455
    See related
    AmoebaDB:DDB_G0274455; VEuPathDB:DDB_G0274455
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Dictyostelium discoideum AX4 (strain: AX4)
    Lineage
    Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
    Old locus tag
    DDBDRAFT_0185049; DDBDRAFT_0217552; DDB_0185049; DDB_0217552
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_007088.5 (4534415..4541848)

    Chromosome 2 - NC_007088.5Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_007088.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. VASP-mediated actin dynamics activate and recruit a filopodia myosin. Arthur AL, et al. Elife, 2021 May 27. PMID 34042588, Free PMC Article
    2. MyTH4-FERM myosins have an ancient and conserved role in filopod formation. Petersen KJ, et al. Proc Natl Acad Sci U S A, 2016 Dec 13. PMID 27911821, Free PMC Article
    3. Characterization of a myosin VII MyTH/FERM domain. Moen RJ, et al. J Mol Biol, 2011 Oct 14. PMID 21875595, Free PMC Article
    4. The SH3 domain of a M7 interacts with its C-terminal proline-rich region. Wang Q, et al. Protein Sci, 2007 Feb. PMID 17189480, Free PMC Article
    5. Transcriptional transitions during Dictyostelium spore germination. Xu Q, et al. Eukaryot Cell, 2004 Oct. PMID 15470238, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by dictyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular component assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spore germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in filopodium tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in phagocytic cup IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane bounded cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    class VII unconventional myosin
    Names
    myosin VII

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_007088.5 Reference assembly

      Range
      4534415..4541848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_639079.1 → XP_644171.1  class VII unconventional myosin [Dictyostelium discoideum AX4]

      See identical proteins and their annotated locations for XP_644171.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P90536, Q555A2, Q869S1, Q9U1M8
      Conserved Domains (8) summary
      smart00139
      Location:1155 → 1313
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:12 → 679
      MYSc; Myosin. Large ATPases
      smart00295
      Location:2061 → 2275
      B41; Band 4.1 homologues
      cd14473
      Location:1430 → 1522
      FERM_B-lobe; FERM domain B-lobe
      cd14883
      Location:27 → 676
      MYSc_Myo22; class XXII myosin, motor domain
      pfam07653
      Location:1622 → 1676
      SH3_2; Variant SH3 domain
      cl09511
      Location:2165 → 2275
      FERM_B-lobe; FERM domain B-lobe
      cl17171
      Location:2271 → 2341
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials