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    SLC28A1 solute carrier family 28 member 1 [ Homo sapiens (human) ]

    Gene ID: 9154, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SLC28A1provided by HGNC
    Official Full Name
    solute carrier family 28 member 1provided by HGNC
    Primary source
    HGNC:HGNC:11001
    See related
    Ensembl:ENSG00000156222 MIM:606207; AllianceGenome:HGNC:11001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CNT1; HCNT1; URCTU
    Summary
    Enables azole transmembrane transporter activity; pyrimidine- and adenosine-specific:sodium symporter activity; and uridine transmembrane transporter activity. Involved in azole transmembrane transport and nucleoside transport. Located in apical plasma membrane; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney (RPKM 9.5), small intestine (RPKM 9.4) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC28A1 in Genome Data Viewer
    Location:
    15q25.3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (84884662..84975649)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (82637040..82727893)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (85427893..85518880)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85291347-85292186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9992 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41887 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85303845-85304346 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85309319-85309820 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85309821-85310320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9993 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85325731-85326318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85326319-85326906 Neighboring gene zinc finger protein 592 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41909 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85346873-85347374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85347375-85347874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85359685-85360215 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85362343-85362874 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85362875-85363404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85370192-85370692 Neighboring gene skeletal muscle cis-regulatory module overlapping ALPK3 Neighboring gene uncharacterized LOC124900361 Neighboring gene alpha kinase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85405349-85405850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85406419-85406920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85406921-85407420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85426972-85427472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85427473-85427973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85432908-85433476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85467385-85467885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9995 Neighboring gene RNA, U6 small nuclear 339, pseudogene Neighboring gene RNA, U6 small nuclear 796, pseudogene Neighboring gene high mobility group box 1 pseudogene 43 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41947 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85522585-85523086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85523087-85523586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6775 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85524736-85525268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9997 Neighboring gene Sharpr-MPRA regulatory region 10787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6777 Neighboring gene phosphodiesterase 8A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10001 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41972 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_42025 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:85668261-85668811 Neighboring gene uncharacterized LOC124903545 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_42032 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:85708039-85708575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6778 Neighboring gene NIFK pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation. Rius M, et al. Mol Cancer Ther, 2009 Jan. PMID 19139132
    2. Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1). Ritzel MW, et al. Am J Physiol, 1997 Feb. PMID 9124315
    3. Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug. Mata JF, et al. Mol Pharmacol, 2001 Jun. PMID 11353816
    4. Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). Ritzel MW, et al. Mol Membr Biol, 2001 Jan-Mar. PMID 11396613
    5. Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity. García-Manteiga J, et al. Clin Cancer Res, 2003 Oct 15. PMID 14581375

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of deoxyribonucleoside transport mediated by concentrative nucleoside transporters.
      Title: Characterization of deoxyribonucleoside transport mediated by concentrative nucleoside transporters.
    2. Expression of the nucleoside transporters hENT1 (SLC29) and hCNT1 (SLC28) in pediatric acute myeloid leukemia.
      Title: Expression of the nucleoside transporters hENT1 (SLC29) and hCNT1 (SLC28) in pediatric acute myeloid leukemia.
    3. Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) in the Asian comparison.
      Title: Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions.
    4. results that validate the newly developed structural homology model of CNT membrane architecture for human CNTs, revealed extended conformationally mobile regions within transport-domain TMs, identified pore-lining residues of functional importance, and provided evidence of an emerging novel elevator-type mechanism of transporter function.
      Title: Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance.
    5. ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2.
      Title: The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2.
    6. hCNT1 is a putative determinant for nucleoside analog chemoresistance in ovarian cancer.
      Title: Defective hCNT1 transport contributes to gemcitabine chemoresistance in ovarian cancer subtypes: overcoming transport defects using a nanoparticle approach.
    7. Human CNT1 fits the profile of a transceptor in a substrate translocation-independent manner and is likely to be relevant to tumor biology.
      Title: Concentrative nucleoside transporter 1 (hCNT1) promotes phenotypic changes relevant to tumor biology in a translocation-independent manner.
    8. MUC4 and hCNT1 as potential targets to ameliorate the response of pancreatic tumors to gemcitabine treatment.
      Title: The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family.
    9. CNT1-mediated gemcitabine uptake shows a higher correlation with the CNT1 expression level than does ENT1-mediated uptake with ENT1 expression.
      Title: Variability of gemcitabine accumulation and its relationship to expression of nucleoside transporters in peripheral blood mononuclear cells.
    10. Site-directed mutagenesis analysis reveals that only one sodium binding site is affected by a mutation; lack of serine546 residue is responsible for apparent loss of CNT1 function.
      Title: Functional analysis of the human concentrative nucleoside transporter-1 variant hCNT1S546P provides insight into the sodium-binding pocket.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Uridine-cytidineuria
    MedGen: C4760647 OMIM: 618477 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of age-at-onset in Alzheimer's disease.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables azole transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytidine transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleoside:sodium symporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables purine nucleobase transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables pyrimidine- and adenosine-specific:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrimidine- and adenosine-specific:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in azole transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytidine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytidine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytidine transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nucleoside import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleoside transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleobase transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in pyrimidine nucleobase transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine-containing compound transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uridine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in uridine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in brush border membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    sodium/nucleoside cotransporter 1
    Names
    Na(+)/nucleoside cotransporter 1
    concentrative nucleoside transporter 1
    sodium-coupled nucleoside transporter 1
    solute carrier family 28 (concentrative nucleoside transporter), member 1
    solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287761.2 → NP_001274690.1  sodium/nucleoside cotransporter 1 isoform 3

      See identical proteins and their annotated locations for NP_001274690.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' UTR and lacks three in-frame exons in the 3' coding region, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AC087468, AK296075
      Consensus CDS
      CCDS73777.1
      UniProtKB/TrEMBL
      B7Z3L6
      Related
      ENSP00000443752.1, ENST00000538177.5
      Conserved Domains (4) summary
      TIGR00804
      Location:179 → 424
      nupC; nucleoside transporter
      pfam01773
      Location:184 → 253
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:347 → 424
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:265 → 361
      Gate; Nucleoside recognition

    2. NM_001287762.2 → NP_001274691.1  sodium/nucleoside cotransporter 1 isoform 1

      See identical proteins and their annotated locations for NP_001274691.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 4 encode the same protein.
      Source sequence(s)
      AC087468, AK296075, U62968
      Consensus CDS
      CCDS10334.1
      UniProtKB/Swiss-Prot
      A0AV42, A8K7I2, O00335, O00336, O00337, Q5U5S6, Q5U648, Q9UEZ9
      UniProtKB/TrEMBL
      Q96PL7
      Related
      ENSP00000286749.3, ENST00000286749.3
      Conserved Domains (4) summary
      TIGR00804
      Location:179 → 590
      nupC; nucleoside transporter
      pfam01773
      Location:184 → 253
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:367 → 590
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:265 → 361
      Gate; Nucleoside recognition

    3. NM_001321721.2 → NP_001308650.1  sodium/nucleoside cotransporter 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087468, AK296074, AK298369
      UniProtKB/TrEMBL
      B7Z3L5, B7Z533
      Conserved Domains (4) summary
      TIGR00804
      Location:179 → 512
      nupC; nucleoside transporter
      pfam01773
      Location:184 → 253
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:367 → 535
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:265 → 361
      Gate; Nucleoside recognition

    4. NM_001321722.2 → NP_001308651.1  sodium/nucleoside cotransporter 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC087468, AK296074, AK298369
      UniProtKB/TrEMBL
      B7Z3L5
      Conserved Domains (4) summary
      TIGR00804
      Location:179 → 590
      nupC; nucleoside transporter
      pfam01773
      Location:184 → 253
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:367 → 590
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:265 → 361
      Gate; Nucleoside recognition

    5. NM_004213.5 → NP_004204.3  sodium/nucleoside cotransporter 1 isoform 1

      See identical proteins and their annotated locations for NP_004204.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 encode the same protein.
      Source sequence(s)
      AC087468, AK296074, U62968
      Consensus CDS
      CCDS10334.1
      UniProtKB/Swiss-Prot
      A0AV42, A8K7I2, O00335, O00336, O00337, Q5U5S6, Q5U648, Q9UEZ9
      UniProtKB/TrEMBL
      Q96PL7
      Related
      ENSP00000378074.1, ENST00000394573.6
      Conserved Domains (4) summary
      TIGR00804
      Location:179 → 590
      nupC; nucleoside transporter
      pfam01773
      Location:184 → 253
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:367 → 590
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:265 → 361
      Gate; Nucleoside recognition

    6. NM_201651.3 → NP_964014.1  sodium/nucleoside cotransporter 1 isoform 2

      See identical proteins and their annotated locations for NP_964014.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK296075, BC029788, BI765705
      Consensus CDS
      CCDS10335.1
      UniProtKB/Swiss-Prot
      O00337
      UniProtKB/TrEMBL
      B7Z3L6
      Related
      ENSP00000341629.2, ENST00000338602.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      84884662..84975649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522204.4 → XP_011520506.1  sodium/nucleoside cotransporter 1 isoform X1

      See identical proteins and their annotated locations for XP_011520506.1

      UniProtKB/TrEMBL
      B7Z3L5
      Conserved Domains (1) summary
      TIGR00804
      Location:179 → 590
      nupC; nucleoside transporter

    2. XM_011522203.3 → XP_011520505.1  sodium/nucleoside cotransporter 1 isoform X1

      See identical proteins and their annotated locations for XP_011520505.1

      UniProtKB/TrEMBL
      B7Z3L5
      Conserved Domains (1) summary
      TIGR00804
      Location:179 → 590
      nupC; nucleoside transporter

    3. XM_011522215.3 → XP_011520517.1  sodium/nucleoside cotransporter 1 isoform X8

      Conserved Domains (4) summary
      TIGR00804
      Location:179 → 424
      nupC; nucleoside transporter
      pfam01773
      Location:184 → 253
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:347 → 424
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:265 → 361
      Gate; Nucleoside recognition

    4. XM_011522209.3 → XP_011520511.1  sodium/nucleoside cotransporter 1 isoform X3

      UniProtKB/TrEMBL
      B7Z3L5
      Conserved Domains (1) summary
      TIGR00804
      Location:179 → 564
      nupC; nucleoside transporter

    5. XM_011522205.4 → XP_011520507.1  sodium/nucleoside cotransporter 1 isoform X1

      See identical proteins and their annotated locations for XP_011520507.1

      UniProtKB/TrEMBL
      B7Z3L5
      Conserved Domains (1) summary
      TIGR00804
      Location:179 → 590
      nupC; nucleoside transporter

    6. XM_011522206.4 → XP_011520508.1  sodium/nucleoside cotransporter 1 isoform X1

      See identical proteins and their annotated locations for XP_011520508.1

      UniProtKB/TrEMBL
      B7Z3L5
      Conserved Domains (1) summary
      TIGR00804
      Location:179 → 590
      nupC; nucleoside transporter

    7. XM_011522208.4 → XP_011520510.1  sodium/nucleoside cotransporter 1 isoform X2

      UniProtKB/TrEMBL
      B7Z3L5
      Conserved Domains (4) summary
      TIGR00804
      Location:170 → 581
      nupC; nucleoside transporter
      pfam01773
      Location:175 → 244
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:358 → 581
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:256 → 352
      Gate; Nucleoside recognition

    8. XM_017022723.2 → XP_016878212.1  sodium/nucleoside cotransporter 1 isoform X5

      UniProtKB/TrEMBL
      B7Z3L5

    9. XM_011522212.2 → XP_011520514.1  sodium/nucleoside cotransporter 1 isoform X6

      UniProtKB/TrEMBL
      B7Z3L5
      Conserved Domains (4) summary
      TIGR00804
      Location:179 → 512
      nupC; nucleoside transporter
      pfam01773
      Location:184 → 253
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:367 → 509
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:265 → 361
      Gate; Nucleoside recognition

    10. XM_011522210.3 → XP_011520512.1  sodium/nucleoside cotransporter 1 isoform X4

      UniProtKB/TrEMBL
      B7Z3L5
      Conserved Domains (4) summary
      TIGR00804
      Location:179 → 590
      nupC; nucleoside transporter
      pfam01773
      Location:184 → 253
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:367 → 590
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:265 → 361
      Gate; Nucleoside recognition

    11. XM_011522217.2 → XP_011520519.1  sodium/nucleoside cotransporter 1 isoform X9

      See identical proteins and their annotated locations for XP_011520519.1

      UniProtKB/TrEMBL
      B7Z3L6
      Conserved Domains (4) summary
      TIGR00804
      Location:179 → 424
      nupC; nucleoside transporter
      pfam01773
      Location:184 → 253
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:347 → 424
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:265 → 361
      Gate; Nucleoside recognition

    12. XM_011522214.3 → XP_011520516.1  sodium/nucleoside cotransporter 1 isoform X7

      UniProtKB/TrEMBL
      B7Z3L5
      Conserved Domains (4) summary
      TIGR00804
      Location:179 → 512
      nupC; nucleoside transporter
      pfam01773
      Location:184 → 253
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:367 → 509
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:265 → 361
      Gate; Nucleoside recognition

    13. XM_047433322.1 → XP_047289278.1  sodium/nucleoside cotransporter 1 isoform X11

    14. XM_011522218.3 → XP_011520520.1  sodium/nucleoside cotransporter 1 isoform X12

      Conserved Domains (2) summary
      pfam01773
      Location:184 → 253
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07670
      Location:265 → 361
      Gate; Nucleoside recognition

    15. XM_047433320.1 → XP_047289276.1  sodium/nucleoside cotransporter 1 isoform X1

    16. XM_011522216.2 → XP_011520518.1  sodium/nucleoside cotransporter 1 isoform X10

      See identical proteins and their annotated locations for XP_011520518.1

      UniProtKB/TrEMBL
      B7Z3L5
      Conserved Domains (4) summary
      TIGR00804
      Location:101 → 512
      nupC; nucleoside transporter
      pfam01773
      Location:106 → 175
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:289 → 512
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:187 → 283
      Gate; Nucleoside recognition

    RNA

    1. XR_931945.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      82637040..82727893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379175.1 → XP_054235150.1  sodium/nucleoside cotransporter 1 isoform X1

    2. XM_054379174.1 → XP_054235149.1  sodium/nucleoside cotransporter 1 isoform X1

    3. XM_054379185.1 → XP_054235160.1  sodium/nucleoside cotransporter 1 isoform X8

    4. XM_054379180.1 → XP_054235155.1  sodium/nucleoside cotransporter 1 isoform X3

    5. XM_054379176.1 → XP_054235151.1  sodium/nucleoside cotransporter 1 isoform X1

    6. XM_054379177.1 → XP_054235152.1  sodium/nucleoside cotransporter 1 isoform X1

    7. XM_054379179.1 → XP_054235154.1  sodium/nucleoside cotransporter 1 isoform X2

    8. XM_054379182.1 → XP_054235157.1  sodium/nucleoside cotransporter 1 isoform X5

    9. XM_054379183.1 → XP_054235158.1  sodium/nucleoside cotransporter 1 isoform X6

    10. XM_054379181.1 → XP_054235156.1  sodium/nucleoside cotransporter 1 isoform X4

    11. XM_054379186.1 → XP_054235161.1  sodium/nucleoside cotransporter 1 isoform X9

      UniProtKB/TrEMBL
      B7Z3L6

    12. XM_054379184.1 → XP_054235159.1  sodium/nucleoside cotransporter 1 isoform X7

    13. XM_054379188.1 → XP_054235163.1  sodium/nucleoside cotransporter 1 isoform X11

    14. XM_054379189.1 → XP_054235164.1  sodium/nucleoside cotransporter 1 isoform X12

    15. XM_054379178.1 → XP_054235153.1  sodium/nucleoside cotransporter 1 isoform X1

    16. XM_054379187.1 → XP_054235162.1  sodium/nucleoside cotransporter 1 isoform X10

    RNA

    1. XR_008489030.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00337.2 GenPept UniProtKB/Swiss-Prot:O00337

    Gene LinkOut

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