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    Cabin1 calcineurin binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94165, updated on 2-Nov-2024

    Summary

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    Symbol
    Cabin1provided by RGD
    Full Name
    calcineurin binding protein 1provided by RGD
    Primary source
    RGD:620263
    See related
    EnsemblRapid:ENSRNOG00000001237 AllianceGenome:RGD:620263
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cain
    Summary
    Enables protein domain specific binding activity and protein phosphatase 2B binding activity. Involved in negative regulation of apoptotic process and response to activity. Predicted to be located in aggresome; cytosol; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CABIN1 (calcineurin binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 62.0), Lung (RPKM 59.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cabin1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12892750..13014801)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12893314..13015357)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13836032..13963003)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483890 Neighboring gene glutathione S-transferase, theta 3 Neighboring gene D-dopachrome tautomerase Neighboring gene uncharacterized LOC102556116 Neighboring gene sushi domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene gamma-glutamyltransferase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Knocking down Cabin1 induces glomerular podocyte injury. Wen Y, et al. Int Urol Nephrol, 2018 May. PMID 29368245
    2. Upregulation of Cabin1 During Injury to Renal Tubular Epithelial Cells in Rats. Wen Y, et al. Iran J Kidney Dis, 2017 Nov. PMID 29190603
    3. Gene expression profiling of exercise-induced cardiac hypertrophy in rats. Iemitsu M, et al. Acta Physiol Scand, 2005 Dec. PMID 16266368
    4. Cain, a novel physiologic protein inhibitor of calcineurin. Lai MM, et al. J Biol Chem, 1998 Jul 17. PMID 9660798
    5. Effect of the knockdown of Cabin1 on p53 in glomerular podocyte. Wen Y, et al. J Recept Signal Transduct Res, 2016. PMID 26400065

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cabin1 involves in renal tubular epithelial cells mitochondrial dysfunction through SIRT1/p53 pathway.
      Title: Cabin1 involves in renal tubular epithelial cells mitochondrial dysfunction through SIRT1/p53 pathway.
    2. Knocking down Cabin1 induces the disruption of cytoskeleton and mitochondrial dysfunction in podocyte. Cabin1 could be a crucial factor in podocyte damage.
      Title: Knocking down Cabin1 induces glomerular podocyte injury.
    3. Injury to renal tubular epithelial cells results in up-regulation of cabin1 expression.
      Title: Upregulation of Cabin1 During Injury to Renal Tubular Epithelial Cells in Rats.
    4. In conclusion, Cabin1 expression significantly increases during podocyte injury. Knockdown of Cabin1 induces p53 expression decrease in cultured podocyte. Cabin1 may provide a new target to investigate podocyte injury.
      Title: Effect of the knockdown of Cabin1 on p53 in glomerular podocyte.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein phosphatase 2B binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcineurin-binding protein cabin-1
    Names
    calcineurin inhibitor
    calcineurin-binding protein cabin-1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053575.2 → NP_446027.2  calcineurin-binding protein cabin-1

      See identical proteins and their annotated locations for NP_446027.2

      Status: VALIDATED

      Source sequence(s)
      AF061947, DV716961, JAXUCZ010000020
      UniProtKB/Swiss-Prot
      O88480
      UniProtKB/TrEMBL
      A0A1W2Q6J1, A6JKH7
      Related
      ENSRNOP00000076295.1, ENSRNOT00000093157.3
      Conserved Domains (4) summary
      PHA03247
      Location:1914 → 2156
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:34 → 210
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2118 → 2152
      MEF2_binding; MEF2 binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      12892750..13014801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099132.2 → XP_038955060.1  calcineurin-binding protein cabin-1 isoform X3

      Conserved Domains (2) summary
      COG0457
      Location:34 → 210
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]

    2. XM_063279580.1 → XP_063135650.1  calcineurin-binding protein cabin-1 isoform X2

    3. XM_039099130.2 → XP_038955058.1  calcineurin-binding protein cabin-1 isoform X1

      UniProtKB/Swiss-Prot
      O88480
      Conserved Domains (4) summary
      PHA03247
      Location:1885 → 2127
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:34 → 210
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2089 → 2123
      MEF2_binding; MEF2 binding

    RNA

    1. XR_005497345.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88480.1 GenPept UniProtKB/Swiss-Prot:O88480

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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