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    SPEG striated muscle enriched protein kinase [ Homo sapiens (human) ]

    Gene ID: 10290, updated on 2-May-2024

    Summary

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    Official Symbol
    SPEGprovided by HGNC
    Official Full Name
    striated muscle enriched protein kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:16901
    See related
    Ensembl:ENSG00000072195 MIM:615950; AllianceGenome:HGNC:16901
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BPEG; CNM5; APEG1; MYLK6; APEG-1; SPEGbeta; SPEGalpha
    Summary
    This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Along with the desmin gene, expression of this gene may be controlled by the desmin locus control region. Mutations in this gene are associated with centronuclear myopathy 5. [provided by RefSeq, Jun 2016]
    Expression
    Broad expression in endometrium (RPKM 4.8), prostate (RPKM 4.5) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2q35
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219434843..219493629)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219919623..219978369)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220299565..220358351)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene aspartyl aminopeptidase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12356 Neighboring gene DNPEP antisense RNA 1 Neighboring gene desmin locus control region Neighboring gene VISTA enhancer hs2169 Neighboring gene desmin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220313846-220314453 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220315912-220316716 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:220317062-220318261 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:220325404-220325584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220329861-220330528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220330529-220331194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220331442-220331984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220339972-220340679 Neighboring gene Sharpr-MPRA regulatory region 8597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220341387-220342094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220348981-220349782 Neighboring gene ASIC4 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 15624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220361035-220361852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220361853-220362670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220362671-220363488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17153 Neighboring gene SPEG neighbor Neighboring gene GDP-mannose pyrophosphorylase A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A Novel SPEG mutation causing congenital myopathy with fiber size disproportion and dilated cardiomyopathy with heart transplantation. Gurgel-Giannetti J, et al. Neuromuscul Disord, 2021 Nov. PMID 34742623
    2. Homozygous SPEG Mutation Is Associated With Isolated Dilated Cardiomyopathy. Almannai M, et al. Circ Genom Precis Med, 2021 Apr. PMID 33794647, Free PMC Article
    3. A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy. Levitas A, et al. PLoS Genet, 2020 Sep. PMID 32925938, Free PMC Article
    4. Novel SPEG variant cause centronuclear myopathy in China. Tang J, et al. J Clin Lab Anal, 2020 Feb. PMID 31625632, Free PMC Article
    5. Novel SPEG mutations in congenital myopathies: Genotype-phenotype correlations. Qualls AE, et al. Muscle Nerve, 2019 Mar. PMID 30412272, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Novel SPEG mutation causing congenital myopathy with fiber size disproportion and dilated cardiomyopathy with heart transplantation.
      Title: A Novel SPEG mutation causing congenital myopathy with fiber size disproportion and dilated cardiomyopathy with heart transplantation.
    2. Homozygous SPEG Mutation Is Associated With Isolated Dilated Cardiomyopathy.
      Title: Homozygous SPEG Mutation Is Associated With Isolated Dilated Cardiomyopathy.
    3. Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation.
      Title: Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation.
    4. Novel SPEG variant cause centronuclear myopathy in China.
      Title: Novel SPEG variant cause centronuclear myopathy in China.
    5. A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy.
      Title: A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy.
    6. Striated muscle-specific serine/threonine-protein kinase beta segregates with high versus low responsiveness to endurance exercise training.
      Title: Striated muscle-specific serine/threonine-protein kinase beta segregates with high versus low responsiveness to endurance exercise training.
    7. Clinicians should consider evaluating a centronuclear myopathies patient for SPEG mutations even in the absence of centronuclear myopathies features
      Title: Novel SPEG mutations in congenital myopathies: Genotype-phenotype correlations.
    8. SPEG is present in cardiac muscle, where it plays a critical role; therefore, individuals with SPEG mutations additionally present with dilated cardiomyopathy.
      Title: SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Myopathy, centronuclear, 5
    MedGen: C4014814 OMIM: 615959 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1297, MGC12676

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle organ development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    striated muscle preferentially expressed protein kinase
    Names
    SPEG complex locus
    aortic preferentially expressed gene 1
    aortic preferentially expressed protein 1
    nuclear protein, marker for differentiated aortic smooth muscle and down-regulated with vascular injury
    NP_001166947.1
    NP_005867.3
    XP_005246294.1
    XP_005246296.1
    XP_005246297.1
    XP_005246298.1
    XP_005246299.1
    XP_006712252.1
    XP_006712256.1
    XP_011508781.1
    XP_016858648.2
    XP_016858650.2
    XP_016858651.2
    XP_024308294.2
    XP_047298847.1
    XP_047298848.1
    XP_047298849.1
    XP_047298850.1
    XP_047298851.1
    XP_047298852.1
    XP_047298853.1
    XP_047298854.1
    XP_047298856.1
    XP_047298857.1
    XP_047298858.1
    XP_047298859.1
    XP_047298860.1
    XP_047298861.1
    XP_047298862.1
    XP_047298863.1
    XP_047298864.1
    XP_047298865.1
    XP_047298866.1
    XP_047298867.1
    XP_047298868.1
    XP_047298870.1
    XP_047298873.1
    XP_047298874.1
    XP_047298875.1
    XP_047298876.1
    XP_047298877.1
    XP_047298878.1
    XP_047298879.1
    XP_054196108.1
    XP_054196109.1
    XP_054196110.1
    XP_054196111.1
    XP_054196112.1
    XP_054196113.1
    XP_054196114.1
    XP_054196115.1
    XP_054196116.1
    XP_054196117.1
    XP_054196118.1
    XP_054196119.1
    XP_054196120.1
    XP_054196121.1
    XP_054196122.1
    XP_054196123.1
    XP_054196124.1
    XP_054196125.1
    XP_054196126.1
    XP_054196127.1
    XP_054196128.1
    XP_054196129.1
    XP_054196130.1
    XP_054196131.1
    XP_054196132.1
    XP_054196133.1
    XP_054196134.1
    XP_054196135.1
    XP_054196136.1
    XP_054196137.1
    XP_054196138.1
    XP_054196139.1
    XP_054196140.1
    XP_054196141.1
    XP_054196142.1
    XP_054196143.1
    XP_054196144.1
    XP_054196145.1
    XP_054196146.1
    XP_054196147.1
    XP_054196148.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051022.1 RefSeqGene

      Range
      5629..64415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001173476.2 → NP_001166947.1  striated muscle preferentially expressed protein kinase isoform 4

      See identical proteins and their annotated locations for NP_001166947.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1. This variant corresponds to the mouse APEG-1 variant described in PubMed ID: 10973969.
      Source sequence(s)
      AC053503, BM677138, DA063220
      Consensus CDS
      CCDS54432.1
      UniProtKB/Swiss-Prot
      Q15772
      Related
      ENSP00000379919.1, ENST00000396688.5
      Conserved Domains (2) summary
      cd00096
      Location:20 → 22
      Ig; Ig strand A [structural motif]
      cl11960
      Location:20 → 110
      Ig; Immunoglobulin domain

    2. NM_005876.5 → NP_005867.3  striated muscle preferentially expressed protein kinase isoform 1

      See identical proteins and their annotated locations for NP_005867.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1). This variant corresponds to the mouse SPEGbeta variant described in PubMed ID: 10973969.
      Source sequence(s)
      AC053503
      Consensus CDS
      CCDS42824.1
      UniProtKB/Swiss-Prot
      A8K0G6, A8MRU0, Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9
      Related
      ENSP00000311684.7, ENST00000312358.12
      Conserved Domains (8) summary
      cd00096
      Location:1502 → 1571
      Ig; Immunoglobulin domain
      smart00408
      Location:882 → 949
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:2966 → 3218
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam07679
      Location:722 → 811
      I-set; Immunoglobulin I-set domain
      cd14108
      Location:1598 → 1854
      STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      cd14111
      Location:2962 → 3218
      STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      pfam16650
      Location:812 → 868
      SPEG_u2; Unstructured region on SPEG complex protein
      cl11960
      Location:745 → 812
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      219434843..219493629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442891.1 → XP_047298847.1  striated muscle preferentially expressed protein kinase isoform X2

    2. XM_011510479.3 → XP_011508781.1  striated muscle preferentially expressed protein kinase isoform X1

      Conserved Domains (8) summary
      cd00096
      Location:1512 → 1581
      Ig; Immunoglobulin domain
      smart00408
      Location:892 → 959
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:2976 → 3228
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam07679
      Location:732 → 821
      I-set; Immunoglobulin I-set domain
      cd14108
      Location:1608 → 1864
      STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      cd14111
      Location:2972 → 3228
      STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      pfam16650
      Location:822 → 878
      SPEG_u2; Unstructured region on SPEG complex protein
      cl11960
      Location:755 → 822
      Ig; Immunoglobulin domain

    3. XM_047442893.1 → XP_047298849.1  striated muscle preferentially expressed protein kinase isoform X4

    4. XM_047442892.1 → XP_047298848.1  striated muscle preferentially expressed protein kinase isoform X3

    5. XM_047442894.1 → XP_047298850.1  striated muscle preferentially expressed protein kinase isoform X5

    6. XM_047442895.1 → XP_047298851.1  striated muscle preferentially expressed protein kinase isoform X8

    7. XM_017003159.3 → XP_016858648.2  striated muscle preferentially expressed protein kinase isoform X12

    8. XM_047442901.1 → XP_047298857.1  striated muscle preferentially expressed protein kinase isoform X15

    9. XM_017003161.3 → XP_016858650.2  striated muscle preferentially expressed protein kinase isoform X16

    10. XM_017003162.3 → XP_016858651.2  striated muscle preferentially expressed protein kinase isoform X17

    11. XM_024452526.2 → XP_024308294.2  striated muscle preferentially expressed protein kinase isoform X19

    12. XM_047442902.1 → XP_047298858.1  striated muscle preferentially expressed protein kinase isoform X18

    13. XM_047442906.1 → XP_047298862.1  striated muscle preferentially expressed protein kinase isoform X23

    14. XM_047442903.1 → XP_047298859.1  striated muscle preferentially expressed protein kinase isoform X20

    15. XM_005246239.3 → XP_005246296.1  striated muscle preferentially expressed protein kinase isoform X11

      Conserved Domains (8) summary
      cd00096
      Location:710 → 779
      Ig; Immunoglobulin domain
      smart00408
      Location:90 → 157
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:2174 → 2426
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam07679
      Location:693 → 782
      I-set; Immunoglobulin I-set domain
      cd14108
      Location:806 → 1062
      STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      cd14111
      Location:2170 → 2426
      STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      pfam16650
      Location:20 → 76
      SPEG_u2; Unstructured region on SPEG complex protein
      cl11960
      Location:413 → 485
      Ig; Immunoglobulin domain

    16. XM_047442898.1 → XP_047298854.1  striated muscle preferentially expressed protein kinase isoform X11

    17. XM_005246237.3 → XP_005246294.1  striated muscle preferentially expressed protein kinase isoform X6

      Conserved Domains (8) summary
      cd00096
      Location:1408 → 1477
      Ig; Immunoglobulin domain
      smart00408
      Location:788 → 855
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:2872 → 3124
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam07679
      Location:628 → 717
      I-set; Immunoglobulin I-set domain
      cd14108
      Location:1504 → 1760
      STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      cd14111
      Location:2868 → 3124
      STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      pfam16650
      Location:718 → 774
      SPEG_u2; Unstructured region on SPEG complex protein
      cl11960
      Location:651 → 718
      Ig; Immunoglobulin domain

    18. XM_047442896.1 → XP_047298852.1  striated muscle preferentially expressed protein kinase isoform X9

    19. XM_006712189.4 → XP_006712252.1  striated muscle preferentially expressed protein kinase isoform X7

      Conserved Domains (8) summary
      cd00096
      Location:1398 → 1467
      Ig; Immunoglobulin domain
      smart00408
      Location:778 → 845
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:2862 → 3114
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam07679
      Location:618 → 707
      I-set; Immunoglobulin I-set domain
      cd14108
      Location:1494 → 1750
      STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      cd14111
      Location:2858 → 3114
      STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      pfam16650
      Location:708 → 764
      SPEG_u2; Unstructured region on SPEG complex protein
      cl11960
      Location:641 → 708
      Ig; Immunoglobulin domain

    20. XM_047442897.1 → XP_047298853.1  striated muscle preferentially expressed protein kinase isoform X10

    21. XM_047442917.1 → XP_047298873.1  striated muscle preferentially expressed protein kinase isoform X31

    22. XM_047442919.1 → XP_047298875.1  striated muscle preferentially expressed protein kinase isoform X31

    23. XM_047442922.1 → XP_047298878.1  striated muscle preferentially expressed protein kinase isoform X32

    24. XM_047442918.1 → XP_047298874.1  striated muscle preferentially expressed protein kinase isoform X31

    25. XM_047442921.1 → XP_047298877.1  striated muscle preferentially expressed protein kinase isoform X32

    26. XM_047442920.1 → XP_047298876.1  striated muscle preferentially expressed protein kinase isoform X31

    27. XM_047442923.1 → XP_047298879.1  striated muscle preferentially expressed protein kinase isoform X32

    28. XM_047442904.1 → XP_047298860.1  striated muscle preferentially expressed protein kinase isoform X21

    29. XM_047442908.1 → XP_047298864.1  striated muscle preferentially expressed protein kinase isoform X25

    30. XM_047442907.1 → XP_047298863.1  striated muscle preferentially expressed protein kinase isoform X24

    31. XM_047442912.1 → XP_047298868.1  striated muscle preferentially expressed protein kinase isoform X29

    32. XM_047442910.1 → XP_047298866.1  striated muscle preferentially expressed protein kinase isoform X27

    33. XM_047442905.1 → XP_047298861.1  striated muscle preferentially expressed protein kinase isoform X22

      UniProtKB/TrEMBL
      B9ZVR7
      Related
      ENSP00000379926.1, ENST00000396698.5

    34. XM_047442909.1 → XP_047298865.1  striated muscle preferentially expressed protein kinase isoform X26

    35. XM_047442914.1 → XP_047298870.1  striated muscle preferentially expressed protein kinase isoform X30

    36. XM_047442911.1 → XP_047298867.1  striated muscle preferentially expressed protein kinase isoform X28

    37. XM_047442900.1 → XP_047298856.1  striated muscle preferentially expressed protein kinase isoform X11

      Related
      ENST00000485813.5

    38. XM_006712193.4 → XP_006712256.1  striated muscle preferentially expressed protein kinase isoform X14

      See identical proteins and their annotated locations for XP_006712256.1

      Conserved Domains (7) summary
      cd00096
      Location:653 → 722
      Ig; Immunoglobulin domain
      smart00408
      Location:33 → 100
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:2117 → 2369
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam07679
      Location:636 → 725
      I-set; Immunoglobulin I-set domain
      cd14108
      Location:749 → 1005
      STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      cd14111
      Location:2113 → 2369
      STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      cl11960
      Location:356 → 428
      Ig; Immunoglobulin domain

    39. XM_005246240.2 → XP_005246297.1  striated muscle preferentially expressed protein kinase isoform X14

      See identical proteins and their annotated locations for XP_005246297.1

      Conserved Domains (7) summary
      cd00096
      Location:653 → 722
      Ig; Immunoglobulin domain
      smart00408
      Location:33 → 100
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:2117 → 2369
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam07679
      Location:636 → 725
      I-set; Immunoglobulin I-set domain
      cd14108
      Location:749 → 1005
      STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      cd14111
      Location:2113 → 2369
      STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      cl11960
      Location:356 → 428
      Ig; Immunoglobulin domain

    40. XM_005246241.2 → XP_005246298.1  striated muscle preferentially expressed protein kinase isoform X14

      See identical proteins and their annotated locations for XP_005246298.1

      Conserved Domains (7) summary
      cd00096
      Location:653 → 722
      Ig; Immunoglobulin domain
      smart00408
      Location:33 → 100
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:2117 → 2369
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam07679
      Location:636 → 725
      I-set; Immunoglobulin I-set domain
      cd14108
      Location:749 → 1005
      STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      cd14111
      Location:2113 → 2369
      STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      cl11960
      Location:356 → 428
      Ig; Immunoglobulin domain

    41. XM_005246242.5 → XP_005246299.1  striated muscle preferentially expressed protein kinase isoform X13

      Conserved Domains (8) summary
      cd00096
      Location:715 → 784
      Ig; Immunoglobulin domain
      smart00408
      Location:95 → 162
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:2179 → 2431
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam07679
      Location:698 → 787
      I-set; Immunoglobulin I-set domain
      cd14108
      Location:811 → 1067
      STKc_SPEG_rpt1; Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      cd14111
      Location:2175 → 2431
      STKc_SPEG_rpt2; Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase
      pfam16650
      Location:27 → 81
      SPEG_u2; Unstructured region on SPEG complex protein
      cl11960
      Location:418 → 490
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      219919623..219978369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340134.1 → XP_054196109.1  striated muscle preferentially expressed protein kinase isoform X2

    2. XM_054340133.1 → XP_054196108.1  striated muscle preferentially expressed protein kinase isoform X1

    3. XM_054340136.1 → XP_054196111.1  striated muscle preferentially expressed protein kinase isoform X4

    4. XM_054340135.1 → XP_054196110.1  striated muscle preferentially expressed protein kinase isoform X3

    5. XM_054340137.1 → XP_054196112.1  striated muscle preferentially expressed protein kinase isoform X5

    6. XM_054340140.1 → XP_054196115.1  striated muscle preferentially expressed protein kinase isoform X8

    7. XM_054340145.1 → XP_054196120.1  striated muscle preferentially expressed protein kinase isoform X12

    8. XM_054340151.1 → XP_054196126.1  striated muscle preferentially expressed protein kinase isoform X15

    9. XM_054340152.1 → XP_054196127.1  striated muscle preferentially expressed protein kinase isoform X16

    10. XM_054340153.1 → XP_054196128.1  striated muscle preferentially expressed protein kinase isoform X17

    11. XM_054340155.1 → XP_054196130.1  striated muscle preferentially expressed protein kinase isoform X19

    12. XM_054340154.1 → XP_054196129.1  striated muscle preferentially expressed protein kinase isoform X18

    13. XM_054340159.1 → XP_054196134.1  striated muscle preferentially expressed protein kinase isoform X23

    14. XM_054340156.1 → XP_054196131.1  striated muscle preferentially expressed protein kinase isoform X20

    15. XM_054340138.1 → XP_054196113.1  striated muscle preferentially expressed protein kinase isoform X6

    16. XM_054340169.1 → XP_054196144.1  striated muscle preferentially expressed protein kinase isoform X31

    17. XM_054340168.1 → XP_054196143.1  striated muscle preferentially expressed protein kinase isoform X31

    18. XM_054340161.1 → XP_054196136.1  striated muscle preferentially expressed protein kinase isoform X25

    19. XM_054340165.1 → XP_054196140.1  striated muscle preferentially expressed protein kinase isoform X29

    20. XM_054340172.1 → XP_054196147.1  striated muscle preferentially expressed protein kinase isoform X32

    21. XM_054340144.1 → XP_054196119.1  striated muscle preferentially expressed protein kinase isoform X11

    22. XM_054340143.1 → XP_054196118.1  striated muscle preferentially expressed protein kinase isoform X11

    23. XM_054340141.1 → XP_054196116.1  striated muscle preferentially expressed protein kinase isoform X9

    24. XM_054340139.1 → XP_054196114.1  striated muscle preferentially expressed protein kinase isoform X7

    25. XM_054340142.1 → XP_054196117.1  striated muscle preferentially expressed protein kinase isoform X10

    26. XM_054340158.1 → XP_054196133.1  striated muscle preferentially expressed protein kinase isoform X22

      UniProtKB/TrEMBL
      B9ZVR7

    27. XM_054340167.1 → XP_054196142.1  striated muscle preferentially expressed protein kinase isoform X31

    28. XM_054340171.1 → XP_054196146.1  striated muscle preferentially expressed protein kinase isoform X32

    29. XM_054340170.1 → XP_054196145.1  striated muscle preferentially expressed protein kinase isoform X31

    30. XM_054340173.1 → XP_054196148.1  striated muscle preferentially expressed protein kinase isoform X32

    31. XM_054340157.1 → XP_054196132.1  striated muscle preferentially expressed protein kinase isoform X21

    32. XM_054340160.1 → XP_054196135.1  striated muscle preferentially expressed protein kinase isoform X24

    33. XM_054340163.1 → XP_054196138.1  striated muscle preferentially expressed protein kinase isoform X27

    34. XM_054340162.1 → XP_054196137.1  striated muscle preferentially expressed protein kinase isoform X26

    35. XM_054340166.1 → XP_054196141.1  striated muscle preferentially expressed protein kinase isoform X30

    36. XM_054340164.1 → XP_054196139.1  striated muscle preferentially expressed protein kinase isoform X28

    37. XM_054340146.1 → XP_054196121.1  striated muscle preferentially expressed protein kinase isoform X11

    38. XM_054340150.1 → XP_054196125.1  striated muscle preferentially expressed protein kinase isoform X14

    39. XM_054340148.1 → XP_054196123.1  striated muscle preferentially expressed protein kinase isoform X14

    40. XM_054340149.1 → XP_054196124.1  striated muscle preferentially expressed protein kinase isoform X14

    41. XM_054340147.1 → XP_054196122.1  striated muscle preferentially expressed protein kinase isoform X13

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15772.4 GenPept UniProtKB/Swiss-Prot:Q15772

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