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    LOC126805740 CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:59764225-59765424 [ Homo sapiens (human) ]

    Gene ID: 126805740, updated on 10-Oct-2023

    Summary

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    Gene symbol
    LOC126805740
    Gene description
    CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:59764225-59765424
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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    Genomic context

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    Location:
    chromosome: 1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (59298553..59299752)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (59176925..59178124)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:59604949-59605450 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:59605451-59605950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 939 Neighboring gene uncharacterized LOC729467 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:59672311-59672933 Neighboring gene Sharpr-MPRA regulatory region 10857 Neighboring gene Sharpr-MPRA regulatory region 13133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 941 Neighboring gene FGGY divergent transcript Neighboring gene FGGY carbohydrate kinase domain containing Neighboring gene MPRA-validated peak254 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_8792 Neighboring gene MPRA-validated peak255 silencer Neighboring gene uncharacterized LOC124904192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1110 Neighboring gene MPRA-validated peak256 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:60134970-60135524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:60139185-60139712 Neighboring gene Sharpr-MPRA regulatory region 6224 Neighboring gene microRNA 4711

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_082064.1 

      Range
      101..1300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      59298553..59299752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      59176925..59178124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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