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    LRRC74A leucine rich repeat containing 74A [ Homo sapiens (human) ]

    Gene ID: 145497, updated on 5-Mar-2024

    Summary

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    Official Symbol
    LRRC74Aprovided by HGNC
    Official Full Name
    leucine rich repeat containing 74Aprovided by HGNC
    Primary source
    HGNC:HGNC:23346
    See related
    Ensembl:ENSG00000100565 AllianceGenome:HGNC:23346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LRRC74; C14orf166B
    Expression
    Restricted expression toward testis (RPKM 2.8) See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    14q24.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (76826408..76870304)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (71036112..71080030)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77292751..77336647)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5958 Neighboring gene vasohibin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77241882-77242840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8772 Neighboring gene VASH1 antisense RNA 1 Neighboring gene angel homolog 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77278266-77278840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77278841-77279414 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:77288377-77289157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77294675-77295362 Neighboring gene Sharpr-MPRA regulatory region 2360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77350573-77351390 Neighboring gene RN7SK pseudogene 17 Neighboring gene ribosomal protein L22 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 74A
    Names
    leucine rich repeat containing 74
    leucine-rich repeat-containing protein 74

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385106.1 → NP_001372035.1  leucine-rich repeat-containing protein 74A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AF111169
      Consensus CDS
      CCDS91911.1
      UniProtKB/TrEMBL
      A0A8I5KUZ3, A0A8I5KW16
      Related
      ENSP00000509938.1, ENST00000689127.1
      Conserved Domains (2) summary
      sd00033
      Location:119 → 141
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:95 → 351
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. NM_001385107.1 → NP_001372036.1  leucine-rich repeat-containing protein 74A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AF111169
      Conserved Domains (2) summary
      sd00033
      Location:119 → 141
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:95 → 344
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    3. NM_001385108.1 → NP_001372037.1  leucine-rich repeat-containing protein 74A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AF111169
      Consensus CDS
      CCDS91912.1
      UniProtKB/TrEMBL
      A0A8I5KUH5
      Related
      ENSP00000509131.1, ENST00000691684.1
      Conserved Domains (2) summary
      sd00033
      Location:119 → 141
      LRR_RI; leucine-rich repeat [structural motif]
      cl39015
      Location:95 → 307
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    4. NM_194287.3 → NP_919263.2  leucine-rich repeat-containing protein 74A isoform 1

      See identical proteins and their annotated locations for NP_919263.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF111169, BC121159, DB337977, DC397584
      Consensus CDS
      CCDS9853.2
      UniProtKB/Swiss-Prot
      Q0VAA2, Q6ZUG6, Q9Y627
      Related
      ENSP00000377369.3, ENST00000393774.7
      Conserved Domains (2) summary
      sd00033
      Location:136 → 158
      LRR_RI; leucine-rich repeat [structural motif]
      cl42388
      Location:112 → 368
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RNA

    1. NR_169572.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF111169
      Related
      ENST00000484640.6

    2. NR_169573.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF111169
      Related
      ENST00000216450.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      76826408..76870304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021035.3 → XP_016876524.1  leucine-rich repeat-containing protein 74A isoform X1

    2. XM_047431012.1 → XP_047286968.1  leucine-rich repeat-containing protein 74A isoform X2

    3. XM_047431013.1 → XP_047286969.1  leucine-rich repeat-containing protein 74A isoform X3

    4. XM_047431014.1 → XP_047286970.1  leucine-rich repeat-containing protein 74A isoform X4

      Related
      ENST00000557453.6

    5. XM_047431015.1 → XP_047286971.1  leucine-rich repeat-containing protein 74A isoform X6

    6. XM_011536487.2 → XP_011534789.2  leucine-rich repeat-containing protein 74A isoform X5

    7. XM_047431016.1 → XP_047286972.1  leucine-rich repeat-containing protein 74A isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      71036112..71080030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375466.1 → XP_054231441.1  leucine-rich repeat-containing protein 74A isoform X1

    2. XM_054375467.1 → XP_054231442.1  leucine-rich repeat-containing protein 74A isoform X2

    3. XM_054375468.1 → XP_054231443.1  leucine-rich repeat-containing protein 74A isoform X3

    4. XM_054375469.1 → XP_054231444.1  leucine-rich repeat-containing protein 74A isoform X4

    5. XM_054375471.1 → XP_054231446.1  leucine-rich repeat-containing protein 74A isoform X6

    6. XM_054375470.1 → XP_054231445.1  leucine-rich repeat-containing protein 74A isoform X5

    7. XM_054375472.1 → XP_054231447.1  leucine-rich repeat-containing protein 74A isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VAA2.2 GenPept UniProtKB/Swiss-Prot:Q0VAA2

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