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    PPRC1 PPARG related coactivator 1 [ Homo sapiens (human) ]

    Gene ID: 23082, updated on 7-Apr-2024

    Summary

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    Official Symbol
    PPRC1provided by HGNC
    Official Full Name
    PPARG related coactivator 1provided by HGNC
    Primary source
    HGNC:HGNC:30025
    See related
    Ensembl:ENSG00000148840 MIM:617462; AllianceGenome:HGNC:30025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRC
    Summary
    The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
    Expression
    Ubiquitous expression in gall bladder (RPKM 7.9), appendix (RPKM 7.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10q24.32
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (102119889..102150333)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103005469..103035313)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103892797..103910090)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene armadillo like helical domain containing 3 Neighboring gene uncharacterized LOC124902492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2735 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103698366-103699565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103795088-103795895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2737 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2738 Neighboring gene HPS6 biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103867277-103867778 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103870016-103871215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2739 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2741 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103876901-103877603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103877604-103878305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2745 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103880011-103880762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:103880763-103881514 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:103881515-103882264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103887116-103887946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2750 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103897995-103899194 Neighboring gene LIM domain binding 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103911632-103912831 Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2751 Neighboring gene ELOVL fatty acid elongase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma. Ruan X, et al. Medicina (Kaunas), 2023 Apr 17. PMID 37109742, Free PMC Article
    2. A novel PPRC1 point mutation in a Chinese family with premature ovarian failure: A case study. Zhang XJ, et al. J Gene Med, 2021 Jun. PMID 33818872
    3. Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence. Gleyzer N, et al. J Biol Chem, 2013 Mar 22. PMID 23364789, Free PMC Article
    4. PGC-1-related coactivator modulates mitochondrial-nuclear crosstalk through endogenous nitric oxide in a cellular model of oncocytic thyroid tumours. Raharijaona M, et al. PLoS One, 2009 Nov 23. PMID 19956726, Free PMC Article
    5. Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner. Yamagata K, et al. Int J Mol Med, 2007 May. PMID 17390079

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma.
      Title: Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma.
    2. A novel PPRC1 point mutation in a Chinese family with premature ovarian failure: A case study.
      Title: A novel PPRC1 point mutation in a Chinese family with premature ovarian failure: A case study.
    3. PRC and c-MYC can act in concert through Akt-GSK-3 signaling to reprogram gene expression in response to mitochondrial stress.
      Title: Concerted Action of PGC-1-related Coactivator (PRC) and c-MYC in the Stress Response to Mitochondrial Dysfunction.
    4. PRC is a negative regulator of endothelial inflammation; it negatively regulates endothelial adhesion of monocytes via inhibition of NF kappaB activity
      Title: PGC-1-related coactivator (PRC) negatively regulates endothelial adhesion of monocytes via inhibition of NF κB activity.
    5. A general role for PRC in the adaptive response to cellular dysfunction.
      Title: Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence.
    6. PRC has a role in the rapid modulation of metabolic functions in response to the status of the cell cycle
      Title: PGC-1-related coactivator modulates mitochondrial-nuclear crosstalk through endogenous nitric oxide in a cellular model of oncocytic thyroid tumours.
    7. support a role for PRC in the integration of pathways directing mitochondrial respiratory function and cell growth
      Title: Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria.
    8. Meta-analysis of gene-disease association. (HuGE Navigator)
      Title: Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
    10. The results are consistent with a pathway whereby PRC regulates NRF-2-dependent genes through a multiprotein complex involving HCF-1.
      Title: PGC-1-related coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)-dependent respiratory gene expression.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0595, MGC74642, RP11-302K17.6

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peroxisome proliferator-activated receptor gamma coactivator-related protein 1
    Names
    PGC-1-related coactivator
    peroxisome proliferator-activated receptor gamma, coactivator-related 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047132.2 RefSeqGene

      Range
      18153..35446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001288727.2 → NP_001275656.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AB011167, BU742486, HY023373
      Consensus CDS
      CCDS73186.1
      UniProtKB/TrEMBL
      B4DSS0, E7EVG6
      Related
      ENSP00000399743.2, ENST00000413464.6
      Conserved Domains (1) summary
      cd12624
      Location:1277 → 1367
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    2. NM_001288728.2 → NP_001275657.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001275657.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and initiates translation at an alternate start codon, which leads to a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB011167, AF325193, BC063806, BU742486, HY023373
      UniProtKB/TrEMBL
      B4DSS0
      Conserved Domains (1) summary
      cd12624
      Location:1419 → 1509
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    3. NM_015062.5 → NP_055877.3  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 1

      See identical proteins and their annotated locations for NP_055877.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB011167, BU742486, HY023373
      Consensus CDS
      CCDS7529.1
      UniProtKB/Swiss-Prot
      Q5VV66, Q5VV67, Q6P3U5, Q6P3W1, Q76N31, Q9BUJ3, Q9BZE5, Q9Y4E0
      UniProtKB/TrEMBL
      B4DSS0
      Related
      ENSP00000278070.2, ENST00000278070.7
      Conserved Domains (1) summary
      cd12624
      Location:1541 → 1631
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      102119889..102150333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424879.1 → XP_047280835.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    2. XM_024447914.2 → XP_024303682.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

      UniProtKB/TrEMBL
      B4DSS0
      Conserved Domains (2) summary
      cd12624
      Location:1462 → 1552
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
      cl26464
      Location:531 → 1123
      Atrophin-1; Atrophin-1 family

    3. XM_047424878.1 → XP_047280834.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    4. XM_024447917.2 → XP_024303685.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

      UniProtKB/TrEMBL
      B4DSS0
      Conserved Domains (2) summary
      cd12624
      Location:1462 → 1552
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
      cl26464
      Location:531 → 1123
      Atrophin-1; Atrophin-1 family

    5. XM_024447915.2 → XP_024303683.2  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1

    6. XM_047424885.1 → XP_047280841.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X13

    7. XM_017015982.2 → XP_016871471.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X2

      UniProtKB/TrEMBL
      B4DSS0

    8. XM_017015984.2 → XP_016871473.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X14

      UniProtKB/TrEMBL
      B4DSS0

    9. XM_011539549.3 → XP_011537851.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X3

      UniProtKB/TrEMBL
      B4DSS0
      Conserved Domains (1) summary
      cd12624
      Location:1498 → 1588
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    10. XM_047424876.1 → XP_047280832.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X4

    11. XM_017015983.2 → XP_016871472.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X5

      UniProtKB/TrEMBL
      B4DSS0

    12. XM_047424877.1 → XP_047280833.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

    13. XM_011539551.3 → XP_011537853.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X8

      UniProtKB/TrEMBL
      B4DSS0
      Conserved Domains (1) summary
      cd12624
      Location:1458 → 1548
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    14. XM_047424880.1 → XP_047280836.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X9

    15. XM_047424886.1 → XP_047280842.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X15

    16. XM_047424881.1 → XP_047280837.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X10

    17. XM_047424882.1 → XP_047280838.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X11

    18. XM_047424887.1 → XP_047280843.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X16

    19. XM_006717731.4 → XP_006717794.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X17

      UniProtKB/TrEMBL
      B4DSS0
      Conserved Domains (1) summary
      PHA03247
      Location:610 → 1136
      PHA03247; large tegument protein UL36; Provisional

    20. XM_047424884.1 → XP_047280840.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X12

    21. XM_024447916.2 → XP_024303684.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

      UniProtKB/TrEMBL
      B4DSS0
      Conserved Domains (2) summary
      cd12624
      Location:1462 → 1552
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
      cl26464
      Location:531 → 1123
      Atrophin-1; Atrophin-1 family

    22. XM_047424883.1 → XP_047280839.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X12

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      103005469..103035313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365301.1 → XP_054221276.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    2. XM_054365303.1 → XP_054221278.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    3. XM_054365302.1 → XP_054221277.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    4. XM_054365304.1 → XP_054221279.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    5. XM_054365295.1 → XP_054221270.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1

    6. XM_054365312.1 → XP_054221287.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X13

    7. XM_054365296.1 → XP_054221271.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X2

    8. XM_054365313.1 → XP_054221288.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X14

    9. XM_054365297.1 → XP_054221272.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X3

    10. XM_054365298.1 → XP_054221273.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X4

    11. XM_054365299.1 → XP_054221274.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X5

    12. XM_054365300.1 → XP_054221275.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

    13. XM_054365305.1 → XP_054221280.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X8

    14. XM_054365306.1 → XP_054221281.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X9

    15. XM_054365314.1 → XP_054221289.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X15

    16. XM_054365307.1 → XP_054221282.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X10

    17. XM_054365308.1 → XP_054221283.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X11

    18. XM_054365315.1 → XP_054221290.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X16

    19. XM_054365316.1 → XP_054221291.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X17

    20. XM_054365310.1 → XP_054221285.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X12

    21. XM_054365311.1 → XP_054221286.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    22. XM_054365309.1 → XP_054221284.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X12

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VV67.1 GenPept UniProtKB/Swiss-Prot:Q5VV67

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