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    SNHG32 small nucleolar RNA host gene 32 [ Homo sapiens (human) ]

    Gene ID: 50854, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SNHG32provided by HGNC
    Official Full Name
    small nucleolar RNA host gene 32provided by HGNC
    Primary source
    HGNC:HGNC:19078
    See related
    Ensembl:ENSG00000204387 MIM:605447; AllianceGenome:HGNC:19078
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G8; D6S57; C6orf48
    Summary
    Predicted to enable double-stranded RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 167.3), thyroid (RPKM 84.5) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    6p21.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (31834916..31839761)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (31687976..31692820)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31802693..31807538)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene origin of replication in promoter of HSPA1A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31783959-31784528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31784529-31785098 Neighboring gene heat shock protein family A (Hsp70) member 1A Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:31789548-31790747 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:31794443-31795254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31795278-31795907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31795908-31796536 Neighboring gene heat shock protein family A (Hsp70) member 1B Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:31801830-31802528 Neighboring gene small nucleolar RNA, C/D box 48 Neighboring gene small nucleolar RNA, C/D box 52 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:31830779-31831404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31831405-31832028 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31832029-31832653 Neighboring gene neuraminidase 1 Neighboring gene solute carrier family 44 member 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31838055-31838988 Neighboring gene EHMT2 and SLC44A4 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. HLA-linked heat-shock protein 70 (HSP70-2) gene polymorphism and celiac disease. Partanen J, et al. Tissue Antigens, 1993 Jan. PMID 8096093
    2. Long non-coding RNA SNHG3 promotes progression of gastric cancer by regulating neighboring MED18 gene methylation. Xuan Y, et al. Cell Death Dis, 2019 Sep 18. PMID 31534128, Free PMC Article
    3. Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population. Pan Q, et al. Genet Mol Res, 2012 Dec 17. PMID 23079975
    4. Common genetic variation and the control of HIV-1 in humans. Fellay J, et al. PLoS Genet, 2009 Dec. PMID 20041166, Free PMC Article
    5. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Weinmann L, et al. Cell, 2009 Feb 6. PMID 19167051

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA SNHG3 promotes progression of gastric cancer by regulating neighboring MED18 gene methylation.
      Title: Long non-coding RNA SNHG3 promotes progression of gastric cancer by regulating neighboring MED18 gene methylation.
    2. Single nucleotide polymorphisms at C6orf48, BAT2 and ZBTB12 are associated with estrogen receptor positive breast cancer in the Chinese Han population.
      Title: Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population.
    3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variation and the control of HIV-1 in humans.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • protein G8

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_160945.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671762
      Related
      ENST00000648677.1

    2. NR_160946.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671762
      Related
      ENST00000375642.6

    3. NR_160947.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671762

    4. NR_160948.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671762
      Related
      ENST00000614363.4

    5. NR_160949.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671762
      Related
      ENST00000375638.7

    6. NR_160950.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671762

    7. NR_160951.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671762

    8. NR_160952.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671762
      Related
      ENST00000375635.6

    9. NR_160953.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671762

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      31834916..31839761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      3167531..3172376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      3312163..3317005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      3082695..3087539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      3090756..3095597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      31687976..31692820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001040437.2: Suppressed sequence

      Description
      NM_001040437.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    2. NM_001040438.2: Suppressed sequence

      Description
      NM_001040438.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    3. NM_001287482.1: Suppressed sequence

      Description
      NM_001287482.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    4. NM_001287483.1: Suppressed sequence

      Description
      NM_001287483.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    5. NM_001287484.1: Suppressed sequence

      Description
      NM_001287484.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    6. NM_001287485.1: Suppressed sequence

      Description
      NM_001287485.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    7. NM_001287486.1: Suppressed sequence

      Description
      NM_001287486.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    8. NM_001287487.1: Suppressed sequence

      Description
      NM_001287487.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    9. NM_001287488.1: Suppressed sequence

      Description
      NM_001287488.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    10. NM_016947.1: Suppressed sequence

      Description
      NM_016947.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version

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