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    CDH26 cadherin 26 [ Homo sapiens (human) ]

    Gene ID: 60437, updated on 2-May-2024

    Summary

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    Official Symbol
    CDH26provided by HGNC
    Official Full Name
    cadherin 26provided by HGNC
    Primary source
    HGNC:HGNC:15902
    See related
    Ensembl:ENSG00000124215 MIM:617685; AllianceGenome:HGNC:15902
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VR20
    Summary
    This gene encodes a member of the cadherin protein family. Cadherins are a family of calcium-dependent adhesion molecules that mediate cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization, migration and differentiation. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. This protein is expressed in gastrointestinal epithelial cells and may be upregulated during allergic inflammation. This protein interacts with alpha integrins and may also be involved in leukocyte migration and adhesion. [provided by RefSeq, Jan 2017]
    Expression
    Biased expression in prostate (RPKM 2.7), urinary bladder (RPKM 1.4) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    20q13.33
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (59958423..60035934)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (61742679..61822261)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (58533478..58589584)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene synaptonemal complex protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13091 Neighboring gene Sharpr-MPRA regulatory region 25 Neighboring gene family with sequence similarity 217 member B Neighboring gene protein phosphatase 1 regulatory subunit 3D Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:58529519-58530020 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:58569287-58569819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:58611565-58612066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:58612067-58612566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18193 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:58633003-58633804 Neighboring gene long intergenic non-protein coding RNA 2910 Neighboring gene uncharacterized LOC729296

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Epithelial cell-adhesion protein cadherin 26 is dysregulated in congenital diaphragmatic hernia and congenital pulmonary airway malformation. Wagner R, et al. Pediatr Surg Int, 2021 Jan. PMID 33161446
    2. Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis. Liu T, et al. Laryngoscope, 2023 Jul. PMID 36069256
    3. Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation. Caldwell JM, et al. Mucosal Immunol, 2017 Sep. PMID 28051089, Free PMC Article
    4. Association and interaction analyses of eight genes under asthma linkage peaks. Ferreira MA, et al. Allergy, 2009 Nov. PMID 19824886
    5. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. Nollet F, et al. J Mol Biol, 2000 Jun 9. PMID 10835267

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis.
      Title: Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis.
    2. Epithelial cell-adhesion protein cadherin 26 is dysregulated in congenital diaphragmatic hernia and congenital pulmonary airway malformation.
      Title: Epithelial cell-adhesion protein cadherin 26 is dysregulated in congenital diaphragmatic hernia and congenital pulmonary airway malformation.
    3. this study shows that cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation
      Title: Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
      Title: Association and interaction analyses of eight genes under asthma linkage peaks.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-catenin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables delta-catenin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CD4-positive, alpha-beta T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cadherin-like protein 26
    Names
    cadherin-like 26
    cadherin-like protein VR20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348204.2 → NP_001335133.1  cadherin-like protein 26 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) use an alternate exon in the 5' UTR and 5' coding region and lacks a large portion of the 5' coding region, compared to variant a. The encoded isoform (c) has a a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AK074477, AL109928, BC062570
      Consensus CDS
      CCDS86964.1
      UniProtKB/Swiss-Prot
      Q8IXH8
      Related
      ENSP00000244049.3, ENST00000244049.7
      Conserved Domains (1) summary
      pfam01049
      Location:46 → 120
      Cadherin_C; Cadherin cytoplasmic region

    2. NM_021810.6 → NP_068582.2  cadherin-like protein 26 isoform b

      See identical proteins and their annotated locations for NP_068582.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) use an alternate exon in the 5' UTR and 5' coding region and lacks a large portion of the 5' coding region, compared to variant a. The encoded isoform (b) has a a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AK074477, AL109928
      Consensus CDS
      CCDS13486.1
      UniProtKB/Swiss-Prot
      Q8IXH8
      Related
      ENSP00000310845.7, ENST00000350849.10
      Conserved Domains (1) summary
      pfam01049
      Location:63 → 150
      Cadherin_C; Cadherin cytoplasmic region

    3. NM_177980.4 → NP_817089.1  cadherin-like protein 26 isoform a precursor

      See identical proteins and their annotated locations for NP_817089.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK055202, AK074477, AL109928, DB234033
      Consensus CDS
      CCDS13485.1
      UniProtKB/Swiss-Prot
      A2A2M5, B3KNX3, Q6P5Y6, Q8IXH8, Q8TCH3, Q9BQN4, Q9NRU1
      UniProtKB/TrEMBL
      B9EG96
      Related
      ENSP00000339390.4, ENST00000348616.9
      Conserved Domains (2) summary
      cd11304
      Location:169 → 271
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam01049
      Location:726 → 828
      Cadherin_C; Cadherin cytoplasmic region

    RNA

    1. NR_145482.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) uses an alternate splice site compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK074477, AL109928, BC143931, DB234033

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      59958423..60035934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528970.4 → XP_011527272.1  cadherin-like protein 26 isoform X1

      Conserved Domains (1) summary
      cd11304
      Location:156 → 245
      Cadherin_repeat; Cadherin tandem repeat domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      61742679..61822261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323793.1 → XP_054179768.1  cadherin-like protein 26 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IXH8.4 GenPept UniProtKB/Swiss-Prot:Q8IXH8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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