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    TPC1 thiamine transporter TPC1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852988, updated on 17-May-2024

    Summary

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    Gene symbol
    TPC1
    Gene description
    thiamine transporter TPC1
    Primary source
    FungiDB:YGR096W
    Locus tag
    YGR096W
    See related
    SGD:S000003328; AllianceGenome:SGD:S000003328
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables thiamine pyrophosphate transmembrane transporter activity. Involved in mitochondrial thiamine pyrophosphate transmembrane transport. Is integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in inherited metabolic disorder and microcephaly. Orthologous to human SLC25A19 (solute carrier family 25 member 19). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TPC1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (676621..677565)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene valine--tRNA ligase Neighboring gene exosome non-catalytic core subunit RRP46 Neighboring gene Ask10p Neighboring gene separase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate. Marobbio CM, et al. EMBO J, 2002 Nov 1. PMID 12411483, Free PMC Article
    2. Thiamine increases the resistance of baker's yeast Saccharomyces cerevisiae against oxidative, osmotic and thermal stress, through mechanisms partly independent of thiamine diphosphate-bound enzymes. Wolak N, et al. FEMS Yeast Res, 2014 Dec. PMID 25331172
    3. Identification of mitochondrial thiamin diphosphate carriers from Arabidopsis and maize. Frelin O, et al. Funct Integr Genomics, 2012 Jun. PMID 22426856
    4. The biochemical properties of the mitochondrial thiamine pyrophosphate carrier from Drosophila melanogaster. Iacopetta D, et al. FEBS J, 2010 Mar. PMID 20121944
    5. The yeast mitochondrial transport proteins: new sequences and consensus residues, lack of direct relation between consensus residues and transmembrane helices, expression patterns of the transport protein genes, and protein-protein interactions with other proteins. Belenkiy R, et al. Biochim Biophys Acta, 2000 Jul 31. PMID 10930523

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables thiamine pyrophosphate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiamine pyrophosphate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial thiamine pyrophosphate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial thiamine pyrophosphate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thiamine pyrophosphate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thiamine transporter TPC1
    NP_011610.3
    • Mitochondrial membrane transporter; mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      676621..677565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181225.3 → NP_011610.3  TPA: thiamine transporter TPC1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011610.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZV78, D6VUM8, P53257, Q6B1H1
      UniProtKB/TrEMBL
      A0A8H4C2B5, B3LID0, B5VJ43, C7GWW7, C8Z8Z0, N1P9W1
      Conserved Domains (2) summary
      PTZ00169
      Location:21 → 285
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:16 → 105
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53257.1

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