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    SOCS6 suppressor of cytokine signaling 6 [ Homo sapiens (human) ]

    Gene ID: 9306, updated on 11-Apr-2024

    Summary

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    Official Symbol
    SOCS6provided by HGNC
    Official Full Name
    suppressor of cytokine signaling 6provided by HGNC
    Primary source
    HGNC:HGNC:16833
    See related
    Ensembl:ENSG00000170677 MIM:605118; AllianceGenome:HGNC:16833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CIS4; SSI4; CIS-4; SOCS4; STAI4; SOCS-4; SOCS-6; STATI4; HSPC060
    Summary
    The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in small intestine (RPKM 4.2), colon (RPKM 3.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    18q22.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (70289045..70330199)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (70504115..70545262)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (67956281..67997435)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372180 Neighboring gene uncharacterized LOC124904321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:67904225-67904725 Neighboring gene uncharacterized LOC107985158 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:67944250-67944750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9540 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:67960199-67960375 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:68004081-68005280 Neighboring gene long intergenic non-protein coding RNA 1909 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:68015472-68016064 Neighboring gene liver cell viability associated lncRNA Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:68024559-68025758 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:68033479-68034190 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:68034191-68034901 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:68051227-68052426 Neighboring gene long intergenic non-protein coding RNA 1910

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of SOCS6: an unfavorable prognostic factor for gastrointestinal stromal tumor proven by survival analysis. Ouyang J, et al. Diagn Pathol, 2021 Dec 12. PMID 34895274, Free PMC Article
    2. Inhibition of SOCS6 confers radioresistance in esophageal squamous cell carcinoma. Ma R, et al. Biochem Biophys Res Commun, 2021 Apr 23. PMID 33689885
    3. SOCS6 Functions as a Tumor Suppressor by Inducing Apoptosis and Inhibiting Angiogenesis in Human Prostate Cancer. Yuan D, et al. Curr Cancer Drug Targets, 2018. PMID 29295692
    4. MicroRNA-424-5p suppresses the expression of SOCS6 in pancreatic cancer. Wu K, et al. Pathol Oncol Res, 2013 Oct. PMID 23653113
    5. Array-comparative genomic hybridization reveals loss of SOCS6 is associated with poor prognosis in primary lung squamous cell carcinoma. Sriram KB, et al. PLoS One, 2012. PMID 22363434, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Extracellular vesicle-encapsulated microRNA-296-3p from cancer-associated fibroblasts promotes ovarian cancer development through regulation of the PTEN/AKT and SOCS6/STAT3 pathways.
      Title: Extracellular vesicle-encapsulated microRNA-296-3p from cancer-associated fibroblasts promotes ovarian cancer development through regulation of the PTEN/AKT and SOCS6/STAT3 pathways.
    2. Methyltransferase-like 3 facilitates lung cancer progression by accelerating m6A methylation-mediated primary miR-663 processing and impeding SOCS6 expression.
      Title: Methyltransferase-like 3 facilitates lung cancer progression by accelerating m6A methylation-mediated primary miR-663 processing and impeding SOCS6 expression.
    3. MicroRNA-494-3p Exacerbates Renal Epithelial Cell Dysfunction by Targeting SOCS6 under High Glucose Treatment.
      Title: MicroRNA-494-3p Exacerbates Renal Epithelial Cell Dysfunction by Targeting SOCS6 under High Glucose Treatment.
    4. Down-regulation of SOCS6: an unfavorable prognostic factor for gastrointestinal stromal tumor proven by survival analysis.
      Title: Down-regulation of SOCS6: an unfavorable prognostic factor for gastrointestinal stromal tumor proven by survival analysis.
    5. Circ_0085289 Alleviates the Progression of Periodontitis by Regulating let-7f-5p/SOCS6 Pathway.
      Title: Circ_0085289 Alleviates the Progression of Periodontitis by Regulating let-7f-5p/SOCS6 Pathway.
    6. Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6.
      Title: Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6.
    7. Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6.
      Title: Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6.
    8. Inhibition of SOCS6 confers radioresistance in esophageal squamous cell carcinoma.
      Title: Inhibition of SOCS6 confers radioresistance in esophageal squamous cell carcinoma.
    9. miR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6.
      Title: miR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6.
    10. microRNA-454 promotes liver tumor-initiating cell expansion by regulating SOCS6.
      Title: microRNA-454 promotes liver tumor-initiating cell expansion by regulating SOCS6.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of cytokine signaling 6
    Names
    STAT induced STAT inhibitor-4
    cytokine-inducible SH2 protein 4
    suppressor of cytokine signaling 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004232.4 → NP_004223.2  suppressor of cytokine signaling 6

      See identical proteins and their annotated locations for NP_004223.2

      Status: REVIEWED

      Source sequence(s)
      AC023395, BC020082
      Consensus CDS
      CCDS11998.1
      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
      Related
      ENSP00000381034.3, ENST00000397942.4
      Conserved Domains (2) summary
      cd10387
      Location:373 → 472
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:495 → 535
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      70289045..70330199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026087.2 → XP_016881576.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
      Conserved Domains (2) summary
      cd10387
      Location:373 → 472
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:495 → 535
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

    2. XM_047437940.1 → XP_047293896.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3

    3. XM_005266783.5 → XP_005266840.1  suppressor of cytokine signaling 6 isoform X1

      See identical proteins and their annotated locations for XP_005266840.1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
      Conserved Domains (2) summary
      cd10387
      Location:373 → 472
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:495 → 535
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

    4. XM_047437937.1 → XP_047293893.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3

    5. XM_047437941.1 → XP_047293897.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3

    6. XM_047437942.1 → XP_047293898.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3

    7. XM_017026086.2 → XP_016881575.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
      Conserved Domains (2) summary
      cd10387
      Location:373 → 472
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:495 → 535
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

    8. XM_047437938.1 → XP_047293894.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3
      Related
      ENSP00000463395.1, ENST00000582322.1

    9. XM_047437939.1 → XP_047293895.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/Swiss-Prot
      O14544, Q8WUM3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      70504115..70545262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016387.1: Suppressed sequence

      Description
      NM_016387.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14544.2 GenPept UniProtKB/Swiss-Prot:O14544

    Gene LinkOut

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