show Abstracthide AbstractNext-generation sequencing technology was exploited to gain deeper insight into how fruit and leaf gene networks of Citrus sinensis (sweet orange) respond to infection by Candidatus liberibacter asiaticus (CaLas), one of the causative agents of Huanglongbing disease (HLB). HLB or “citrus greening” is the most destructive citrus disease worldwide, where little is known about mechanisms of the physiological changes in infected plants.