show Abstracthide AbstractThe goal of this study is to estimate contemporary natural selection on transcript abundance and co-regulated gene networks by integrating whole-transcriptome analysis with a classical regression-based selection differentials approach. Small pelvic fin tissues were excised from 278 juvenile brown trout (fork length measured) harbouring the proliferative kidney disease (PKD, a fatal disease of salmonids caused by the parasite Tetracapsuloides bryosalmonae) and their survival and phenotypic traits (fork length, Hematocrit, kidney-to-muscle ratio as a measure of kidney swollenness and T. bryosalmonae load in kidney measured using qPCR approach) was estimated after approximately one month. Data is quantitative (transcript abundance, fork length, kidnew swollenness, parasite load) and qualitative (survival).