show Abstracthide AbstractDomestic silkworm, Bombyx mori, is used to produce silk. Also, due to developments in a transgenic technique of B. mori, B. mori is also used as a bioreactor to produce recombinant proteins in silk gland. Considering these uses, silk gene expressions are important. Silk genes are highly expressed in the silk gland of the last instar larvae, which is an important time point for silk synthesis. In this project, to reveal molecular or genetic mechanisms of silk synthesis and find genes involved in silk gene expression, RNA-Seq using silk glands of the last instar was performed to obtain time-series transcriptome data of silk grand.