2YTU


Conserved Protein Domain Family
SAM_PNT-FLI-1
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cd08541: SAM_PNT-FLI-1 
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Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
SAM Pointed domain of FLI-1 (Friend Leukemia Integration) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. The FLI-1 protein participates in regulation of cellular differentiation, proliferation, and survival. The Fli-1 gene was initially described in Friend virus-induced erythroleukemias as a site for virus integration. It is highly expressed in hematopoietic tissues and at lower level in lungs, heart, and ovaries. Fli-1 is a proto-oncogene implicated in Ewing's sarcoma and erythroleukemia. Members of this subfamily are potential targets for cancer therapy.
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Statistics
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PSSM-Id: 188883
Aligned: 4 rows
Threshold Bit Score: 196.81
Created: 4-Feb-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2YTU_A        22 PPNMTTNERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQNMDGKELCKMNKEDFLRATTLYNTEVLLSHLSY 101 human
P41157       113 PPNMTTNERRVIVPADPALWSQDHVRQWLEWAIKEYGLVEIDCSLFQNIDGKELCKMSKEDFLRSTSIYNTEVLLSHLNY 192 African clawed ...
NP_571423    113 PPNMTTNERRVIVPADPSLWSPDHVRQWLDWAIKEYGLQEIDTAMFHSTDGKELCKMSKDDFLRLTSVYNTEVLLSHLNY 192 zebrafish
NP_001026079 114 PPNMTTNERRVIVPADPTLWTQEHVRQWLEWAIKEYGLMEIDTTLFQNMDGKELCKTNKDDFLRTTSLYNTEVLLSHLSY 193 chicken

2YTU_A       102 LRESSLLAYNT 112 human
P41157       193 LRDSSSSLGYN 203 African clawed frog
NP_571423    193 LRESSSSISYN 203 zebrafish
NP_001026079 194 LRESSSLLVYN 204 chicken
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