Conserved Protein Domain Family
MH1_SMAD_6
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cd10493: MH1_SMAD_6 
N-terminal Mad Homology 1 (MH1) domain in SMAD6
The MH1 is a small DNA-binding domain present in SMAD (small mothers against decapentaplegic) family of proteins, which are signal transducers and transcriptional modulators that mediate multiple signaling pathways. MH1 binds to the DNA major groove in an unusual manner via a beta hairpin structure. It negatively regulates the functions of the MH2 domain, the C-terminal domain of SMAD. This MH1 belongs to SMAD6, an inhibitory SMAD (I-SMAD) or antagonistic SMAD, which acts as a negative regulator of signaling mediated by TGF-beta superfamily ligands, by competing with SMAD4 and preventing the transcription of SMAD4's gene products. SMAD6 specifically inhibits bone morphogenetic protein (BMP) type I receptor mediated signaling.
Links
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Statistics
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PSSM-Id: 199817
Aligned: 7 rows
Threshold Bit Score: 169.18
Created: 29-Jun-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAZn binding site
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:based on similarity to other SMAD-MH1 domains with structure bound to a palindromic SMAD binding element, GTCTAGAC
  • Comment: MH1 binds to the major groove via a beta hairpin structure
  • Citation:PMID 9741623
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #   #  #                                ##                       
O43541       160 EARSRLLLl-EQELKTVTYSLLKRLKERSLDTLLEAVESRGGvpGGCVLVpradLRLgg-qpAPPQLLLGRLFRWPDLQH 237 human
NP_001038516 152 ESKPRSVM--EQELKTATYSLLKRLKEKTLDTLLEAVESGGMp-SDCVMVsrteLRLgg-hmAPPQLLICKLYRWSDLQH 227 zebrafish
Q9W734        94 EARSRLVLl-ERELKAVTYALLKRLKERSLHSLLQAVESRGGtpGGCVLVargeLRLgaarrPPPHLLLGKLFRWPDLQH 172 chicken
NP_001019981 118 ERKTGAVT--EQELKKCTYAFLKKLKDKSLDVLLEAVESQGGmpSGCVLVsqteVRIgg-hlVSPQYLLCRLFRWPDLRL 194 zebrafish
NP_001084210  27 CGLSEQPAg-SPELRAAASAILKRLKEQTLCVLLEAVESRGAapGGCVMV----TRHg----PPPHLLLCRLFRWPELQH 97  African clawed ...
CAF99868     125 AGEPCQCAsrQEDLASTAHAFLKRLKEGNLEALARTVESKGS--SECVMVtnseLRLga-rrVSPQYLLCRMYRWSDLPV 201 spotted green p...
XP_002592698 515 CGQGKPED--DPELKSVTFSVLKRLKERQLELLVQTVESRGGleSGCVHFprpdVRIgr-rtVAPHVLTCLLWRWTDLQH 591 Florida lancelet

Feature 1        #                                     
O43541       238 AvELKPLCGCHSFaaaa--dgptVCCNPYHFSRLCGPE 273 human
NP_001038516 228 TaQLKALCECKSFgaqd---gpvVCCNPYHYSRLCGPE 262 zebrafish
Q9W734       173 PaELKALCECQSFgaad---gptVCCNPYHFSRLCGPE 207 chicken
NP_001019981 195 SsLLKPLCHCQSFraed---sqtLCCNPHHYSRLCGPV 229 zebrafish
NP_001084210  98 PgQLKALSGCQGAggsdn-nsgcCCCNPYHYSRVCEPE 134 African clawed frog
CAF99868     202 SaRLKRLCHCQSFgsve---ntdVCCNPYHYSRLCGPE 236 spotted green pufferfish
XP_002592698 592 PhQLKTLMCCQSYgqqdgdcgptVCCNPYHYTRLCGPE 629 Florida lancelet

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