3UTM


Conserved Protein Domain Family
Axin_TNKS_binding

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cd11582: Axin_TNKS_binding 
Click on image for an interactive view with Cn3D
Tankyrase binding N-terminal segment of axin
This N-terminal region of axin mediates interactions with the ankyrin-repeat clusters 2 and 3 of tankyrase, which controls the turnover of axin via poly-ADP-ribosylation. Axin functions as a negative regulator of the WNT signaling pathway.
Links
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Statistics
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PSSM-Id: 211424
Aligned: 13 rows
Threshold Bit Score: 61.2956
Created: 24-Feb-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
TNKS binding
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1: TNKS binding site [polypeptide binding site], 24 residue positions
Conserved feature residue pattern:x x x R P P V P G E E x R x x L G E P E G x x xClick to see conserved feature residue pattern help
Evidence:
  • Structure:3UTM: The N-terminus of mouse axin-1 binds the ankyrin repeat clusters 2 and 3 of tankyrase-1, contacts at 4 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                # ##   #########                                      #                 
3UTM_C        14 DLGASf-tEDAP---RPPVPGEEGElVSTDSrpvnhs----fcsgkgTSIKSEts---tATPRR---------------- 66   house mouse
AAH45281       7 DPMVSsfrEDDP---RPPVPGEEGEtTCHHPsklamm----rpkdpvKTIMADlr---cSTARR---------------- 60   zebrafish
XP_002943101  12 HLSSSf-rEDAP---RPPVPGEEGH-TPCQPpa------------rsQRSKPApv---sSNPRR---------------- 55   western clawed...
NP_989822     12 DPGSSf-rEDAP---RPPVPGEEGDaPPCPQphssf-------laksQSFPAMpv---pAAPRR---------------- 61   chicken
Q9Y2T1        12 DPSSSf-rEDAP---RPPVPGEEGEtPPCQPgvg-----------kgQVTKPMsv---sSNTRR---------------- 57   human
EFN72526       7 NEARCf-nENSP---RPPVPGEETGsYVSRI----------------RPQSPA------LTPRRssfatlh--------- 51   Camponotus flo...
XP_002427529   9 GHGDFd--ENSP---RPPVPGEETDpGCCCSntttpa-----fpnnpSVLPYK------YTPRGyn-------------- 58   human body louse
XP_002603590  11 DTGGSkftEDLPtsaRPPVPGEETEsNHGSQhsgssntk-seystksDYSKSDyshssaGTPRR---------------- 73   Florida lancelet
AAT42371      11 DSGGS---QLSE---RPPVPGEETEdRGSVSss-------------vKSGKQSdq--saGTPRRsnlkdaa--------- 60   green sea urchin
NP_001158475  11 DPGEHy-aGDVPteqRPPVPGEENIeTISNDgcsshshysnktvitkTELTHSp----aATPRRsnidqgkyasllqyhv 85   Saccoglossus k...
BAA92439      15 DLGSSf-tEDAP---RPPVPGEEGDlVSSDGrqynhs----fyssksDSLKNEas---iATPRR---------------- 67   zebrafish
NP_001089251  11 DLGGSf-tEDAP---RPPVPGEEGElITTDQrpfsht----yyslknDGIKNEts---tATPRR---------------- 63   African clawed...
AAT79417      11 DLGRSf-tEDAP---RPPVPGEEGElVSTDPrpvshg----fyssksDAVRNEts---tATPRR---------------- 63   chicken
Feature 1                   #### ###### #  
3UTM_C        67 ---------SDLDLGyEPEGSASPTP 83   house mouse
AAH45281      61 ---------DEDGLG-EPEGSASPDS 76   zebrafish
XP_002943101  56 ---------DAGGLG-EPEGSASPDS 71   western clawed frog
NP_989822     62 ---------NENGLG-EPEGSASPDS 77   chicken
Q9Y2T1        58 ---------NEDGLG-EPEGRASPDS 73   human
EFN72526      52 --assgdcdASAPLGfEPEGCCGTTT 75   Camponotus floridanus
XP_002427529  59 -------ahIPANLGfEPEGSCAYYG 77   human body louse
XP_002603590  74 ---------TNCDLGfEPEGSASPTP 90   Florida lancelet
AAT42371      61 ---ikggmlEGAPLGfEPEGSASVTP 83   green sea urchin
NP_001158475  86 qrgvkgtedIEAPLGfEPEGSASVTP 111  Saccoglossus kowalevskii
BAA92439      68 ---------PDLDLGyEPEGSASPTP 84   zebrafish
NP_001089251  64 ---------PDLDLGyEPEGSASPTP 80   African clawed frog
AAT79417      64 ---------SDLDLGyEPEGSASPTP 80   chicken

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