Conserved Protein Domain Family
ABC_MTABC3_MDL1_MDL2
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cd03249: ABC_MTABC3_MDL1_MDL2 
ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the yeast MDL1 (multidrug resistance-like protein 1) and MDL2 (multidrug resistance-like protein 2) transporters are also included in this CD. MDL1 is an ATP-dependent permease that acts as a high-copy suppressor of ATM1 and is thought to have a role in resistance to oxidative stress. Interestingly, subfamily B is more closely related to the carboxyl-terminal component of subfamily C than the two halves of ABCC molecules are with one another.
Links
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Statistics
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PSSM-Id: 213216
Aligned: 37 rows
Threshold Bit Score: 358.776
Created: 21-Apr-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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  next features
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:Walker A, Walker B, Q-loop, D-loop, and H-loop form the nucleotide binding site
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                            ## ###                                    
P21439     394 LEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLY--------------------------- 446  human
P13568     378 IEFKNVRFHYDTRKDVEIYKDLSFTLKEGKTYAFVGESGCGKSTILKLIERLY--------------------------- 430  Plasmodium falci...
P13568    1126 VDIKDVNFRYISRPNVPIYKNLSFTCDSKKTTAIVGETGSGKSTFMNLLLRFY--------------------------- 1178 Plasmodium falci...
AAA20682   493 IEFKDVSFSYPTRPSVQIFKNLNFKIAPGSSVCIVGPSGRGKSTIALLLLRYY--------------------------- 545  baker's yeast
AAA66476   442 IEFSDVKFAYPNRPETIVLNELSMFLPGGKVIALVGQSGAGKSTVVSLLERFY--------------------------- 494  Schistosoma mansoni
Q06034     391 IEFRNVRFAYPTRPGMILFRDLSLKIKCGQKVAFSGASGCGKSSVIGLIQRFY--------------------------- 443  Leishmania enrie...
AAA86667     8 IHFRHVSFRYPSRPTMPVLRDFSHTICPGETVAFVGHSGCGKTSVLNLLQRFYtigpc--------------------ds 67   liver fluke
P33310     432 IVFKNVSFTYPTRPKHQIFKDLNITIKPGEHVCAVGPSGSGKSTIASLLLRYY--------------------------- 484  baker's yeast
AAH92161   470 VDFMNISFSYPTRPGNQILKHFSLTLPPCKTVAIVGESGGGKSTVAALLERFY--------------------------- 522  zebrafish
AAZ04383  1129 VRVEKVRFRYPERPNIPVYQELSFEMKPGETVALVGASGCGKSTVVQLLERFYdlenssgvetgassdpsgprtadatre 1208 Toxoplasma gondii

Feature 1                                                                                      
P21439     447 --DPDEGTINIDGqdi-----------------------------------------------rnFNVNYLREI-IGVVS 476  human
P13568     431 --DPTEGDIIVNDshn----------------------------------------------lkdINLKWWRSK-IGVVS 461  Plasmodium falci...
P13568    1179 --DLKNDHIILKNdmtnfqdyqnnnnnslvlknvnefsnqsgsaedytvfnnngeillddinicdYNLRDLRNL-FSIVS 1255 Plasmodium falci...
AAA20682   546 --NPTTGTITIDNqdi-----------------------------------------------skLNCKSLRRH-IGIVQ 575  baker's yeast
AAA66476   495 --DPISGEILLNGdkl----------------------------------------------tnfNVNYLRSKL-IGYIS 525  Schistosoma mansoni
Q06034     444 --DPIGGAVLVDGvrm-----------------------------------------------reLCLREWRDQ-IGIVS 473  Leishmania enrie...
AAA86667    68 nrGIFVGETPLDR----------------------------------------------------LAPCWLRSQ-IGMVD 94   liver fluke
P33310     485 --DVNSGSIEFGDedi-----------------------------------------------rnFNLRKYRRL-IGYVQ 514  baker's yeast
AAH92161   523 --DPSSGVVMLDGldi-----------------------------------------------rtLDPSWLRGHvIGFIS 553  zebrafish
AAZ04383  1209 veLPRNGRITLDGidi-----------------------------------------------reINIQSLRSL-IGLVG 1240 Toxoplasma gondii

Feature 1      #                                                                               
P21439     477 QEPVLFSTTIAENICYGrgnvtmdeik---------------------------------------------kavkeana 511  human
P13568     462 QDPLLFSNSIKNNIKYSlyslkdleamenyyeentndtyenknfslisnsmtsnellemkkeyqtikdsdvvdvskkvli 541  Plasmodium falci...
P13568    1256 QEPMLFNMSIYENIKFGredatledvk---------------------------------------------rvskfaai 1290 Plasmodium falci...
AAA20682   576 QEPVLMSGTIRDNITYGltytptkeeir--------------------------------------------svakqcfc 611  baker's yeast
AAA66476   526 QEPQIFNASIRENIRFGrfdatdeevee--------------------------------------------aaklayah 561  Schistosoma mansoni
Q06034     474 QEPNLFAGTMMENVRMGkpnatdeevv---------------------------------------------eacrqani 508  Leishmania enrie...
AAA86667    95 QEPHLFDITLQKNIAYGdnerevsmeev-------------------------------------------meaarlaei 131  liver fluke
P33310     515 QEPLLFNGTILDNILYCippeiaeqddri------------------------------------------rraigkanc 552  baker's yeast
AAH92161   554 QEPVLFGTSVMENIRFGkpsatdaevv---------------------------------------------saakqana 588  zebrafish
AAZ04383  1241 QEPVLFSMSVADNIRYAkpeatleevv---------------------------------------------haaklana 1275 Toxoplasma gondii

Feature 1                                                      ##                              
P21439     512 yeFIMKLPqkFDTLVGERGAQ---LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAr--eGRTTIV 586  human
P13568     542 hdFVSSLPdkYDTLVGSNASK---LSGGQKQRISIARAIMRNPKILILDEATSSLDNKSEYLVQKTINNLkgneNRITII 618  Plasmodium falci...
P13568    1291 deFIESLPnkYDTNVGPYGKS---LSGGQKQRIAIARALLREPKILLLDEATSSLDSNSEKLIEKTIVDIkdkaDKTIIT 1367 Plasmodium falci...
AAA20682   612 hnFITKFPntYDTVIGPHGTL---LSGGQKQRIAIARALIKKPTILILDEATSALDVESEGAINYTFGQLmkskSMTIVS 688  baker's yeast
AAA66476   562 dfISNDLPygYDTLVGQGTGTiagLSGGQRQRIAIARILLKNAPILLMDEATSALDTESEAKVQNALNNAm--kGRTVLI 639  Schistosoma mansoni
Q06034     509 hdTIMALPdrYDTPVGPVGSL---LSGGQKQRIAIARALVKRPPILLLDEATSALDRKSEMEVQAALDQLiqrgGTTVVV 585  Leishmania enrie...
AAA86667   132 hdFIVSLPh-GYELAGPHGCE---LSGGEKQRIAIARALIRRPHLFLLDEATSALDTQTELRIQSKLNEAl--rGRTALI 205  liver fluke
P33310     553 tkFLANFPdgLQTMVGARGAQ---LSGGQKQRIALARAFLLDPAVLILDEATSALDSQSEEIVAKNLQRRve-rGFTTIS 628  baker's yeast
AAH92161   589 hnFITGFAdgYNTVVGERGVT---LSGGQKQRIAIARALVKNPSILILDEATSALDAESERVVQEALDRAt--tGRTVLI 663  zebrafish
AAZ04383  1276 dsFISTFPdgYDTQVGKGGSQ---LSGGQKQRIAIARALLTQPRMLILDEATSALDAESERIVQATLDNViatkERVTLM 1352 Toxoplasma gondii

Feature 1        #                                                                          
P21439     587 IAHRLSTVrnADVIAGFEd------------------------------GVIVEQGSHSELmk--keGVYFKLVNMQ 631  human
P13568     619 IAHRLSTIryANTIFVLSnrersdnnnnnnnddnnnnnnnnnnkinnegSYIIEQGTHDSLmk--nkNGIYHLMINN 693  Plasmodium falcipar...
P13568    1368 IAHRIASIkrSDKIVVFNnpd-------------------------rngTFVQSHGTHDELlsa-qdGIYKKYVKLA 1418 Plasmodium falcipar...
AAA20682   689 IAHRLSTIrrSENVIVLGh-----------------------------dGSVVEMGKFKELyanptsALSQLLNEKA 736  baker's yeast
AAA66476   640 IAHRLSTVrkADLILVMSk------------------------------GQIVEKGTHSELma--nhGYYYNLVQRQ 684  Schistosoma mansoni
Q06034     586 IAHRLATIrdMDRIYYVKhdg-------------------------aegSRITESGTFDELle--ldGEFAAVAKMQ 635  Leishmania enriettii
AAA86667   206 SAHRLTATsgAETVVVLAd------------------------------GHKLESGKPDELiq--lhGAYHALYHAQ 250  liver fluke
P33310     629 IAHRLSTIkhSTRVIVLGk-----------------------------hGSVVETGSFRDLiaipnsELNALLAEQQ 676  baker's yeast
AAH92161   664 IAHRLSTIqaADLICVMSn------------------------------GRIVEAGTHLELls--kgGLYAELIKRQ 708  zebrafish
AAZ04383  1353 IAHRLSTVrdADKIVVLSned-------------------------krgSQVVEVGTHDELmai-pdGVYRHLVKVA 1403 Toxoplasma gondii

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