1WAB,1FXW


Conserved Protein Domain Family
PAF_acetylesterase_like
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cd01820: PAF_acetylesterase_like 
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PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate specificity towards PAF, hydrolyzing an acetyl ester at the sn-2 position. PAF-AH also degrades a family of oxidized PAF-like phospholipids with short sn-2 residues. In addition, PAF and PAF-AH are associated with neural migration and mammalian reproduction.
Links
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Statistics
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PSSM-Id: 238858
Aligned: 19 rows
Threshold Bit Score: 250.284
Created: 30-Oct-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Citation:PMID 8985254
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Structure:1WAB, Bos Taurus PAF-AH binds acetate ion, contacts at 3.5A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                      #                                
1WAB          7 PASKPTPVQDVqg-----dgRWMSLHHRFVADSKDKe--PEVVFIGDSLVQLMHQc---------eIWRELFSPLHALNF 70  cow
YP_200718   284 AATSLIPVDWLeqd----syDWYARHHAALAAARSLk--PEVVMIGDSITHFWSGppqatrvsgpeSWQWLYGKRPVLNL 357 Xanthomonas oryz...
YP_663334     6 KALSITPVARTe-------pWWQERHLQKMDEKKALnddVDLLFLGDSITHSWEDtg-------aaTWKKHYAHLKPLNL 71  Pseudoalteromona...
CAD71852    533 VNTATIPATRGde------pGWQKRNMAMSKLAKTAk--PKLAFIGDSITQGWEGrg-------kkVWEENYAEYDTINL 597 Rhodopirellula b...
ZP_01089007  31 KPAAVTPEPRDa-------qWWTDRHAQKLAAAKAQd-kIDLLMIGDSITHGWENkg-------keVFAEFYADRNPHNI 95  Blastopirellula ...
NP_641897     1 MASAQTPPPSIvptdrlqesWWAQRHAQVLEQVKQHp-dAKLLLIGDSITQNYEKakapd-edfqpTWQTFYGSRGALNL 78  Xanthomonas axon...
XP_309124     3 ATTLPAICKDLdg-----ddRWLSIHKRFVAECKEKd--PDVMFIGDCILESLQFt---------dYWNQHFVPMHCLNF 66  Anopheles gambia...
XP_970187     3 PCVIPKLSEDYdg-----deRKLSMHKRFVQQARTCe--SEILFIGDSIIEQLQFs---------tLWLEKISALHCINF 66  red flour beetle
ZP_01145193  23 LAAVPIGRMDLp--------WWRHRFEHTKQEAREHp-dARLVWLGDSITEYWHRegpnpyqqilpIWRHYYGRYDALNF 93  Acidiphilium cry...
AAW27306      3 STIAVSPPDTEed------gRWMSQHTRFVCQARKKe--PDVVLLGDSIFVYMQFt---------qTYKKHIEPLHCVNF 65  Schistosoma japo...

Feature 1          #                              #                                             
1WAB         71 GIGGDSTQHVLWRLENGELEHIr-PKIVVVWVGTNNHght-------aeQVTGGIKAIVQLVNERQPqARVVVLGLLPRG 142 cow
YP_200718   358 GFGWDRTQNVLWRIRQGELDGLd-PRWVVLHIGTNNLtgtaqsrastpaEAALGVQAVVGEVRRRLPdSKLILMVIMPRG 436 Xanthomonas oryz...
YP_663334    72 GYSGDCTEHLLWRLQNGEIDNLt-PKLTVILIGTNNAghrv----esaqDTAAGVKAILNEVQSRLPkSKILILATFPRS 146 Pseudoalteromona...
CAD71852    598 GIGGDRTEHIIWRLTHGNLGKIq-PEVAVLMIGTNNTghfm----qdptQIAEGVEEILSILREKLPnTKIVLQAIMPRG 672 Rhodopirellula b...
ZP_01089007  96 GFSGDRTEHVLWRFDHGALDNMs-PKLAVLMIGTNNVghrk----dpsqDTADGIQLIVEELREKLPeTKVLILGIFPRS 170 Blastopirellula ...
NP_641897    79 GFSGDGTENVLWRLANGEVDGLq-PKVALVLIGTNNTghlg----qtaeQTQLGIDAVVAAIEQKLPrTHILLLSVLPSD 153 Xanthomonas axon...
XP_309124    67 SIRTDRTQNILWRLQNGELDNVr-PKAIVLHAGTNNIgds-------seEVTEGILELVRTIRQKLPdVYIILPTLLPRG 138 Anopheles gambia...
XP_970187    67 GIGGDRVENVLWRIQNGELDFNvkLKAVVLFVGTNNTdct-------phEIFEGILEIVKEIKQRLGnVFVILPTLLPRG 139 red flour beetle
ZP_01145193  94 GLIGDTTASVIWRIDHGEFAGLh-PRLVVLLIGANNLgrth----wgadQTVPGIEEVVRDLHRHVPgAHVLLLGILPSI 168 Acidiphilium cry...
AAW27306     66 SIANDKTQNVLWRIENGELDGFs-PKVVVIMIGSHNIdds-------eeEVVKGILSVAEKTKSKQPrASLIVMGLLPCG 137 Schistosoma japo...

Feature 1                                                                       #  #            
1WAB        143 qh-pNPLREKNRRVNELVRAALAGhp-------rAHFLDADPGfv-------hSDGTISHHDMYDYLHLSRLGYTPVCRA 207 cow
YP_200718   437 rnadDARRAPIAETNRLLVARYAKdp-------aVRLVDIGPKlv-------qADGTLPEALMPDGTHPSEAGYRIWAHA 502 Xanthomonas oryz...
YP_663334   147 ksknAPMRKRVNAINDLVQHLTDNk--------nTFWLDIGHVfl-------tEDGTVLDTVMPDFLHLTSEQYQVWADA 211 Pseudoalteromona...
CAD71852    673 ktkmDLMRLNNIAVNDRIAKMADGe--------nIVYVDLGDHfl-------nEDGTIDPAIMPDYLHLSEKGYEIWADA 737 Rhodopirellula b...
ZP_01089007 171 anknDEMRKLNDGTNEIIKDLADGe--------nVFFLNINDTfl-------tEDGVLSKEVMPDLLHPHAKGYRMWAEA 235 Blastopirellula ...
NP_641897   154 l--sSEKSRRDAQINQGLAVRYGDnp-------rVTYLDVSSVf--------qRDGKLRTELFYDTRFRPAAGALHPDTR 216 Xanthomonas axon...
XP_309124   139 qq-pNELRDKNDQVNRLLRERCIGin-------kVQIVTVDSGli-------qSDGTISHHDMFDYLNLTNVGCKKVFEP 203 Anopheles gambia...
XP_970187   140 qy-pNPYRERNEHVNTFLIDKFCNeanadehtqnVHVVEIHHNiv-------qNDQTISHHIMHDYLHLTNSGYLKVFGP 211 red flour beetle
ZP_01145193 169 r--sAWISAQTRIINADLARRYAGsr-------lVTFRNVGHVlevdgradpaLYVDPRMHPPEPALHPDAEGMRRIAAA 239 Acidiphilium cry...
AAW27306    138 rt-pNKRRKKHEEINKLLTKSFFCrp-------dVTYLNPDWDsf------vqQDGTISHRDMFDYMHPTENGYEKLCDP 203 Schistosoma japo...

Feature 1                
1WAB        208 LHSLLLRLL 216 cow
YP_200718   503 LREAGITAA 511 Xanthomonas oryzae pv. oryzae KACC10331
YP_663334   212 MQNTIARLM 220 Pseudoalteromonas atlantica T6c
CAD71852    738 LAPTLESLG 746 Rhodopirellula baltica SH 1
ZP_01089007 236 VEPTIAKLM 244 Blastopirellula marina DSM 3645
NP_641897   217 GQRMLAEAI 225 Xanthomonas axonopodis pv. citri str. 306
XP_309124   204 VCDLLHQIL 212 Anopheles gambiae str. PEST
XP_970187   212 VYDKLCTLL 220 red flour beetle
ZP_01145193 240 LQPTITRLM 248 Acidiphilium cryptum JF-5
AAW27306    204 LLEELQNSL 212 Schistosoma japonicum

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