2C9W


Conserved Protein Domain Family
SOCS
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cd03587: SOCS 
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SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.
Links
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Statistics
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PSSM-Id: 239641
Aligned: 155 rows
Threshold Bit Score: 39.7609
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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elongin B/C
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:elongin B/C interaction
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1      ######     #       #     #             
2C9W_A     130 SAPSLQHLCRLTINKC---TGAIWGLPLPtrLKDYLEEY 165  human
XP_698923  702 NVKSLQHLCRFCIRQLv-rIDHIQELPLPkpLIVYLRKF 739  zebrafish
XP_612207  574 NVKSLQHLCRFRIRQLv-rIDHIPDLPLPkpLISYIRKF 611  cattle
NP_055413  514 NVKSLQHLCRFRIRQLv-rIDHIPDLPLPkpLISYIRKF 551  human
AAW25386    44 VVASLRHLSRFTILSYi-rRDHIDQLPLPrtIINYLMEK 81   Schistosoma japonicum
EAA12058    14 HVQSLQHICRFVIHKTikrKDLIQALPLPrrVLDYLCYK 52   Anopheles gambiae str. PEST
XP_780887  352 EVKSLQYLCRFVIRETy-pRHHIRHLPLPkkINEYILEN 389  purple urchin
NP_523390  979 HVQSLQHMCRFVILKAvirKDLIQTLPLPrrLLDYLNYK 1017 fruit fly
XP_973720  590 QVQSLQHICRFAIHKVv-rRDLIPSLPLPrrMIDYLNTP 627  red flour beetle
XP_968194  257 EVRSLKHLCKFVIRQYt-nMNDIPKLPLPtvLHGYLLEK 294  red flour beetle

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