Conserved Protein Domain Family
SLC6sbd_CT1
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cd11509: SLC6sbd_CT1 
Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain
CT1 (also called CRTR, CRT) transports creatine. Human CT1 is encoded by the SLC6A8 gene. CT1 is ubiquitously expressed, with highest levels found in skeletal muscle and kidney. Creatine is absorbed from food or synthesized from arginine and plays an important role in energy metabolism. Deficiency in human CT1 leads to X-linked cerebral creatine transporter deficiency. In males, this disorder is characterized by language and speech delays, autistic-like behavior, seizures in about 50% of cases, and can also involve midfacial hypoplasia, and short stature. In females, it is characterized by mild cognitive impairment with behavior and learning problems. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Links
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Statistics
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PSSM-Id: 271397
Aligned: 6 rows
Threshold Bit Score: 1012.46
Created: 18-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
XP_695932  64 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLFIFLGGIPIFFLEIALGQFMKaGSINVWNIAPLFK 143 zebrafish
P48029     52 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKaGSINVWNICPLFK 131 human
CAF95116   61 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYLLFVFIGGIPVFFLEIALGQFMKqGGVSAWNIAPLFK 140 Tetraodon nigrovir...
P31661     52 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKaGSINVWNICPLFK 131 rabbit
AAI53346   38 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYLLIVFVGGIPVFFLEIALGQFMKqGGIAAWNIAPLFK 117 western clawed frog
Q91502     36 RVTWSRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYLLVAVFGGIPIFFLEISLGQFMKaGGINAWNIAPLFK 115 marbled electric ray

Feature 1                                                                                     
XP_695932 144 GLGYASMVIVFFCNTYYIMVLAWGFYYFIKSFNATLPWSTCDNPWNTENCIEIFRQgdckngt----------------- 206 zebrafish
P48029    132 GLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHedcan------------------- 192 human
CAF95116  141 GLGLASMVIVFFCNTYYIMILVWGLYFLFHSFTNPLPWATCGHPWNTQNCTQDFRRachnrsaalswsavtpssllssts 220 Tetraodon nigrovir...
P31661    132 GLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHedcan------------------- 192 rabbit
AAI53346  118 GLGFASMVIVFFCNTYYIMILVWGLYYLVHSFTNTLPWATCGNPWNSKECTEVFLVdhcnngsla--------------- 182 western clawed frog
Q91502    116 GLGYASMVIVFFCNTYYILVLTWSSFYLVQSFSSPLPWASCNNTWNTAACYEAGANast--------------------- 174 marbled electric ray

Feature 1                                                                                     
XP_695932 207 ----ignstfgNLTCeelanGRSPIIEFWENKVLNISDGLDEPGAVNWELMLCLLAVWVMVYFCVWKGVKSTGKIVYFTA 282 zebrafish
P48029    193 -------aslaNLTCdqladRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTA 265 human
CAF95116  221 lvnlssaqsflNSSCtetegLRSPVIEFWERKVLRLSGGLHELGNISYEMVLCLIATWIIVYFCMWKGVKSTGKVVYFTA 300 Tetraodon nigrovir...
P31661    193 -------gslaNLTCdqlaeRRSPVIEFWENKVLRLSGGLEVPGALNSEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTA 265 rabbit
AAI53346  183 --nvtdsgtlvNISCdalvnKRSPVIEFWERKVLQISGGLNEPGQLNWQMILCLMATWVIVYFCIWKGVKSTGKVVYFTA 260 western clawed frog
Q91502    175 --------eiyPPTAp----AQSSIVQFWERRVLRLSSGLGDVGEIGWELTLCLTATWMLVYFCIWKGVKTSGKVVYVTA 242 marbled electric ray

Feature 1                                                                                     
XP_695932 283 TFPYVVLIILLVRGVTLPGAYDGILYYVKPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNDCYKDAFVLA 362 zebrafish
P48029    266 TFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILA 345 human
CAF95116  301 LFPYVILVVLLAHGATLPGALDGIIYYLKPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFHNNCYRDAFILA 380 Tetraodon nigrovir...
P31661    266 TFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLRSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILA 345 rabbit
AAI53346  261 LFPYVVLIVLLAHGVTLPGALDGIVYYLKPNWSKLAEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFHNNCYRDAYILA 340 western clawed frog
Q91502    243 TFPYIILVILLVRGVTLHGAVQGIVYYLQPDWGKLGEAQVWIDAGTQIFFSYAIGLGTLTALGSYNQLHNDCYKDAFILS 322 marbled electric ray

Feature 1                                                                                     
XP_695932 363 LINSGTSFFAGFVVFSILGFMASEQGVDISKVAESGPGLAFIAYPKAVSMMPVAPVWAALFFIMLLLLGLDSQFVGVEGF 442 zebrafish
P48029    346 LINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGF 425 human
CAF95116  381 IINSGTSFFAGFVVFSVLGFMATEQGVDISKVAESGPGLAFIAYPKAVTLMPLAPLWAALFFFMLLTLGLDSQFVGVEGL 460 Tetraodon nigrovir...
P31661    346 LINSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGF 425 rabbit
AAI53346  341 AINSTTSFFAGFVVFSVLGFMASEQGVHISKVAESGPGLAFIAYPKAVTLMPFAPIWAALFFFMLLILGLDSQFVGVEGF 420 western clawed frog
Q91502    323 LVNSATSFFAGLVVFSILGFMAVEEGVDISVVAESGPGLAFIAYPKAVTLMPFPQVWAVLFFIMLLCLGLGSQFVGVEGF 402 marbled electric ray

Feature 1                                                                                     
XP_695932 443 VTGILDLFPgky-ymrYQREIAVAICCLLCFIIDLSMVTQGGMYVFQLFDYYSASGMTLLWQAFWECVVVAWVYGADRFM 521 zebrafish
P48029    426 ITGLLDLLPasy-yfrFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFM 504 human
CAF95116  461 ITGIMDMLPpksvlgsLRREVVAAICCIICFLIDISMVTEGGMYVFQLFDYYSASGITLLWQAFWECVVIAWVYGADRFM 540 Tetraodon nigrovir...
P31661    426 ITGLLDLLPasy-yfrFQREISVALCCALCFVIDLSMVQMAGMYVFQLFDYYSASGTTLLWQAFWECVAVAWVYGADRFM 504 rabbit
AAI53346  421 ITGIMDLFPqpi-ngfVRREVTAALCCLVCFIIDLSMVTEGGMYVFQLFDYYSASGITLLWQAFWECVVIAWVYGADRFM 499 western clawed frog
Q91502    403 VTAILDLWPskf-sfrYLREVVVAMVICLSFLIDLSMITEGGMYIFQIFDYYSASGTTLLWTAFWECVAVAWVYGGDRYL 481 marbled electric ray

Feature 1                                                #                                    
XP_695932 522 DDIARMIGYRPFPWMKWCWSIITPCVCMGIFLFHLLNYKPLTYNNVYVYPWWGEVIGWCLALSSMLCIPVSLVYKLSGAK 601 zebrafish
P48029    505 DDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAK 584 human
CAF95116  541 DDVARMIGYHPLPYMKCCWSYITPLVCVGVFLFHVVNFKPLTYNTVYTYPWWGEMLGWGLALSSMLCIPLTVLYKLLRSN 620 Tetraodon nigrovir...
P31661    505 DDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNIVYYKPLVYNKTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAK 584 rabbit
AAI53346  500 DDIARMIGYRPLPYMKWCWSVLTPLVCVGIFVFHVVNYKPLTYNKSYVYPWWGEAIGWSLALASMLCIPLTVVCKMLRSK 579 western clawed frog
Q91502    482 DDLAWMLGYRPWALVKWCWSVITPLVCMGIFTFHLVNYKPLTYNKTYTYPWWGEAIGWCLALASMLCVPTTVLYSLSRGR 561 marbled electric ray

Feature 1                                                         
XP_695932 602 GtFKERWENLTKPVWGAHHLEYmapdtd-ikslasLSPGMEENKVIIFESVM 652 zebrafish
P48029    585 GtMAERWQHLTQPIWGLHHLEYraqdad-vrglttLTPVSESSKVVVVESVM 635 human
CAF95116  621 GsFRERWKKLTTPVWGRHHLEYftpe-----teakLLPSAEAKNTLQFESVI 667 Tetraodon nigroviridis
P31661    585 GtMAERWQHLTQPVWGLHHLEYraqdad-vrglttLTPVSESSKVVVVESVM 635 rabbit
AAI53346  580 GsLRERWHLLTTPVWGHHHLEYltpeaetkllppdTLVTANKEKATLFETVI 631 western clawed frog
Q91502    562 GsLKERWRKLTTPVWASHHLAYkmagak--inqpcEGVVSCEEKVVIFESVL 611 marbled electric ray

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