Conserved Protein Domain Family
TMC
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pfam07810: TMC (this model, PSSM-Id:285101 is obsolete and has been replaced by 462275)
TMC domain
These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 and EVIN2 - this region is termed the TMC domain. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters.
Links
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Statistics
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PSSM-Id: 285101
Aligned: 115 rows
Threshold Bit Score: 72.8876
Created: 25-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q54BH1       435 VGSQFLFILVLDLTLSnlweIIySVSMAYIGRRRe-------kSGKKSTesyKPEFEISEEYLEILYRQFIVYLGLPIYP 507 Dictyostelium d...
XP_005458568 444 FGREMYKLSIFNFLAT----FF-SVFFFNYPRKLvqetyprslLARISG---KQRFLIPFNVLDLVYSQTVSWVGVYYCP 515 Nile tilapia
XP_007246163 438 FGKEMYKLTIFHLLAC----FC-NAFLVSFPRAWivdkypssmLAKKIG---KPEFVIPLNILDLVYSQTVTWVGVFYCP 509 Mexican tetra
XP_008102414 455 IGQEMYKMTIFSFLTT----LA-SAFLISLPRRLlakh-sssaLAQWLG---KEEFLVPHNVLDIVAGQTVIWIGIFFCP 525 green anole
CAG06020     229 LGKEMYKLSIFNFLAT----IC-NAFLFNFPRKFlqeacpsslLARLSG---QQRFLIPFNVLDLVYGQTVSWMGVYYCP 300 spotted green p...
XP_009304608 451 FGKEMYKLTIFNLLEG----FF-SAFCVAYPRTFlvekfpssrLAQILG---NNQFEITLNVLDLVNSQTVMWVGVFYCP 522 zebrafish
XP_005810422 447 IGIQMYNLCIFNFLTT----FC-NTFLVNYPRKLlqekhptcfLVRLCG---RQRFLIPFKVLDLVYIQTVLWVGVYYCP 518 southern platyfish
XP_006635471 437 IGQEMYKLLVFDFLAS----LG-NTILVAYPRKQlver-cswrLVQMIG---KDQFLIPLNVLDIVYSQTVSWVGLFFCP 507 spotted gar
XP_010743308 443 FGREMYKLCIFNFLAT----FC-NAFLLNYPRKLvqekfptslLARVLG---KQRFLIPFNVLDLVYSQTVSWVGVYYCP 514 large yellow cr...
XP_002932568 129 MGQEFYKLFIFHFLKM----LM-EFLLLQLPLRLmasc-cqcwLISWLN---QEQFQLPQNVLDTVYGQTLVWGGLFYVP 199 western clawed ...

Q54BH1       508 IVTLFGVVCNIVEYYVDRFRLIRICKKPHRM 538 Dictyostelium discoideum AX4
XP_005458568 516 LLPVIGIVSLVVTFYVKKFSVMRCCVPEQRM 546 Nile tilapia
XP_007246163 510 LLPAISIVKLLVIFYMKMFTVIRCCAPAQRM 540 Mexican tetra
XP_008102414 526 LLPLLGCVSIFLTFYVKKYTLFQNCQPSTQL 556 green anole
CAG06020     301 LLPLIGTVTLIVTFYIKKVTVLWCCRPEQRM 331 spotted green pufferfish
XP_009304608 523 LLPAISTLRLLILYYIKKFTVMRCCAPAQRM 553 zebrafish
XP_005810422 519 LLPMIGVVSLLVIFYIQKFDVLQCCEAEQRM 549 southern platyfish
XP_006635471 508 LLPLLNLVKMLALFYIRKFHLFRNCAPVRRM 538 spotted gar
XP_010743308 515 LLPLIGTVTLIATFYIQKFVVMRCCVAEQRM 545 large yellow croaker
XP_002932568 200 LLSLLNIIFIFITFYVKKYYLYHLCDSPRKL 230 western clawed frog
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