Conserved Protein Domain Family
VWA_N
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pfam08399: VWA_N (this model, PSSM-Id:285584 is obsolete and has been replaced by 462464)
VWA N-terminal
This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, pfam00092) and Cache (pfam02743) domains. It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits.
Links
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Statistics
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PSSM-Id: 285584
Aligned: 49 rows
Threshold Bit Score: 105.417
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7PM11         10 SESDPESATSKAHPS----AFYDARR-----In----eYQSDGRLAEgs------rQ---MLLRHMRRFEgYPVNISLSS 67   Anopheles gam...
XP_009198965  144 AENFQKAHRWQDNIKeediVYYDAKA-----Dae---lDDPESEDVErgsk-astlR---LDFIEDPNFKn-KVNYSYTA 210  olive baboon
XP_011605244  102 AEDFQKEYVWKDEFEddeiAYYNSK------Dn----lDANETEGRKyr------mR---PDFKEDPTFK-RLTDYNHTA 161  torafugu
CDS28666       51 knSIEEEFKLQESLdh-deCYIRAKA-----VslfphlPDENGTVITpc------nEsqfLPLESDPMFGnFYISRNMSA 118  Hymenolepis m...
KFV20671        3 AKKIREKFNRYLDVVnrnkQVVEASYtahltSp----lTAIQDCCTIpp------sM---MEF--DGNFn-TNVSRTISC 66   red-crested t...
XP_005453547  111 AEQLQKEHVWQDGVTenaiSYYDSKA-----Ds-----DYTEDGEEEnpletssslE---LEFVDDPNFK-NKVNYSSSA 176  Nile tilapia
NP_001013521   71 AEDIQREHSWQDAIKendiQYYDAKA-----Ds-----DVMDDDDGEnlldnpnslS---LEFVDDPNFK-NKVNYSYTA 136  zebrafish
XP_007234505  111 AERVQKAHRWQDSIKewdiEYYDSKA-----El-----DYDGDEFeaq-----mslK---LEFVYDPNFK-NNVNYSYTA 171  Mexican tetra
XP_005052994   72 AEKFQKAHHWQDSIReediEYYDSKA-----Dt-----EYDDPDGEEiereksnslK---LEFTDDDNFK-TKVNYSYAA 137  collared flyc...
XP_006633315  121 AENFQMEHGWKHEFAdddiVYYNAKD-----Dly---sDTNKTDGRRr-------iK---PDFKEDPAFK-RRISYNHSA 181  spotted gar

Q7PM11         68 VLLPAGVSLD-DPET-QSAIKWSSHLDPLFANNIERDSALSWQYFGSSTGFLRRFPGTAW 125  Anopheles gambiae str. PEST
XP_009198965  211 VQIPTDIYKG-STVI-LNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPW 268  olive baboon
XP_011605244  162 VHIPTDIYDG-STIV-LNELNWTEALEEVFKKNREEDPTLLWQVFGSATGLARYYPASPW 219  torafugu
CDS28666      119 AHVPTNVYDL-SKEI-RTVGNLTHHLDEVFKKNLKEDPLLKWQYFCSSTGFLKFYPGAMW 176  Hymenolepis microstoma
KFV20671       67 --------DRlSTTVnSRAFNPGRDLNSVLADNLKSNPGIKWQYFSSEEGIFTVFPAHKF 118  red-crested turaco
XP_005453547  177 VQIPTDIYKG-SPVI-LNELNWTQALERVFIENRREDSSLRWQVFGSATGMTRYYPATPW 234  Nile tilapia
NP_001013521  137 VQIPTDIYKG-SPTI-LNELNWTQSLERVFIENSREDPSLRWQVFGSTTGVTRYYPATKW 194  zebrafish
XP_007234505  172 VQIPTDIYKG-APVI-LNELNWTQALERVFMENSREDPSLLWQAFGSATGVTRYYPATPW 229  Mexican tetra
XP_005052994  138 VQIPTDIYKG-STVI-LNELNWTQALEDVFIENRKEDPSLLWQVFGSATGVTRYYPATPW 195  collared flycatcher
XP_006633315  182 VHIPTDIYEG-STVV-LNELSWTEALENIFKKNREEDPTLLWQVFGSATGLARYYPASPW 239  spotted gar
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