Conserved Protein Domain Family
STN1_2
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pfam09170: STN1_2 (this model, PSSM-Id:286279 is obsolete and has been replaced by 462701)
CST, Suppressor of cdc thirteen homolog, complex subunit STN1
STN1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required for protecting telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity on their own. In addition to telomere protection, the CST complex probably has a more general role in DNA metabolizm at non-telomeric sites.
Links
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Statistics
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PSSM-Id: 286279
Aligned: 22 rows
Threshold Bit Score: 209.855
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9H668       157 DPVWNIQIARMLELPTIYRKVYDQPFHSSALEKEEALSNPGAlD---LPSLTSLLS---E---K---AKEFLMENRVQSF 224 human
B8JKF4       164 DPAMAVQISRMLELPQLYRKCYDQPFKMPSD--DLGSTEAGGs-----SHPQYLLS---RavlT---LKEFLLEKEVTRF 230 zebrafish
XP_006630888 362 DPVLAVQISRMMEVPQLYRRFYDKPFQVPHGLQERSSDCDLE-G---VTSLPSLLG---QvclS---LKDFLRKEAVQSF 431 spotted gar
XP_007251425 160 DPVMDVQIARMLEIPQLYRDCYDKPFQALGSEVEASTTDAGG-H----PNFQSLLG---QsvrI---LKKFLKEKEVAKF 228 Mexican tetra
XP_011610873 164 DPMMAVQIEWMMEVPELYRQCYDKPFKL--------HPDASG------EPAMSTLS---KatnI---IRDFLKQKSVVRF 223 torafugu
XP_003218541 159 DPAYEVQIARLLELPRLYRDIYDKPFQIPEETKSQGV----A-S---LFGSVSVLS---E---K---IRAFLLRNKIQSF 221 green anole
XP_005995880 161 DPVWAVQISWMLELIHLYRNVYDQPFKLSEHLKERAHALKSE-GmvtFPVLVAALA---D---K---IRQFVLENHVQTF 230 coelacanth
XP_005470224 139 DPVMAVQISWMMEAPQLYRQCYDKAPQLE----------PDA-A---GDSAVSSLSratK---I---LKDFLKQKSVSRF 198 Nile tilapia
XP_005797716 156 DPVMAVQIAWMMEVPQLYRLFYDKRFQL------------DV-A---GDSAETSLS---K---AtnvIKDFLKQRLVAKF 213 southern platyfish
CAG06173     172 DPMMAVQIEWMMEVPELYRQCYDKPFEV----------QPDA-S---GEPAVSALS---KaanI---IKEFLIQKSVVRF 231 spotted green p...

Q9H668       225 YQQELEMVESLLSLANQPVIHSASSDQVNFKKDTTSKAIHSIFKNAiQLLQEKGLVFQKDDGFDNLYYVTREDKDLHRKI 304 human
B8JKF4       231 RPYDVEFL--LHPLIQR----SSAEQEADQPGTSFATQVGKLLKETlSFLQDEGQIFRKKRTQDEVYNVTEQDKDLHIAI 304 zebrafish
XP_006630888 432 HPNDLETVNSLVSLASHDLQNGPDQQQAARSL-STSKQIHSVFREAiQVLQEEGLLFRKAGSQEEVYQVTEQDKELHRVT 510 spotted gar
XP_007251425 229 RPYDVEYL--LHPLIQWPPRNTASGQEVTSAGPSFSTQVKNLLKETlKILQSEGEIFRKVLSPDELYNVTEQDKDLLAAI 306 Mexican tetra
XP_011610873 224 RPYDVLDL--LHPLVPEQPRTDSAGE--PVAGPSACQQARQLLKEAlQILQDEGIVYRKLKSQDEVYQVTIHDKDLLIAI 299 torafugu
XP_003218541 222 YKQDLETVEEFVDLIRQ----GTAAEQTDSKPHSFSSLIRESFLEAiRILENKGVLFQKSKNPNDMYYVTEQDRELHRVT 297 green anole
XP_005995880 231 SVKDLETVKSLVCFANRPVQSPSPAEEA-SKVVSTSKQVRGAFNEAiQLLMNAGSIFQKKSSSED-YVVTSENKELRTLT 308 coelacanth
XP_005470224 199 RPYDVQDL--LQPLISSQPQAASADQE-PVAGPSACQQLRQLLKEAlQILQDEGAVYRKVKSQDEVYLVTVQDKDLLVAV 275 Nile tilapia
XP_005797716 214 RPYDVQDL--LQPLISSRLQ-----AQEAVAGPSGCQQLNQLLKEVlQVLQDEGTVYRKVKSQDEVYHVTIQDKDLLIAV 286 southern platyfish
CAG06173     232 RPYDVLDL--LEPLVPRQPRTESADQ--PMAGPSACQQLRQLQKEAlKVLQDDGVVYCKFKTQDEVYHVTVQDKDLIIAI 307 spotted green p...

Q9H668       305 HRIIQQDCQKPNHMEKGCHFLHILACARLS 334 human
B8JKF4       305 KDVLREDTKREKYAEKGCHVLHILSSVRQR 334 zebrafish
XP_006630888 511 KEIICEDSRREKYAEKGCHFLHILSCVRQS 540 spotted gar
XP_007251425 307 RDMIREDSKREKYAEKGCHVLHILSSVRQK 336 Mexican tetra
XP_011610873 300 KDIIREDCRREKYAEKGCHLLHILSAVRQR 329 torafugu
XP_003218541 298 LKVLKEDCKRPKYAEKGCHLRHIHNCVNQN 327 green anole
XP_005995880 309 LDTVREDCRKWRHAEKGCSFSYILKCIQHS 338 coelacanth
XP_005470224 276 KDIIREDSRREKYVEKGCHVLHILSAVRQR 305 Nile tilapia
XP_005797716 287 KDIIREDSKREKYAEKGCHILHILSAVRQR 316 southern platyfish
CAG06173     308 KDIIREDSKKEKvkmqfrtvldvkvvdvek 337 spotted green pufferfish
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