Conserved Protein Domain Family
RICTOR_phospho
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pfam14665: RICTOR_phospho (this model, PSSM-Id:291337 is obsolete and has been replaced by 464247)
Rapamycin-insensitive companion of mTOR, phosphorylation-site
Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient- and growth-factor signalling. This short region is the phoshorylation site. Rictor does interact with 14-3-3 in a Thr1135-dependent manner. Rictor can be inhibited by short-term rapamycin treatment showing that Thr1135 is an mTORC1-regulated site.
Links
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Statistics
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PSSM-Id: 291337
Aligned: 10 rows
Threshold Bit Score: 163.106
Created: 17-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007250135  986 PFTILASSRFVRNRFL--ISLSSKKLRSTSDPKGSgggsgsssK-HNS-DLKlG-----GLRRNRTVTEP-S-V-YSPGQ 1053 Mexican tetra
XP_006000410 1030 PFTILASTRFMRNRFInsLTLPGKKLRSSSDPKGG--------K-PSS-DDK-L-----GLRRNRTVTEPsS-S-TDYVP 1091 coelacanth
XP_006627349 1087 rLTILASSRFVRNRFInsLTLPSKKLRSSSDPKGG--------K-TPT-EPK-P-----GLRRNRTVTEP-S----SYSQ 1145 spotted gar
ETE70696     1060 PFPFFSSRRLVRNRILnsLTLPNKKLRSSSDPKGG--------K-LSSlENK-M-----GLRRNRTVTEPcS-S-MDFTR 1122 king cobra
XP_008114293 1093 PFPFFSSGRLAKNRFLnsLTLPNKKHRSSSIPKSG--------KlSSS-ESK-M-----GLRRNRTVTEP-SgS-IDFTR 1155 green anole
XP_004937264 1085 PFPFFSSSRIVKNRILnsLTLPNKKHRSSSDPKGG--------KlTSS-DSK-S-----SLRRNRTVTEP-S---LDFPS 1145 chicken
XP_007665700 1031 PF-FFAPSRLVKNRILnsLTLPNKKHRSSSDPKGG--------K-HSS-ESK-S-----SARRNRTVTEP-S-SgTDFNH 1091 platypus
XP_009238939  902 SFPFFASSKLVKNRILnsLTLPNKKHRSSSDPKGG--------K-LSS-ESK-T-----SNRRIRTLTEP-S---VDFNH 961  Sumatran oran...
XP_005161298 1093 PFTILASSRLVRNRFL--ISLSGKKLRSTSDPKGT--------G-SSS-KLQ-GeltlgGLRRVRTVTEP-S-I-FSSSQ 1156 zebrafish
XP_009299472 1075 PFTILTPSHL-RNRFLnsLSLPSKKGRSPTDTKG-----------TSF-TAK-TpdelrLMHCNRSIAEV-A-N-SSPGH 1137 zebrafish

XP_007250135 1054 GDVFSPVFADGHLPKSPSVSLETSFVGSKTAEHQGSTPSITEGEVRVPRA 1103 Mexican tetra
XP_006000410 1092 GDMFTPFFNGNRVPKSHTMSLETSFVGSKHTEDRGSTPSIGENDLKLPKG 1141 coelacanth
XP_006627349 1146 GDVFTPVFNGNRFSKSPTVSLETSFVGSKASEDQGSTPSIGEPELKLPRv 1195 spotted gar
ETE70696     1123 GDDFTPVF---KVPKIHTLKLETSFVGSKHSEDADSTPSIGENDLKLPKS 1169 king cobra
XP_008114293 1156 GDDFTPIF---RVPKIQTFKLETSFVGSRQNEDAASTPSLGENDLKLPKN 1202 green anole
XP_004937264 1146 GEEFNPVF---RVPKIQTLPTETSMCLLPTKEDTDSTPSIGENDLKLPKG 1192 chicken
XP_007665700 1092 SDEFIPI---SRVQK--KLGLETSFVGSRHTEDTGSTPSIGENDLKFTRS 1136 platypus
XP_009238939  962 SDDFTPIST---VQK--TLQLETSFMGNKHIEDTGSTPSIGENDLKFTRN 1006 Sumatran orangutan
XP_005161298 1157 GDVFSPVFTDGHLPKSPSVSLETSFVGTKTLDTQDSTSSIGEQEVRLNRT 1206 zebrafish
XP_009299472 1138 SEVF---YNGSRMPRSPTVSLETSFVGIKALAEPYATDSESRNQFKRERN 1184 zebrafish
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