Conserved Protein Domain Family
THRAP3_BCLAF1
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pfam15440: THRAP3_BCLAF1 (this model, PSSM-Id:292080 is obsolete and has been replaced by 464718)
THRAP3/BCLAF1 family
This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1).
Links
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Statistics
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PSSM-Id: 292080
Aligned: 31 rows
Threshold Bit Score: 246.561
Created: 1-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A2AJT9         9 PrwKHRSLSPvPRNAEHYKQRHSHGHYGCEY---RKDPKr---PVAWRMDSEKHGQSKPRI---------PSRGN--Iy- 70   human
XP_003362423 113 rspkrrsvssqrsrsksrrsyrssrsprssssrssspyskspvsKRRGSQEKQTKTAEGEP---------QEESP--Lk- 180  horse
XP_007484673  97 rrsvssqrsrsrsrrsYRSSRSPRSSSSRSSspySKSPVs---SKRRGSLEKQTKKPEGAP---------PEDSP--Lk- 161  gray short-tai...
XP_003223334 114 spkrrsrssqrsrsrsrrsyrssrsprssssrssspyskspvssKRRGSSEKQAKKTEAAT---------LQESP--Lk- 181  green anole
XP_012818159 107 rspkrrsassprsrsrsghsyksspsprssssrssskhskspviKIHTTQDKPGQKTEDYN---------KSESP--A-- 173  western clawed...
XP_006631434 157 rsssgrsrrtrgssssdsrsssthsrsgsskrnaakelkesgrPDSAAKEAQRAGSRDEEAagaaggegaPDRAS--Gs- 233  spotted gar
XP_006007786 116 rrsvssprsrsrshhsdrssvsrgssssrssscysqsPVp---SKLRSSLEKQPKKTEGVL---------SEDKA--Sg- 180  coelacanth
XP_006625948 119 krrstsqrsrskshhsarssasrrssssrssslysrsPAp---AKSRGSQDKASKKSEGGK---------EEGSGrqLe- 185  spotted gar
XP_011483948 110 Q--QNRSGSP-PQGQSHRTDRSFSPLSRHSHhssSSTHSsppkARQATGLASQTSEDVKDG---------ELTSK--Qv- 174  Japanese medaka
XP_009290793 112 pksrshsrrsdrsssgrspqshhssssnsgsakrncknVr---EDVLVIEETQGGGDKALV---------EQVKG--Tsa 177  zebrafish

A2AJT9        71 -------------YQSYEHRS--------------------------P-------------------------------- 79   human
XP_003362423 181 -------------SKSQEEPK--------------------------D-------------------------------- 189  horse
XP_007484673 162 -------------NKSQDEQK--------------------------D-------------------------------- 170  gray short-tai...
XP_003223334 182 -------------NKSQEEEK----------------------------------------------------------- 189  green anole
XP_012818159 174 -------------NKSCDEQK--------------------------D-------------------------------- 182  western clawed...
XP_006631434 234 -------------WQGLIDYD--------------------------T-------------------------------- 242  spotted gar
XP_006007786 181 -------------SRQQEEKK--------------------------Dlgkfepdqsklhdefskvstlggdswpglsay 221  coelacanth
XP_006625948 186 -------------EEKGDGKA--------------------------E-------------------------------- 194  spotted gar
XP_011483948 175 -------------QKGGEEDEepeehvelleenptegagsgksdgnwQ-------------------------------- 209  Japanese medaka
XP_009290793 178 aegnvdvdrtlenCQVLMNHD--------------------------S-------------------------------- 199  zebrafish

A2AJT9        80 ---SPNiRNSLE----------------------N----VYMYKPH-------------------------RGYS----- 100  human
XP_003362423 190 ---T-FeHDPSE----------------------S----IDEFNKS-------------------------SATSgdiwp 214  horse
XP_007484673 171 ---T-FeHDPSE----------------------P----IDDFNKSsaasgdiwpglsaydnsprsphspsPVAT----- 215  gray short-tai...
XP_003223334 190 ---SAFeHDPSE----------------------P----LDDFNKS-------------------------AAASgdiwp 215  green anole
XP_012818159 183 ---AFDpSEPLDelgkeldlhgdtwaglsaydnsP----RSPCSPS-------------------------PVTS----- 225  western clawed...
XP_006631434 243 ---SPKrTSPAV----------------------RsaiiVSQGTAH-------------------------PSPS----- 267  spotted gar
XP_006007786 222 ndnSPRsHQS----------------------------------PS-------------------------PVPT----- 237  coelacanth
XP_006625948 195 ---QPAiATSAK----------------------S----DLKRTPA-------------------------VITE----- 215  spotted gar
XP_011483948 210 ---SPKkNS-LG----------------------P----SSVGQKS-------------------------PSPG----- 229  Japanese medaka
XP_009290793 200 ---SPKrTSPQV----------------------C----VSVtnd----------------------------------- 215  zebrafish

A2AJT9       101 --------------------PGrgdsnrraqymP--------------------------KYSEG-Ipykeh-------e 126  human
XP_003362423 215 glsaydnsprsphspspiatPPsqssscsdapmL--------------------------STVHSaKntpsqh-----sh 263  horse
XP_007484673 216 --------------------PPsqssscsdapmL--------------------------STAHSaKntpsqh-----sh 244  gray short-tai...
XP_003223334 216 glsaydn-sprsphspsiasPPsqssscsdahlL--------------------------STVHSaKdtpqhs------h 262  green anole
XP_012818159 226 --------------------PPshssshsacpvM--------------------------NVVRCaKdtlsen-----ih 254  western clawed...
XP_006631434 268 --------------------LQsvavk------------------------------rpspaVKGgSpspsr-------s 290  spotted gar
XP_006007786 238 --------------------PTshsssrsdvalQ--------------------------SIAHSaSgsskigaptqrsh 271  coelacanth
XP_006625948 216 --------------------SWigisayndtspHrspspiptppsqsssrsdtaahqvasKISPPsLpalrl-------h 268  spotted gar
XP_011483948 230 --------------------QTintkisndtsnG--------------------------APV----------------- 246  Japanese medaka
XP_009290793 216 ------------------------------qpiD--------------------------STSSKtSpaqk--------- 230  zebrafish

A2AJT9       127 rnsyPQKV--QGGHspdDHRV--RGSGKGGKPP-----Q-----Rsiadsfrfegkwhedelrhqriqeekysqstrrgs 192  human
XP_003362423 264 siqhSPER--SGSGs--VGNGssRYSPSQNSPI-----HhipsrRspaktitpqnaprdeargrssf-------ypdggd 327  horse
XP_007484673 245 siqhSPERsgSGSLg--NGSS--RYSPSQNSPI-----HhipsrRspaktippqnvpreetrirsf--------ypdggd 307  gray short-tai...
XP_003223334 263 siqhSPER--SGSGs--LGNGssRYSPSQNSPL-----HhipsrRspakavasqnatreetrvrsf--------ypeage 325  green anole
XP_012818159 255 sivhSPEI--SGSGg--NGLK--RYSPSQNSPLqm-stC-----Kspaksvliqnpleeshyhysf---------yadtt 313  western clawed...
XP_006631434 291 saaaQSKS--LGNAp--WQSS--GPAPTSKSPP-----Q-----Qsptavfsgfgffskddvr---------------ag 339  spotted gar
XP_006007786 272 siqrSPER--AGSNt-----S--RYSPSQDSPL-----HhmssrKspvksvtgqslsreeargrssf-------ysdtee 330  coelacanth
XP_006625948 269 slqhSPD----------DPLG--HYSPSHDSPPyqtspR-----Rspakafstvqssrgffpn--------------sde 317  spotted gar
XP_011483948 247 -----------------WQSS--GGTCSTRKPS-----R-----Eglnpmlssfdffsteef----------------qd 281  Japanese medaka
XP_009290793 231 -ssnSPKK--GATA---WQNV--ETAPSNSSPV-----K-----Kstppvfngfglftnldq----------------es 276  zebrafish

A2AJT9       193 edfetrssfqkrypeDRDFrkyghtsKRPKDVE-----RYESREPARNPKWKPehslpPYQEDTDQWNLGPQTYRHAERE 267  human
XP_003362423 328 qetaktgkflkrftdE-ESrvflldrGNTRDKEtpkekGSEKGRAEG--EWEDqealdYFSDKESGKQKFN-DSEGDDTE 403  horse
XP_007484673 308 qetaktgkflkrytdE-ESrvylldrGNTREKEaqkekGTEKGRAEG--EWEDqetldYFSDKEAGKRKFN-DSEGDDTE 383  gray short-tai...
XP_003223334 326 pesskgakflkrytdE-ESrvylldrSNVREKDaqkerGPEKGRTEGEREWEDqdaleYYMDKDSGKQKFI-DSEGEDAE 403  green anole
XP_012818159 314 kehanntkffdrytdE-ENklfpiekCINKEKGtckerGTEKTKKGSSNVWDEhvaldYFLEKEPGNSQFLANSNSEDLE 392  western clawed...
XP_006631434 340 ekpssvstafkkfleEHKNkiqvaewENGREKEqk-maELERDKGNGKAGSFDkgaaySGLKPDYYS-----------KN 407  spotted gar
XP_006007786 331 kelpksgkylkrytdEEETgaylldkSNVKEKDgqkdrGLDKGRVEQDSEWEDqealeYFEQKDSDKLPFLGDSEGEGGE 410  coelacanth
XP_006625948 318 qdlpkvgkylkryteEDGGraylherGNGRDKEhqkdrLQEKGRGEGD--WGDqggidPGVKKESEKVPFLGDSPDPEED 395  spotted gar
XP_011483948 282 edkkaisiafrkfleEQSKkan-ttaEISPKTEae-dgGLEKGNMNGKTSAM-------------------VSDCASGKC 340  Japanese medaka
XP_009290793 277 ddtlalsaafmkfleEQKVkkqasalENNRHKGks-ngDIVCDK--ENGGIFDkg--------iELSHVVDPDNTAEGKC 345  zebrafish

A2AJT9       268 HPEtssatkvSYDYRHKRPK--LLDGDqdfsdgrTQK-------------YCk--------------eEDRKYSFQ---- 314  human
XP_003362423 404 ETE-------DYR---QFRKsvLADQGknfattsHRN-------------TE----------------EEGPKYKS---- 440  horse
XP_007484673 384 ETE-------DYR---QFRKsvLADQGknfatasHRN-------------AE----------------EEGAKYKS---- 420  gray short-tai...
XP_003223334 404 ETE-------DYR---QFRKsvLADQGkgf-sasHRN-------------AE----------------EEGSKYKS---- 439  green anole
XP_012818159 393 EAE-------DYR---QFRKsvLADQGkslssvsNWN-------------CE----------------EEDSKYKT---- 429  western clawed...
XP_006631434 408 EEE-------KYGYDDEFELgsAAEFLkgpqfgsAEA-------------GEdqekrhkvrnqkeremEDEPKHKS---- 463  spotted gar
XP_006007786 411 KPD-------TYR---QFKVssQVEQVksylaetRWN-------------DD----------------DEGNKFKT---- 447  coelacanth
XP_006625948 396 ESQ-------AYRQPYQFKVttQAEQVknypvesRWN-------------VEs--------------qEEGSKYKI---- 437  spotted gar
XP_011483948 341 KEK-------TKG------EvsLKSFLktppflsTEG-------------EE----------------EDEILHRPslkf 378  Japanese medaka
XP_009290793 346 KSA-------KSGDSNKLSKsaPKKAPrnsppfqCEEgeddeemefsdivED----------------MENSPCKS---- 398  zebrafish

A2AJT9       315 --KGP--L--NRE--------LDCfnTGRGRETQDgq---vKEPFKP-SKKDSiactySNKNDVDLRSsnDKWKEkikk- 375  human
XP_003362423 441 --KVSlkG--NRE--------SDGfrEEKNYKLKEtgy-vvERPSTTkDKHKE--------DDKSSERitVKKETqspe- 498  horse
XP_007484673 421 --KVSlkG--NRE--------SDGfrEDKNYKLKEtgy-vvERPSTTkDKHKE--------DDKSSERimVKKETqspe- 478  gray short-tai...
XP_003223334 440 --KIS--MkvNRE--------SEGfrEDKNYKLKEpasyvvERPNIPkDKHKE--------DEKISERt-MKKETqspe- 497  green anole
XP_012818159 430 --KGLtrF--SKE--------GEKfkVVRGSKSAEq-------vAKEkHK------------DKVTQRhsVMKDLlssd- 477  western clawed...
XP_006631434 464 --KIT--I--T-A--------NRDmfDERFNKWDEla---yFPSAKEkLRKEEda-geDDIDDVEEELyrSRKQEraaaa 524  spotted gar
XP_006007786 448 --KIVlkG--DRD--------YDRfgEDRAFKLKGsgf-gaDRPSTSkEKY--------REDDKFLERimIKREPvspe- 505  coelacanth
XP_006625948 438 --KTSk-G--ERD--------YERfgEDRMFKFKNpg---yMLDRLNkDKYGEe----gKGTDKYDERitIKRETvspq- 496  spotted gar
XP_011483948 379 lfKDL--H--NGDesckpkisAQKlfGEAFRKQQN--------AAYSqFTNGEf---dSREEERWVER----KQDkaaa- 438  Japanese medaka
XP_009290793 399 --KVT--M--S----------AREmfENRIRRMQDmt--------------------wDDELEALLLCh--KQERasni- 439  zebrafish

A2AJT9       376 ---------------------egdcRKESNs-S------------------------------SNQLDKsQK--LPDVKP 401  human
XP_003362423 499 ---------------------qvksEKLKDlfDys--------------------------ppLHKNLDaRE--KSTFRE 529  horse
XP_007484673 479 ---------------------qvksEKLKElfDys--------------------------ppLHKNLEaRE--KSTFRE 509  gray short-tai...
XP_003223334 498 ---------------------qvksEKLKElfDys--------------------------ppLHKNPDsRE--KSTFRE 528  green anole
XP_012818159 478 ---------------------elkiEKTKDlfSyn--------------------------ltLHES-NvIE--KNIFRE 507  western clawed...
XP_006631434 525 aaaakkaeasgyrgfspdkapkasrKKEKQgqSps--------------------------ppARKSSEnREreMFNVRR 578  spotted gar
XP_006007786 506 ---------------------qvksEKLSErfDcs--------------------------plLQKTLDlRE--KAASRE 536  coelacanth
XP_006625948 497 ---------------------qakaERFRElfDqs--------------------------plLQKTLDmRE--KAALRD 527  spotted gar
XP_011483948 439 ---------------------isavLAKREltEkfedlspemsfk------kkmmagspsvlaSAAVSSnRE--MFMIRE 489  Japanese medaka
XP_009290793 440 ---------------------laalSKRDQlsGmfrdpspeklssvkrkekttvsssskptlpPRRSSEnREqeMFVVMN 498  zebrafish

A2AJT9       402 SPi--------NLRKKSlTVKVDVkktv--dtfRVassYSTERQMSHDLVAVGRKSENFHPVFEHLDStQNTENKPTGEF 471  human
XP_003362423 530 ESplri-kmiaSDSHRP-EVKLKMapvplddsnRPa-sLTKDRLLASTLVHSVKKEQEFRSIFDHIKL-PQASKSTSESF 605  horse
XP_007484673 510 ESplri-kmiaSDSHRP-EVKLKMapvplddsnRPa-sLTKDRLLASTLVHSVKKEQEFRSIFDHIKL-PQASKSTSESF 585  gray short-tai...
XP_003223334 529 ESplri-kmiaSDSHRP-EVKLKMapvplddsnRPa-sLTKDRLLASTLVHSVKKEQEFRSIFDHIKL-PQASKSTSESF 604  green anole
XP_012818159 508 ESpvkm-rivaTESPLP-EVKLRIitvp-lddgRap-cLDNERLLGSTLIHSVKKVQAFRTIFDHLKV-PFTSRTSPESF 582  western clawed...
XP_006631434 579 DDspprstpaySGKRSA-EVSVRMdpfh-edyaSSsgvLANERRFSRDLVHPSKKDQEFRSIFQHIQS-TQLRRSPSELF 655  spotted gar
XP_006007786 537 ENlpki-kmvpSESYRP-DVKLKMppvsfddpvRPgtsLTSDRLLASALVHSGKKEQGFRSIFDHIKL-PQMYKSSAESF 613  coelacanth
XP_006625948 528 ESpprv-kivpGEASRP-EVKVKIasla-yddpSPgtsLTSDRSLASALVHSTKREQGFRSIFDHIKR-PQAYKNSAESF 603  spotted gar
XP_011483948 490 QDpap----vsSQKPEA-KFHVRMgflg-dslmSSsdiLAEERQLSQDLVLSSKKDPEFRSIFQHVQT-AQSQRSPSELF 562  Japanese medaka
XP_009290793 499 EEspp----raSLKRGScEFSVRMdsls-ddlaRts-vLTNERRNLMDFVHMDKKDLEFQSVLRHLQA-QQFPRSPSELF 571  zebrafish

A2AJT9       472 AQEIITIIHQVKANYFPSPGITLHERFSTMQDIHKaDVNEIPLNSDPEIHRRIDMSLAELQSKQAVIYESEQTLI----- 546  human
XP_003362423 606 IQHIVSLVHHVKEQYFKSAAMTLNERFTSYQK--A-TEEHSARQKSPEIHRRIDISPSALRKHTRLAGEERVFKEenqk- 681  horse
XP_007484673 586 IQHIVSLVHHVKEQYFKSAAMTLNERFTSYQK--A-TEEHSTRQKSPEIHRRIDISPSALRKHTRLSGEERVFKEenqk- 661  gray short-tai...
XP_003223334 605 IQHVVSLVHHVKEQYFKSAAMTLSERFTAYQKSP---EEHSTRQKSPEIHRRIDISPSALRKHTRLAGEERAFKEetqk- 680  green anole
XP_012818159 583 MYHVVSLVHHVKEHYFKGCGKTLNERFTDCLKD---TLDHVSHLRRPEIHRVIDIPPNIPKKHIRIQDEDKAIKKetak- 658  western clawed...
XP_006631434 656 AQHIVTIVHHIKAQHFESSGMTLNERFAMYQRRAA---EMMKPRKSPEIHRRIDVSPSAFRKHSHLFEEMKSSREssskd 732  spotted gar
XP_006007786 614 IQHIVSLVHHVKEHYFKSTGMTLNERFTVYQK--A-TEGQVPRQKSPEIHRRIDISPSALRKHTRLTDEDRLFKEesqkq 690  coelacanth
XP_006625948 604 IQHIVSLVHHVKEHYFKSTGMSLHERFTAYQKAA---EGHEVRQKSPEIHRRIDISPSAFRK-------DRILKEdshk- 672  spotted gar
XP_011483948 563 AQHIVTIVHHVKTQHFPSSGLTLNERFTLYQREAA-EQEMKKSRKSPEIHRRIDVLPSAFKKPPQLFGGVKSSEEgtyks 641  Japanese medaka
XP_009290793 572 AQHIVSIVHHIKAQYFPSSGLTLHDRFAMYQRRAA-EKEFMKQRKSPEIHRRIDVSPSAFKRHSLLFDEVKSSMEnsfkv 650  zebrafish

A2AJT9       547 ---KII-DPNDLRHDIERRRKErlQNEDEHIFHIasaaeRDDQNSSFSKVKNVHTD--GFQK---PTHFIKSNfRkciek 617  human
XP_003362423 682 gdkKLRcDSADLRHDID-------RRRKERSKER-----GDSKGSRESSGSRKQ-E--KTPK---EYKEYKSYkD----- 738  horse
XP_007484673 662 gdkKLRcDSADLRHDID-------RRRKERSKER-----GDSKGSRESSGSRKQ-E--KT-K---DYKEYKSYkD----- 717  gray short-tai...
XP_003223334 681 gdkKLKcDAADLRHDID-------RRRKERSKER-----GDSKGSRESSGSRKQ-E--KMPK---DYKDFKPYkD----- 737  green anole
XP_012818159 659 vekKKKsSLSDQRCDVQ-HKKEhsKER------------VDLTCSRESSNSQKK-E--KPQK---ELKEFKIFkE----- 714  western clawed...
XP_006631434 733 egkKMKtDSMDLRLDIERRKKYssKEREHKRDGM-----RDSGESRGSSLSRERsteksskhhkktkkrkktrersrsss 807  spotted gar
XP_006007786 691 gdkKLRcDSADLRHDID--------RRRKERSRE-----REGSRGSRESSGSRKHE--KSTKdymDYKEYKPYkD----- 750  coelacanth
XP_006625948 673 gekKSRcDAADLRHDId-------RRRKERSRDR-----DDSRGSREPSPSRKLDKlgKEFK---DYKDYKSYkD----- 732  spotted gar
XP_011483948 642 ageKVKgDTMDLRLDIERRKKYscFQNQNQE--------RDVGDSADF--SKELCEq-NLSK---HSNKlngqkrrrsss 707  Japanese medaka
XP_009290793 651 dgkKSKgETMDLRLDIERRKKYliGEREPREEECggrvlRESPDSSkeipteksskkhkkskkskkkrersqssssssss 730  zebrafish

A2AJT9       618 pymnyTT-QRKDI 629  human
XP_003362423 739 -----DSkHKSRE 746  horse
XP_007484673 718 -----DSkHKSRE 725  gray short-tailed opossum
XP_003223334 738 -----DSkQKREq 745  green anole
XP_012818159 715 -----ESkRKKDl 722  western clawed frog
XP_006631434 808 essssshsfkggd 820  spotted gar
XP_006007786 751 -----ESkPKNRE 758  coelacanth
XP_006625948 733 -----DSkHkske 740  spotted gar
XP_011483948 708 ssssssskspkpe 720  Japanese medaka
XP_009290793 731 ssvyneeegeikp 743  zebrafish
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