4HSA


Conserved Protein Domain Family
IL17R_fnIII_D1
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pfam16556: IL17R_fnIII_D1 (this model, PSSM-Id:293164 is obsolete and has been replaced by 435426)
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Interleukin-17 receptor, fibronectin-III-like domain 1
IL17R_fnIII_D1 is the first of two fibronectin 3-like domains on interleukin-17 receptor proteins A and B. The tow fnIII domains are linked and together bind two molecules of IL-17 at one of its receptor-binding interfaces. This allows the other interface to bind to another receptor, thus allowing the IL-17 family of homodimeric cytokines to coordinate two different receptors.
Links
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Statistics
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PSSM-Id: 293164
Aligned: 11 rows
Threshold Bit Score: 257.692
Created: 24-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4HSA_C        17 LNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCV 96  human
XP_008258098  48 LNCTVKNSTCLDDSWIHPRNLTPSSPKDVQIQLHLAYTRSGDLVPVVHVEWMLQTDASILYLEGAELSILQLNTNERLCV 127 rabbit
XP_002743566  48 LNCTVKNSTCLDDSWIHPQNLTPSSPKELQIELRFVRTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCV 127 white-tufted-ea...
XP_003455702  33 LNCEVRETNCLDKRWLKVHDYTPSSPEDLRVSVDVRPDEAGLLQPVLEASWKLKDDGSIHFLNATELHVLVESTNQNLCV 112 Nile tilapia
EDM02034      48 LNCRVENSTCLDDSWIYPRNLTPSSPKNIYLHLNVSSTQHGDLVPVLHVEWTLQTDASILYLEGAELSILKLNTNEQLCV 127 Norway rat
XP_010589082  48 LDCRVRNSMCLDDSWVNPQNLTPSSPKNVQTQLRFVHTRDGDLVPVVHIEWTLQTDASILYLKGAELSVLQQDTNERLCV 127 African savanna...
XP_003979930  33 LQCITSTTNCWDSD-LRPHQYTPSGPEELHVTVDFRRDRRRQLQPVLHISWKLKDDGSIHFLNATELHVLEASTNQNLCV 111 torafugu
XP_001921204  37 VPCTAVFNNCLYKGWLIPSAFTPSAPDDFKVSFDVRENMKGDLEPVIVAEWKAKDDGSISHLNGTELSVMKSSTNEHLCV 116 zebrafish
XP_007259819  36 VPCKAEFNNCFYEEWMKQQDYTPSAPRDLRAKWDVRVDENGDLVPVIVAQWNAMDDGSIFFLKGNQLQVMKLDTSEHLCI 115 Mexican tetra
XP_416389     18 LNCLVGNSTCIERSWLQNQTWTPSAPSSLDVFSDVFRQTDGELLPVLRIEWKVATDASIRYLRGAELAVMQVSSNQQICA 97  chicken
XP_008108678  39 LLCLVRNSTCMDQSWLRSWEWTPSAPSSINVHVGTYFDAERKLVPVLKTEWKVATDASIRFLRGVELTVLQVSSNQQVCV 118 green anole

4HSA_C        97 RFEFLSK-Lr----HHHRR-WRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMS 167 human
XP_008258098 128 KFEFLSR-Lk----HHHRR-WRFSFSNFVVEPGQEYEVTVHHLPKPIPDGDPNHQSRNVLVPGCEDPRMKMTTPCVS 198 rabbit
XP_002743566 128 RFEFLSK-Lr----HHHKR-WRFTCSHFVVDPNQEYEVTVHHLPKPIPDGDPNHQSKNFLVPGCKDTRMKGTAPCMR 198 white-tufted-ear m...
XP_003455702 113 RYSFNKE-Lpm-rsPSGEK-WSFSADMLVLDPGQSYQVSVFNIPKPELHHSSYDIREKVTVPGCKDPNMTNTQFCIE 186 Nile tilapia
EDM02034     128 KFKFLSK-Ls----NHHKR-WRFSFSHFVVDPGQEYEVTVHHLPKPIPDGDPNHKSKTILVPGCEDTEMKMTTPCVS 198 Norway rat
XP_010589082 128 KFEFLSI-Le----HHPKR-WRFNFSNFQVEPGEKYEVIVHHLPKPYPYGDPNHQSSNFSVPGCEDPRMKITPPCVS 198 African savanna el...
XP_003979930 112 RYSFKDK-Lpm-rsPAKEM-WSFSAD-VVVNPDQIYTVSVYNIPKPELNHNNYNVDTLVSVSGCQEKTMKHTQVCIE 184 torafugu
XP_001921204 117 HYNFLKP-FktmrnRAGEK-WSFSLDKVVVDPGSTYVVIVSNLPKPNLDHTFYNVRKTFQVPGCDDPLMRKTKICFE 191 zebrafish
XP_007259819 116 QNTLSER-LsgmrsPTNEL-WAFFVDQMVVDPGFNYSVSISNLPKPNSGQSNYDIRTFVAVPDCSHPVVQKTKFCIE 190 Mexican tetra
XP_416389     98 QFEFQNN-LplqvrPDGGR-WNFTFNRFEVEPGQTYQVTVYHLPKLSVNGDYNCKSVSLTMPDCTDTLMKRTTPCIK 172 chicken
XP_008108678 119 QFDFQNDlLsq-vsPSSGRpWNFSFNQFEVQPGQAYHVTVQHLPILSTRGDHNWKSMPFTVPDCLDPLMKTTVPCVK 194 green anole
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