Conserved Protein Domain Family
ETS_PEA3_N
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pfam04621: ETS_PEA3_N (this model, PSSM-Id:309665 is obsolete and has been replaced by 461371)
PEA3 subfamily ETS-domain transcription factor N terminal domain
The N-terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.
Links
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Statistics
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PSSM-Id: 309665
Aligned: 29 rows
Threshold Bit Score: 232.268
Created: 25-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9PUQ1         6 DGYLDQQVPYTLA---NRSQGNGPLNRLLMATKRKYM-DAELpP-QESEDLFQDLSQLQETWLTEAQVPd---------- 70  zebrafish
XP_006638181   6 DGYLDQQVPYTLA---KKSQGNGPVNRPLMAAKRKFA-DTEL-PpQESEDLFQDLSQLQETWLTEAQVPd---------- 70  spotted gar
XP_002606237   7 keFYDQEVPYMYPqsvPSTDREDDTPPANDGQKRK-----EL---QDSEELFQDLSQLQEAWLAEASCVe---------- 68  Florida lancelet
EDL34067      96 GGYLDQRVPYTFC---SksPGNGSLGEALMVPQGklmdpgSLpP-SDSEDLFQDLSHFQETWLAEAQvp----------- 160 house mouse
XP_013374689   7 ggsLDQQVPYTAC---SklSGNGSLREGLMVPQRklmdpgSLpP-PDSEDLFQDLSHFQETWLAEAQvp----------- 71  long-tailed chi...
XP_017204328   7 GGYLDQQVPYTLC---SksPGNGSLQEALMVPQGklmdpgSLpP-PDSEDLFQDLSHFQETWLAEDAaagalspctspap 82  rabbit
XP_001362921   7 GGYVDQQVPYTFS---SksPGNGSLSRALMVTLGklmdpgSLpP-PESEDLFQDLSQFQETWLTEAQvp----------- 71  gray short-tail...
XP_007259413   6 DGYLDQQVPYTLA---NRSQGNGPLNRLLMAAKRkym-dtELpP-QESEDLFQDLSQLQETWLTEAQvp----------- 69  Mexican tetra
XP_016889662   2 DGYLDQQVPYTLA---NKTLGNGPLNRLLMAAKRkym-dtELpP-QDSEDLFQDLSQLQETWLTEAQvp----------- 65  tongue sole
XP_005794789   6 DGYLDQQVPYPLA---NKSQGNGPLNRLLMAAKRkfm-dtELpP-QESEDLFQDLSQLQETWLTEAQvp----------- 69  southern platyfish

Q9PUQ1        71 ----------SDEQFVPDFHSENsVAFHSPPVKIKKEPQS------PGSDPsQSCSHKQSFSYPNGEQCLY-ASAYEQKR 133 zebrafish
XP_006638181  71 ----------SDEQFVPDFHSEN-LAFHSPPVKIKKEPQS------PGSDPsQSCSHKQAFTYSNGEQCLY-ASACEQKR 132 spotted gar
XP_002606237  69 ----------DEEQFVPDFQAEN-IL--TAPMKVKSEPRSldecprPCSHMvPPGEMSNPDKFDFGEQLFMgNPC----- 130 Florida lancelet
EDL34067     161 ---------dsDEQFVPDFHSEN-LafhsPTTRIKKEPQS------PRTDpaLSCSRKPPLPYHHGEQCLY-SSAYDSPR 223 house mouse
XP_013374689  72 ---------dsDEQFVPDFHSEN-LafhsPTTRIKKEPQS------PRAEpaLSCSRKPPPPYHHGEQCLY-------SR 128 long-tailed chi...
XP_017204328  83 pqppllplptrSVTPAAAGGDGG-VafhsPTTRIKKEPQS------PRTDpaLSCSRKPPLPYHHGEQCLYs-sAYDPPR 154 rabbit
XP_001362921  72 ---------dsDEQFVPDFHSEN-LafhsPTTKIKKEPQS------PRADptLSCSRKPPLSYHHGEQCLY-TSAYDTPR 134 gray short-tail...
XP_007259413  70 ---------dsDEQFVPDFHSENsVafhsPPVKIKKEPQS------PGSDpsQSCSHKQSFSYPSGEQCLY-ASAYEQKR 133 Mexican tetra
XP_016889662  66 ---------dsDEQFVPDFHSEN-LafhsPPVTIKKEPQS------PGSDpsQSCSHKQSFSYPNGEQCLY-ASAYEQKR 128 tongue sole
XP_005794789  70 ---------dsDEQFVPDFHSENsVafhsPPVTIKKEPQS------PGSDpsQSCSHKQTFSYPSGEQCLYa-SAYEQKR 133 southern platyfish

Q9PUQ1       134 aavagAG---------------------GSKSSCPATP-MSPM-QhYSPKPTVGTRQE--SGYMnPPSSSQSHacHSHSY 188 zebrafish
XP_006638181 133 -----AA---------------------GLKSSNPGTP-MSPMhH-YSPKPTITPRPD--TGYMnPTTTAQPV--PGHGY 180 spotted gar
XP_002606237 131 ------------------------------------------DpKlPPLPPAHPPTPK--QDGM-SYPPSTS----STGY 161 Florida lancelet
EDL34067     224 -----QI---------------------AIKSPAPGAPgQSPLqP--------FSRAEqqQSLLrASSSSQSH--PGHGY 267 house mouse
XP_013374689 129 -----QT---------------------AIKSPAPGAPgQSPLqP--------FPRAEp-RGLLrSSGPSQPH--PGHGH 171 long-tailed chi...
XP_017204328 155 -----QI---------------------AIKSPAPGAPgQSPLqP--------FPRTEq-RSFLrASGASQPH--PSHGY 197 rabbit
XP_001362921 135 -----QV---------------------AIKSPTHSAPgQSPLqH--------FPRAE--RSFLrPPGAAPSN--PSHGF 176 gray short-tail...
XP_007259413 134 a----AAstataaagagpgpgagpgagpGPKSSCPGTP-MSPM-PhYSPKPPVGTRPE--TGYMnPPSASQSHpsHSHSF 205 Mexican tetra
XP_016889662 129 a----AG---------------------GAKSSCPGTP-MSPMqQhYSPKPATAGRPD--AGYMnPTATSQPL--PSNTY 178 tongue sole
XP_005794789 134 a----AG---------------------GAKSSCPGTP-MSPMqQhYSPKPAAAGRPD--AGYLnPAATSQPL--PSNNY 183 southern platyfish

Q9PUQ1       189 PM---NPssRF---PSGSAE-MCPPFASQGQALQR-IDPa---Hasgg-------------ggggYHRQH---------- 234 zebrafish
XP_006638181 181 SM---DHssRY---TQPSAE-MCHPYPPPAQAMQR-QHPapggG---------------------YQRQL---------- 221 spotted gar
XP_002606237 162 PHppePP--RY---QRQLSE-PAYRLADPHAFQRQvSDP----M---------------------FQRQVpdhmhfqrsa 210 Florida lancelet
EDL34067     268 LG---EHssVF---QQPVD--MCHSFTSPQGGGRE-PLPa---P---------------------YQHQL---------- 304 house mouse
XP_013374689 172 LG---EHspVF---QQPLD--ACHSFTPSQGGSGD-PLAa---P---------------------YQHPL---------- 208 long-tailed chi...
XP_017204328 198 LG---EHstPSsvfQQPLD--MCHSFTSSQGGGRE-TLPa---P---------------------YQHQL---------- 237 rabbit
XP_001362921 177 MM---EPssIF---QQPPE--ICHSFPSSQGGGRE-PPSa---S---------------------YQPQL---------- 213 gray short-tail...
XP_007259413 206 PI---NHssRF---PAGSAE-MGPPFGPPGQALQR-MHPa---Pagggggg-------gagggggYHRQH---------- 257 Mexican tetra
XP_016889662 179 PI---NT--RY---QGPSGDpMCPQFPPPGQAFQR-MSSapaghgssgagggggpggggggggagYHRQH---------- 239 tongue sole
XP_005794789 184 HI---NNssRF---QGTSADpMCPQFPPPAQAFQR-MPSa---Paghgsggg-----gggggggaYHRQH---------- 238 southern platyfish

Q9PUQ1       235 SDPCLPYpP--------QQTFKQEYMDPLYDR-----AAHINGPQPQR---------------------FPPaHMMVKQE 280 zebrafish
XP_006638181 222 SDPCLPY-M--------QQSFKQEYHDPMYDR-----AGHVAGGAPQR---------------------YPPaHMLIKQE 266 spotted gar
XP_002606237 211 SDTGFQP-PrsegqspfPTNIKQEFPEPMYSR-----A------MAPP---------------------FPP-CPPIKQE 256 Florida lancelet
EDL34067     305 SEPCPPY-P--------QQNFKQeyhdplyeqag-qpassqggvsgHR---------------------YPgaGVVIKQE 353 house mouse
XP_013374689 209 PEPCPPY-P--------HQGFKQeyhdplyeq------agrgglrgHR---------------------YPgaGVVIKQE 252 long-tailed chi...
XP_017204328 238 SEPCPPY-P--------QQSFKQeyhdplyeqag-qpavgqggvsgHR---------------------YPgaGVVIKQE 286 rabbit
XP_001362921 214 PEPCLPY-P--------QQSFKReyhdplye-------qagggggsAR---------------------YPgaGVVIKQE 256 gray short-tail...
XP_007259413 258 SDPCMPY-L--------QQSFKQefmdplyer-----aahmagphpQR---------------------FPpaHMMVKQE 302 Mexican tetra
XP_016889662 240 SDPCMPY-L--------QQSFKQeymdplyeraahmagpvhesgpgQGhghgshstphphqhpqphphrFPpaHMMVKQE 310 tongue sole
XP_005794789 239 SDPCVPY-L--------QQSFKQeyldpmyera----ahmagpgqgQGhghgphqhph--shpqphphrFPpaHMMVKQE 303 southern platyfish

Q9PUQ1       281 PTDYTYEP---DVPGCPSMYHHNEGYSNPQHNS--EGy-------mFENDSRVVPEKFEGEVKQEgGSVFREGAPYQRRG 348 zebrafish
XP_006638181 267 PTDYTYEP---DVPGCPSMYLHNEGYGKPLHNA--DGy-------sFENDSRVVPEKFEGEVKQEaGTVFREGAPYQRRG 334 spotted gar
XP_002606237 257 PRDMGYDGgqaEVPV-WDPYQRRDSMYGPQAAAg-EGfltdsnirsFYDDSC-LPDKLAEGMKPE---LYREAPTYQRRG 330 Florida lancelet
EDL34067     354 RTDFAYDS---DVPGCASMYLHPEGFSGPSPGDgvMGygyekslrpFPDDVCiVPEKFEGDIKQEgIGAFREGPPYQRRG 430 house mouse
XP_013374689 253 QTDFAYDA---DVPGCASMYLHPEGFSGPAAGDraMGygyekalrpFPEDVCvVPERLEGDIKQEgLGAFREGPPYQRRG 329 long-tailed chi...
XP_017204328 287 QTDFAYDS---DVPGCASMYLHNEGFSGPSPGY---Gyekp--lrpFPDDVCvVPEKFEGDMKQEgVGAFREGPPYQRRG 358 rabbit
XP_001362921 257 QTDFAYDS---DVPGCQSMYLHAEGFPGPTPGEgtMGygfekslrpFPEDVCvVPEKFEGDIKQEgLGTFREGPPYQRRG 333 gray short-tail...
XP_007259413 303 PTDYTYEP---------------------------------------------------GEVKQEgGSVFREGAPYQRRG 331 Mexican tetra
XP_016889662 311 PTDYTYEP---DVPGCPSMYHHNEGYPN-PQHSn-EGy-------lFENDSRvVPEKFEGEVKQEgGGVFREGTPYQRRG 378 tongue sole
XP_005794789 304 PTDYTYEP---DVPGCPSMYHHTEGYPNPQHSN--EGy-------lFENDSRvVPEKFEGEVKQEaGGVFREGTPYQRRG 371 southern platyfish
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