Conserved Protein Domain Family
CABIT
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pfam12736: CABIT (this model, PSSM-Id:315418 is obsolete and has been replaced by 463686)
Cell-cycle sustaining, positive selection,
The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologs (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.
Links
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Statistics
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PSSM-Id: 315418
Aligned: 43 rows
Threshold Bit Score: 127.08
Created: 23-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9CU24       272 FPVRVKIMNVVQSESkey-------------pkpLK---------RGQLLTILKTEEVK-KFVASEISQGkKGKCFLVPY 328 house mouse
Q91YX0       267 VPEGPPVFLSPWVSF-------------------LR---------KGQRLCIYGPASPSwRVVASSKSRK-VPRYFMLSG 317 house mouse
A5PF62       274 FPVLAKLSSENH----------------------FRlspdleslfQSKEVIIHHPFKAK-RILASEMCQEs-ARHFLIPE 329 zebrafish
XP_008005300 281 FPIVTEVIEAPQGNHlpq--------------siLQ---------PGKTIVIHKKYQAS-RILASEIRSNfPKRHFLIPT 336 green monkey
XP_007609526 275 FPVRIKVMSVTLSENkal-------------tkpLK---------CGQRLTILRAEDVK-KFVATEISQGrKGRRFLIPY 331 Chinese hamster
XP_003382589 187 FPLRVEVSAGYFGDSec---------------dtFS---------EGDRLNFHFIKQLS-VAV---IETG-TGQLVRVPL 237 Amphimedon quee...
XP_002601284  84 WPIFVRPVSSGEDDFqqamdlselcrspkgtavrIQ---------KGVRLTIHYDVAAR-TVLAGDDN-----TKVAIRE 148 Florida lancelet
XP_014316591 281 FPIVAEVIEAPQGSQlla--------------siLQ---------PGKTIVIHQKCQAS-RILASEIRSHfPKRHFLIPK 336 little brown bat
XP_001509271 281 FPMVAEVIEGPPGTQppn--------------sfLQ---------PGKKIVIHKKYQAT-RILASEIRSSsPKRHFLIPP 336 platypus
XP_006626524 279 FPVVAEIIERPEQIPeel--------------nfLR---------SCKQVIIHHAYEAK-RILASEIRSDv-QRHFLVPL 333 spotted gar

Q9CU24       329 TYQGLVLRRGRY------------FYAVSDV----------AAAM-------------KHGE-LCFQASQ-DYTSYLGS- 370 house mouse
Q91YX0       318 AYQGKLKRRPRE------------FSTAYDL----------LGAL-------------QPGRpLRVVATK-DCDGNEEEn 361 house mouse
A5PF62       330 SYNGRFKRRPRQ------------FSTAYDL----------ERAR-------------SETEeIRVVATK-DFETVYSG- 372 zebrafish
XP_008005300 337 SYKGKFKRRPRE------------FPTAYDL----------EIAKs-------------eKEpLHVVATK-AFHSPHNK- 379 green monkey
XP_007609526 332 TYQGLVLRRGRy------------FYAVSDVa----------aAMqq--------------gqLCFQSCR-DYSSCLEP- 373 Chinese hamster
XP_003382589 238 NSAARFSLIYDPnnnpkeavtgfeFKSVKDVlaqkdmpkiiCATKahgnps-nvshsvQAGElLLINEVK-HGRFG---- 311 Amphimedon quee...
XP_002601284 149 SYRGVFEKRPHv------------YPTVHDLyise--megkVRATktvpvshpdldsvFVDDlITPTGKKgRVPCDRQP- 213 Florida lancelet
XP_014316591 337 SYKGKFKRRPRE------------FPTAYDL----------EIAK-------------SEKEpLHVVATK-AFHPPHEE- 379 little brown bat
XP_001509271 337 SYNGRFKRRPRE------------FPTAYDL----------EIAK-------------SDKEqLHVVATK-DFDSQQEE- 379 platypus
XP_006626524 334 TYKGKFKRRPRK------------FPTAYDL----------EVAK-------------RDKEqLHVVATK-SFESHYNG- 376 spotted gar

Q9CU24       371 --FASFranecflalkksvvsaeihgelhrVE----------------------VLKCLn------------------IA 408 house mouse
Q91YX0       362 pdFSFLavgdrlevlrs---gqvcgtkgqdID----------------------VLVCQrlseqsgeeeedleeiedeAE 416 house mouse
A5PF62       373 --LASVqageefivtkgqscavshngtekvAD----------------------TFECVkv----------------kAE 412 zebrafish
XP_008005300 380 --LSSVs----------------------vGDqflvhhsettevlcegikkvvnVLACEki----------------lKK 419 green monkey
XP_007609526 374 --LASFt----------------------aNEsflalkksvvsaemhgelhrveVLKCLn------------------IA 411 Chinese hamster
XP_003382589 312 ------------------------------GQ----------------------SLICTs------------------IE 321 Amphimedon quee...
XP_002601284 214 --TGHV-------------------------E----------------------YILCTreqr-----------kengQF 233 Florida lancelet
XP_014316591 380 --LSSVavgdqflvhhsqttevlsegikkvVN----------------------VLACEki----------------lKK 419 little brown bat
XP_001509271 380 --LSCVsvgdqflvhhskgnevlgkgtkrtPD----------------------ALTCEri----------------lKT 419 platypus
XP_006626524 377 --LASVsvgdqflvqrretseviyggtrktVE----------------------ALACEki----------------eGK 416 spotted gar

Q9CU24       409 TKAHVKLPLFAVGKFLE--LFDGARPGTLQELCQ--VTRLPCHVRVTSPDPSMTvd-----plYGTKELRIENVIIEQCL 479 house mouse
Q91YX0       417 DKEQILLPLYLSGSFVE--EVNDSRRYNLVDLTA--QYSLPCEVKVVTKDTRHPtd-----plASFPGLRLEEKLTEPFL 487 house mouse
A5PF62       413 GKEPVRLPMCLEGGFME--LVKDKRQYTIAEICR--WFPLPFNVKVSVRDLSLKad-----ilAGTPSLHIEEEISDPCV 483 zebrafish
XP_008005300 420 SYEAALLPLYMEGGFVE--VIHDKKQYPISELCK--QFRLPFNVKVSVRDLSFEed-----vlAATPGLQLEEDITDSYL 490 green monkey
XP_007609526 412 TKAQVKLPLFAEGDFRE--LFADAGPGTLWELCQ--VTKLPCHIRVLSPDRSMArd-----plHGTEELRIENIVVEQCL 482 Chinese hamster
XP_003382589 322 NEKQKRLPENCQGFFST--A-PNHVMLYLPELTK--KFDLPLKVIVSELPSSGNlggrisdslTIREIVTIVSVNKESTI 396 Amphimedon quee...
XP_002601284 234 QAEPIRIPLSMVCPFEEilEKHQMSEFTLRELFRngRPELPIRMALVRGDPKFPdr-----tlAYMSTITVEGMYDETHV 308 Florida lancelet
XP_014316591 420 SYEAALLPLYMEGGFVE--VIHDKKQYQIAELCA--QFHLPFNVKVSVRDLFIEed-----ilVATPGLRLEEAITDSYL 490 little brown bat
XP_001509271 420 SYEMVLLPLYLEGGFIE--VIHDKKRYLLSELCV--QFPLPFNVTVSVRDLSVKed-----vlAGTPGLRLEEEITDSYL 490 platypus
XP_006626524 417 TYEPVRIPMCMDGGFVE--VIHDKKQYHISEICQ--KFHLPFNVKVSVRDLSVSed-----llAAVPGLHLEEEITDPYL 487 spotted gar

Q9CU24       480 IAkdeptl---------ediissADM-------YrewpettfeIP------------IEKISCEVLVVEERSWIADVR 529 house mouse
Q91YX0       488 VV---------------------SLD-------Sqpe----mcFE------------IPPRWLDLTVVEAEGQPAQVA 521 house mouse
A5PF62       484 LV---------------------SNT-------Dlsd---freVP------------VNRTDLIFNVKQRWDGESpkf 518 zebrafish
XP_008005300 491 LI---------------------SDFanptecwE---------IP------------VGRLNMTVQLVSNFSRDAGPF 526 green monkey
XP_007609526 483 VAkdeafledvdasvdiyrewpeTTF-------E---------IP------------VEKSNCEVVVLEERSWMADVG 532 Chinese hamster
XP_003382589 397 IA---------------------TPV-------P---------DEedtqfsndntsmMFDIPVDLEILEVQIIEEKNS 437 Amphimedon queens...
XP_002601284 309 VA---------------------SEY-------D---------NE------------SPDKPVfeiplhaglkvihkv 337 Florida lancelet
XP_014316591 491 LI---------------------SDF-------Anpae--cweIP------------VSRSNMTVQLVSNLSQDTGSF 526 little brown bat
XP_001509271 491 LV---------------------SEF-------Dqpse--cweIP------------VGRLSMSVQLVGSSAEETEPS 526 platypus
XP_006626524 488 VV---------------------TPT-------Dlse---cweFP------------VNRTKISLQLLHRLEKQVRlp 522 spotted gar
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