Conserved Protein Domain Family
Casc1_N
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pfam15927: Casc1_N (this model, PSSM-Id:318198 is obsolete and has been replaced by 464947)
Cancer susceptibility candidate 1 N-terminus
This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.
Links
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Statistics
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PSSM-Id: 318198
Aligned: 33 rows
Threshold Bit Score: 83.1477
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A6H8T2        38 AR----LIAERE-ENERLERERIEQ---------EKQH--I--Le-L---KDRERREDELNELRHILDENHFAVTVWEAE 95  zebrafish
XP_001580967  57 ER----LEQEKL-EAAKKAQQEKEE---------ESRK--R-----A---EQQQRLEEEKEYIKNFRLQKEEKIQKIVAN 112 Trichomonas vag...
XP_001754408  31 ER----LIKEAL-QIVRKELEEKLA---------YEAD--QrwL--E---AERERLAAEADSIIPYYKRQEETREKIEAA 89  Physcomitrella ...
XP_001315841  68 KR----LKLEQL-ERERQQQLAEKAnreaeerrkRERE--M--A--L---AGQQRLQNEETQLKEFREARILNNATIRAD 133 Trichomonas vag...
CBN79221      26 ERkaeiLRAKREaERIRKEAEDAKR---------LKEE--Q--I--AdrtEELERLSNELQEAQDQIAETKERLRWAEKL 90  Ectocarpus sili...
XP_002990212  30 rkaaeeklrleeeerQRIAEEARLA---------WEAE--QarL--K---AEHDRIVGEWESLEPVLKRRREGLAKHEAR 93  Selaginella moe...
XP_002952337  32 laeeerlraeeaerQRLAELERQRL---------ELLE--Qf-L--A---AERARLDVELDELGPLFRQFEHERVRSRNE 94  Volvox carteri ...
XP_003062689  55 ER----IAAEEA-ERARIEAENKAI---------SDLEyeR--I--A---AADAIKAAELAEVTPFLDERRAALEAHRAE 113 Micromonas pusi...
XP_002683425  84 RK----RKEEEE-RKINEERRKKAE---------EEKK--R--L--D---EEKGSFDSEV------IPSFKEKLHTLMIV 134 Naegleria grube...
XP_003388639  28 QR----IREEEE-LRKKEEEERKRK---------EEEE--Q--KlrE---EEQARFVEERAKYDELKTDHQTKIKEWKKT 86  Amphimedon quee...

A6H8T2        96 CREKSKWERYMLCDGSPDPSVQPEINTYISLW----RDDSE-----------NQIQKVLEEC----ALTLEL-------- 148 zebrafish
XP_001580967 113 FEKTEDWELFSQCSHAIDVRSEADVNTFISQL----SEVNE-----------TDINQLFEHI----HLAKVI-------- 165 Trichomonas vag...
XP_001754408  90 ATAKKEWELFMDTSGLPQAAKEATLNTYLENG----YQSLD-----------LDYNEVLKSL----VNIYKI-------- 142 Physcomitrella ...
XP_001315841 134 AAKQTDWETYLQCDHSTNPLDKADVNSFITLW----REAED-----------TNMPVLFEHI----ATVVKL-------- 186 Trichomonas vag...
CBN79221      91 EAVQSSWETYTKCDPRPDAASEKALNTFLSQG----ADEEV-----------PELDQAMERCvygeSIAADL-------- 147 Ectocarpus sili...
XP_002990212  94 YDGAAEWKRYVEPGPLPYAGNDPSMNGYLNVM----AEGYD-----------KDINDVMRTL----TDIYSVrylrascd 154 Selaginella moe...
XP_002952337  95 ALEAAEWERFLRCVRVPAPRQRVEVNEFLLRMnessREEDS-----------RSLEEAFLTC----EDCRTM-------- 151 Volvox carteri ...
XP_003062689 114 VKDAYEWERHLATSALPDPQREKEINTYEMAI----TDEE------------------TRLL----GPALEL-------- 159 Micromonas pusi...
XP_002683425 135 AKEEDEWNKFVNCENLPKLDDDVDMNNFISSW----RDLNElalkkeirninEDFAMVVEGC--------KV-------- 194 Naegleria grube...
XP_003388639  87 EKESKEWEHYVSCNKLPLPSSQQSLNTYFSTF----SERRPp----------ATMSDTLKRL----RELFQV-------- 140 Amphimedon quee...

A6H8T2       149 ------EKEL---EFLLGDG---------PEPSIAEQY----QETLLSLQNLIHYKLNQATEELLKFANYNSDIDTGNMQ 206 zebrafish
XP_001580967 166 ------ENQL---RER-SEK---------AQLANRVPLytrcNRQIDTLQQLINQKIENITVNHLAFSDKFSGAKGDVQI 226 Trichomonas vag...
XP_001754408 143 ------SNEA---VELAL-Q---------EDQKGNVNEatkyRGFMLKLEKMGKFRMDQTTNYLLQKSYAVY-RDTEKSI 202 Physcomitrella ...
XP_001315841 187 ------INQL---TN-LRYT---------AEVAAINEDvtrfSEHINDIRSIISQKIELLTQHHLMFSDKYTGAKSEVLL 247 Trichomonas vag...
CBN79221     148 ------LNDI--------GQ---------SLENGDISRmarnEEFLELLRGLSFDKIDFATAHLLSHWDSLSGGDEDFDR 204 Ectocarpus sili...
XP_002990212 155 khdtafLSKIfagAEELALV---------EEQKGRPQLvekyHDYMRRLEELANRRLNHNTAYLLEKSHDYYKRTNECSL 225 Selaginella moe...
XP_002952337 152 ------VLET---RQALLETrnrvvgsggPEEEASRKa---lESDIRELYAIINARIDRFTAAVLHHCDEYANERNEIQL 219 Volvox carteri ...
XP_003062689 160 ------AVDN---EKIVNEGdty---rywAIAEGRDAFadavGGFQKRIRALTDVVIDRSTAGIMHTADEYQDENGEIIV 227 Micromonas pusi...
XP_002683425 195 ------MNEI---EYLLVE----------SIAQSKKdlethctKYLNYLSNCIVQTMDDATAHIMQYFDKYLSSENDQYQ 255 Naegleria grube...
XP_003388639 141 ------LEEL---------E---------KEVQDEDnsddaihHYIDKVSYVLLil------------------------ 172 Amphimedon quee...

A6H8T2       207 TVVKDSNITLCLWANLN-KNPR 227 zebrafish
XP_001580967 227 NGGSD-DITYGMWVNLS-KNPR 246 Trichomonas vaginalis G3
XP_001754408 203 VTERIGDWKLALWINHV-KNPR 223 Physcomitrella patens
XP_001315841 248 NAES-SGYQYGLWVNLA-KNPR 267 Trichomonas vaginalis G3
CBN79221     205 TCMTAGGIRVGVWVNVSlKGFR 226 Ectocarpus siliculosus
XP_002990212 226 FSGQAG-WKLALWANHA-KNPR 245 Selaginella moellendorffii
XP_002952337 220 GHV-AGTFKWGVWVNTA-KNPR 239 Volvox carteri f. nagariensis
XP_003062689 228 FDSR-EGFKYVLWLNHV-KNPR 247 Micromonas pusilla CCMP1545
XP_002683425 256 KVHPF--IKYGIWTNIS-KNLY 274 Naegleria gruberi strain NEG-M
XP_003388639     ----------------------     Amphimedon queenslandica
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