Conserved Protein Domain Family
RB_B
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pfam01857: RB_B (this model, PSSM-Id:366845 is obsolete and has been replaced by 460363)
Retinoblastoma-associated protein B domain
The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain. The B domain has a cyclin fold.
Links
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Statistics
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PSSM-Id: 366845
Aligned: 88 rows
Threshold Bit Score: 116.089
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_018653203  814 SIAIFFRQTYQVASLRLRDLCERLSLTRE-LMAKIWTCIEQVIVHETELLRDRCLDQVIMCCIYGICKLVLyRPLTFVDI 892  Schistosoma m...
CBI20795      726 GINIFFSKIIKLAAVRINGMVERLQLSQQ-MRENVYCLFQQILNRRTSLFFNRHIDQIILCCFYGLAKISQ-MNLTFREI 803  wine grape
B9GLX8        755 GINVFFTKINKLAAVRINGMIEKLQPSQQhIRENVYRLFQLILSHQTSLFFNRHIDQIILCCFYGVAKISK-LNLTFREI 833  black cottonwood
Q9LKZ3        729 GINIFFTKINKLAAVRINGMVERLQLSQQ-IRESVYCFFQHVLAQRTSLLFSRHIDQIILCCFYGVAKISQ-MSLTFREI 806  thale cress
EEF49309      363 AINVLFSKMAKLGAIRTQSIAERLKLSKQ-FREKVYFLFQQILNQRTTLFFNRHMDQIVLCCFYGLAKMSG-VNLTFKQI 440  castor bean
XP_019080588  331 GIKLLFEKVAKLAAVRINHLTLRLKPLQP-IREIVYGLFHRILNQKTALCFNRHVDQIILCCFYIIVKDSK-LELTFKEI 408  wine grape
ERN06336      737 GISIFFRKVLKLAAIRIKSLCERLQQPNN-VMESVYSLVQQIINRQTVLFFNRHIDQIILCSFYGVSKIFH-LNLTFREI 814  Amborella tri...
XP_009403804  736 VIRVFCNKILKLAAIRIKSLGEKLQLSQQ-ILEYVYRMFQQILCQRTSLFFNRHIDQIILCSLYGVAKVCR-VDLTFKSI 813  wild Malaysia...
XP_024310563  604 GVNIFFSKILKLAAIRIRNLCERLRHVEQ--TERVYNIFKQILDQQTTLFFNRHIDQLILCCLYGVAKVSQ-LTLTFKEI 680  stiff brome
RCV32065      734 GIGVFFSKIAKLAAIRIRSLCERLQLSQQ-VLERVYSLVQQILTQQTALFFNRHIDQIILCSIYGVAKISQ-LELSFKEI 811  foxtail millet

XP_018653203  893 VQVYRMQPQSYRDIYRRVLINRVSYGRGN--TEERGDLSRFYNVIFLPQMK 941  Schistosoma mansoni
CBI20795      804 IHNYRKQPQCKPQIFRSVFVDWSSARRNGktGKEHVDIITFYNEIFIPAVK 854  wine grape
B9GLX8        834 IYNYRRQPHCKTLVFRSVFVDWSSARHNGrtGQDHVDIITFYNEIFIPAAK 884  black cottonwood
Q9LKZ3        807 IYNYRKQPQCKPLVFRSVYVDALQCRRQGriGPDHVDIITFYNEIFIPAVK 857  thale cress
EEF49309      441 YDNYMKQPQCRSQIFWSV---SGNHERNGg---QYAEMITFYNRIFLPSVK 485  castor bean
XP_019080588  409 KDSYVKQPQHGPQVVSHVFVNRSPAHGNGknREDHIDIVAFYNEIFLWAVK 459  wine grape
ERN06336      815 IFNYRKQPQCKPQVFRSVFVDWPSTSRNGkaGQEHVDIIRFYNELFILAVK 865  Amborella trichopoda
XP_009403804  814 VNYYKTQPQCKPHVVKNIFVAVPSANRNGrmVQEYVNIITFYNQIFIPSVK 864  wild Malaysian banana
XP_024310563  681 VTNYKREQQCKPEVFRSVFVG--STNRNGglGSRHVDIIVFYNEVFVPAVK 729  stiff brome
RCV32065      812 IFGYRKQPQCKPQVFRSVYVHWPPRSRNGkmGEDHVDIITFYNEVFIPAVK 862  foxtail millet
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