Conserved Protein Domain Family
bHLHzip_TFE3
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cd18928: bHLHzip_TFE3 
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins
TFE3, also termed Class E basic helix-loop-helix protein 33 (bHLHe33), is a bHLHzip transcription factor that is involved in B cell function. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF.
Links
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Statistics
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PSSM-Id: 381498
Aligned: 3 rows
Threshold Bit Score: 185.253
Created: 18-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences.
  • Comment:Based on the structure evidence that Mus musculus Mitf (4ATI) binds DNA.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      ## ##  ##   #                    ##                               
P19532       337 EAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSL 416 human
NP_001038531 217 EARAFMKERQKKDNHNLIERRRRFNINDRIKELGALIPKSTDPEMRWNKGTILKASVDYIRKLQKEQQRAKEIEMRQKKL 296 zebrafish
XP_008116586 309 EAKAFLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPEMRWNKGTILKASVDYIRKLQKEQQRSKEMEIRQRKL 388 green anole

Feature 1                   
P19532       417 EQANRSLQLRI 427 human
NP_001038531 297 EQSNQALILRI 307 zebrafish
XP_008116586 389 EQANRSLQLRV 399 green anole

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