5MR4,6GL7,4UX8,4UX8,2GH0,5VZ4,5VZ4


Conserved Protein Domain Family
GDNF

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pfam02351: GDNF (this model, PSSM-Id:396776 is obsolete and has been replaced by 460537)
GDNF/GAS1 domain
This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.
Statistics
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PSSM-Id: 396776
Aligned: 131 rows
Threshold Bit Score: 33.6599
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5MR4_C        251 CLDLRGVCRTDHLCRSRLADFHANCRASY--QTVTSCPAdNYQACLGSYagmigfdmtPNYVDSSPTgiVVSPWCSCRGS 328
XP_792667      29 CTDARRACERDDFCSLGLIAIQHHCGNVDg-RSCEATPS-GLVNCLMML------------QDARIY--RVFASCYCDPS 92  purple sea urchin
EKC42622      121 CLTAHLICDTDSTCAAALNYYHSLCGNLKdaGWCS-------ERCNESI---------NILYQTKYA--MKLQKCKCDKT 182 Pacific oyster
XP_012551939  112 CSLSQLICLADAQCSTALQYYHHLCRSMFrgRKCS-------KKCINSI---------EILRKQEKA--AALTVCQCDG- 172 domestic silkworm
50_pfamImport   1 CEVAQWICSADTLCSTALMYYNMNCRSMFagRKCS-------PRCKNSI---------EILRRQEKA--AKLDSCVCNG- 61 
XP_008195285  111 CRVAQWICAADALCSTALEYYNHYCRAMFhgKKCT-------PRCNNSI---------SILRRQEKA--AKLTMCKCDG- 171 red flour beetle
AAI25919      131 CTEARKQCEKDPECKTAMLDYLYHCRKLFggNRCS-------DDCRTLI---------ANMRSNPKA--QLLDTCVCDG- 191 zebrafish
XP_006014263  131 CTQARRECEKELKCSMSLSKYLSHCGNLFngLQCT-------ESCKAVI---------EDMLSVPKA--VLLNECVCDG- 191 coelacanth
XP_011492102  114 CMEARQRCEENPVCHTSLAAYLAHCGQLFngRRCS-------SKCKATI---------QQMLSIPNG--ELLNQCIC--D 173 Japanese medaka
ESO00667      167 CLWRRRWCSRESRCLESLATFRAECRENKntKRCLPNN---WSACHLSL-----------ISLRKHS--RDLLSCQCGHF 230 Helobdella rob...
5MR4_C        329 GNME--EECEKFLRDFTENPC 347
XP_792667      93 SPEF--AACHHQQRLTISNPC 111 purple sea urchin
EKC42622      183 -TDD--FNCFELQQNTdyclk 200 Pacific oyster
XP_012551939  173 -TED--YDCPTMQENL----A 186 domestic silkworm
50_pfamImport  62 -RED--YNCNTIRTNM----E 75 
XP_008195285  172 -LED--YDCPAIQRNM---EK 186 red flour beetle
AAI25919      192 -NER--TTCEYVKFSM--KNL 207 zebrafish
XP_006014263  192 -LER--PICESLKENM---Ak 206 coelacanth
XP_011492102  174 GVER--PFCEVVKENM---SK 189 Japanese medaka
ESO00667      231 KNQQlnKKCHKFQQNLLSNAC 251 Helobdella robusta
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