5TOD


Conserved Protein Domain Family
SMP_C2CD2L
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pfam18696: SMP_C2CD2L (this model, PSSM-Id:408473 is obsolete and has been replaced by 465835)
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Synaptotagmin-like, mitochondrial and lipid-binding domain
This is a lipid transport domain found in phospholipid transfer proteins such as C2CD2L-like (also known as TMEM24). The TMEM24-SMP domain is shown to bind glycerolipids with a preference for phosphatidylinositol (PI).The bound PI is then transferred to the plasma membrane (PM) where it is converted to phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] to replenish pools of this lipid hydrolyzed during glucose-stimulated signaling. PI(4,5)P2 is required for Ca2+-dependent exocytosis hence, the SMP domain of TMEM24 is essential for sustaining the intracellular Ca2+ oscillations that trigger bursts of insulin granule release and hence insulin secretion. The SMP domain belongs to a superfamily of lipid/hydrophobic ligand-binding domains called TULIP for (tubular lipid-binding proteins) it adopts TULIP fold with two alpha helices and a highly curved antiparallel beta sheet forming a cornucopia-like structure.
Links
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Statistics
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PSSM-Id: 408473
Aligned: 38 rows
Threshold Bit Score: 162.795
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5TOD_F        31 WQRAWVRALNEQACRNGSSIQIAFEEVPQLPP-RASISHVTCVDQSEHTXVLRCQLSAEEVRFPVSVTQQSPAAVSXETY 109 human
XP_015193045 109 WQRTWVRALNEQACRNGSSIQITF-EDSLQLPsSASISHVTCTDQSEQSMVLQCHCAVDTVAFPVTVTQQSPAAVSLDTY 187 spotted gar
Q08BC9       105 WQRAWVRALNEQACRQGSSIQITF-DDSLQLPtSASIDRVTCTDQSVRSMVLQCNCSVDTVSFPVTVTQQSPATVSMDTY 183 zebrafish
XP_013127769 102 FQRTWVKALNEQACRHGSSIQITF-DSSLQISaASAIESVSCTDQSANRMILHCNCSVDRVTLPVTVTQQSPAAISMDTY 180 Nile tilapia
XP_014912253 111 WQRTWVKALNEQACRHGSSLQITF-DSSLQLTaGSAIDSVTCTDQSANKMVLRCKCWVDTLTFPVTVTQQSPAAVSMDTY 189 sailfin molly
XP_011481713 101 WQRTWIKALNEQACRHGSSLQITF-DSSLQLSvAAAIQTVTCTDQSATRMVLHCNCWVDTLMFPVTVTQQSPATVSMETY 179 Japanese medaka
XP_016159295  80 WQRAWVRALNSQARRHGSSVQITF-EEGHQLPqAANISCVTCKGQSDHGIVLCCHLSAEAVKFPVSVTQQSPVAVSVDTY 158 Collared flycat...
XP_006119780  90 WQRAWVRALNEQACRHGSSVQITFEENP-QLPaAVNISHVTCTDQADHSMVLHCHLSANAVKFPVSVTQQSPAAVSMDTY 168 Chinese soft-sh...
XP_005988230  98 WQKVWINALNEQACRIGSSVQITFEESPQLMS-SSSVSQVTCMDQSERSMVLQCHVSADAVRFPVSVTQQSPAAVSMDTY 176 coelacanth
XP_009303774  74 WRRAWFRSLNEEACRSQSGIQLTFEDDGVQSS-ELAVDQISSFTKTRGQKNVLCQVVGNKLQFSLSAFPSSTTSQTPLRY 152 zebrafish

5TOD_F       110 HVTLTLPPTQLEVNLEEIPGeGLLISWAFTDRPDLSLTVLPKLQAR--ERGEEQVELSTIEELIKDAIVSTQPAX 182 human
XP_015193045 188 QVAMAPMEAQLVICLEEVEEeGLLVSWTFSQQPLLSLTVTPRRIQK--DVNDGKVDLGTIGELVRDTIVSTQPAM 260 spotted gar
Q08BC9       184 QITMDPMQAQLQVCLEEVEEeGLLVSWTFSKQPHLSLTVTSRQRAQk-EGSDVEVDSDMIAALVEDTLYTTHPAM 257 zebrafish
XP_013127769 181 QITIAPVVAKVVACLEEVEDeGLLISWSLSKQPSFSLTVSPCKLQR--RGTEGEADIDTIKGLIEDTLFSTQPAM 253 Nile tilapia
XP_014912253 190 QITTAPMMAKVDVSLEEVEDeGLLISWTFSKQPSFSLTVSPCKLQR--QRSEATADLDMIKGMVEDTLFSAHPAM 262 sailfin molly
XP_011481713 180 QVTTAPMVAKVVVSLEELENeGLLMSWNLSKQPSFSLNVLPCKQQT---ASGGEADLHMIRGLIEDTLFSTQPAM 251 Japanese medaka
XP_016159295 159 HVTLAVLQAQVEIHLEEIQNeGLLVSWTFKDRPDLDFLVLPR-LEL--PADERRADLSTIKDLIEDTIVSTKPAM 230 Collared flycatcher
XP_006119780 169 QVTLALLQAQVEIRLEEMKNeGLLVSWTFKDRPDLNLSVVPKLHPR--EKNDGKVDLSTIKDLIEDSIVSTQPAM 241 Chinese soft-shelled...
XP_005988230 177 QVSLTLQRTQLEICMEEVENeGLLVSWTFRERPNLSVTVSPKLQQR--EENDGKVDVSTIQELIEDTIVSTQPAM 249 coelacanth
XP_009303774 153 SVKISPLHLQLALQMKEVNG-EVEISWRVLHLDSVDLQLMPSFAQGdcQSLSDAAVTDR----LRQVLNGAQASV 222 zebrafish
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