Conserved Protein Domain Family
RasGAP_DAB2IP
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cd05136: RasGAP_DAB2IP (this model, PSSM-Id:88576 is obsolete and has been replaced by 213338)
The DAB2IP family of Ras GTPase-activating proteins includes DAB2IP, nGAP, and Syn GAP. Disabled 2 interactive protein, (DAB2IP; also known as ASK-interacting protein 1 (AIP1)), is a member of the GTPase-activating proteins, down-regulates Ras-mediated signal pathways, and mediates TNF-induced activation of ASK1-JNK signaling pathways. The mechanism by which TNF signaling is coupled to DAB2IP is not known.
Links
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Statistics
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PSSM-Id: 88576
Aligned: 8 rows
Threshold Bit Score: -1
Created: 30-May-2007
Updated: 9-Mar-2011
Structure
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Aligned Rows:
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putative
Feature 1:putative GAP/RAS interaction site [polypeptide binding site]
Evidence:
  • Citation:PMID 8955277
  • Comment:based on the interaction between human p120GAP and Ras
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      #                                    #   ####      
CAK11352      365 ELYKEFAEYVTNNYrtLCGVLEPLlsaksKEEVACALVHILQSTGKAKDFLSDMAMCEVDrfmdreHLIFRENTLATKAI 444  zebrafish
13959419      299 EQYKEFAEFVTSNYtmLCSVLEPVisvrnKEELACALVHILQSTGRAKDFLTDLVMSEVDrcgehdVLIFRENTIATKSI 378  human
NP_573240     422 NVYGNFLTYLKENYkrVCETLEPVigvkaKEDIGQALVLLMHAQGLAGAFLTDVVALDLLrvg-dqRLTFRGNSLATKSM 500  fruit fly
XP_001120165  561 QVYQEFLEYLKTDYasLCEKLEPVigvkaKEDIATALVAVMQREKKAPQFLADLVMMDIHrid-deRLTFRGNSLATKAM 639  honey bee
BAB15778      161 ERYKELAEFLTFHYarLCGALEPAlpaqaKEELAAAMVRVLRATGRAQALVTDLGTAELArcggreALLFRENTLATKAI 240  human
33112297      535 RAYDNLLETLCYNYlpLCEQLEPVlnvrdKEDLATSLVRVMYKHNLAKEFLCDLIMKEVEkld-ndHLMFRGNTLATKAM 613  Caenorhabditi...
XP_426625     439 EQYKEFAEFVTSNYtmLCSVLEPVisvrnKEEMACAMVHILQSTGRAKDFLTDLVMSEVDrcgehdVLIFRENTLATKAI 518  chicken
XP_001338932  289 ERYKEFAEYVTVNYvdMCSSLEPLlnvreKEELAGALVHVLQSIGKAKEFLIDLGSAEVQrlgeneALIFRENTLATKAI 368  zebrafish

Feature 1         #                                                                               
CAK11352      445 EEFLKLIAHRYLKDTIGEFIRALyeseenCEVDPMRTp---pSVLADHQANLRMCCELALCKIINSHCVFPRELKEVFAS 521  zebrafish
13959419      379 EEYLKLVGQQYLHDALGEFIKALyesdenCEVDPSKCs---sSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFAS 455  human
NP_573240     501 EAFLKLTGEQYLQDTLSAPINELiqserdCEVDPTKTsgssaGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFAT 580  fruit fly
XP_001120165  640 EAYLKLTGDRYLQETLGAVVRGAveg-gdCEVDPLKVas--vAALHKQQQNLRNAVELAWSRILASHAHFPLELRECFRI 716  honey bee
BAB15778      241 DEYMKLVAQDYLQETLGQVVRRLcastedCEVDPSKCp---aSELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSS 317  human
33112297      614 ESFMKLVADDYLDSTLSDFIKTVlqcedsCEVDPQKLgnvsnSSLEKNRALLMRYVEVAWTKILNNVHQLPKNLRDVFSA 693  Caenorhabditi...
XP_426625     519 EEYLKLVGQKYLHDALGEFIKALyesdenCEVDPSKCs---sSELTDHQSNLKMCCELAFCKIINSYCVFPRELKEVFAS 595  chicken
XP_001338932  369 DEYMKLVGQKYLIDTLGDFIARLynggenCEVDPLKCs---pSDLPINQRHLKETCEDVVKRITDMQESFPAELNDIFSS 445  zebrafish

Feature 1                        #       ##  ##                           #      # #    ##        
CAK11352      522 WRVRCAERGRediADRLISSSLFLRFLCPAIMSPSLFNLTqeypseRTSRTLTLIAKVVQSLASFSKFsgKEDYLGFMNE 601  zebrafish
13959419      456 WKQQCLNRGKqdiSERLISASLFLRFLCPAIMSPSLFNLMqeypddRTSRTLTLIAKVIQNLANFAKFgnKEEYMAFMND 535  human
NP_573240     581 FRERLQQLGRqdmADNLISASIFLRFLCPAILSPSLFNITselpsaRATRNLTLVAKTLQTLANFTRFqgKENFMEFLND 660  fruit fly
XP_001120165  717 FRERLADMGRediADNLISASIFLRFLCPAILSPSLFNITheypneKAARNLTLVAKTLQTLANFTRFqgKENFMEFMND 796  honey bee
BAB15778      318 WREACKERGSevlGPRLVCASLFLRLLCPAILAPSLFGLApdhpapGPARTLTLIAKVIQNLANRAPFgeKEAYMGFMNS 397  human
33112297      694 LRCRLEAQNRealADTLISSSIFLRFLCPAILSPSLFNLVseypspTNARNLTLIAKTLQNLANFSKFggKEPHMEFMNE 773  Caenorhabditi...
XP_426625     596 WKQQCLSRGKqdiSERLISASLFLRFLCPAIMSPSLFSLMqeypddRTSRTLTLIAKVIQNLANFAKFgnKEEYMAFMND 675  chicken
XP_001338932  446 WVSDCEDRGQqdiGQRLISASLFLRFLCPAILSPSLFGLTqpypetNTLRTLTLTAKVIQNLANFTLFgeKEEYMFFMND 525  zebrafish

Feature 1                                                                                         
CAK11352      602 FLEMEWGSMQQFLYEISNlecvsna----gafegyiDLGRELSILHSllwEVMAQLSKDai-------lkLGPLPRLLND 670  zebrafish
13959419      536 FLEHEWGGMKRFLLEISNpdtisnt----pgfdgyiDLGRELSVLHSllwEVVSQLDKGensflqatvakLGPLPRVLAD 611  human
NP_573240     661 FLEQEAARMQQFLEIISTrpehpapds-ildwagyiDQGKQLSILHSllsESLAKLPEArq-------heLDPLQHILDE 732  fruit fly
XP_001120165  797 LLEREAPSMKNFLQLISSplpkdapannslefdgyiDLGKQLSLLHAllrESLVTITSFsss------lpPSRLPEILER 870  honey bee
BAB15778      398 FLEEHGPAMQCFLDQVAMvdvdaap----sgyqgsgDLALQLAVLHAqlcTIFAELDQTtr-------dtLEPLPTILRA 466  human
33112297      774 FVDREWHRMKDFLLRISSesksgpe----knadaivDAGKELSLIATyleEAWTPLLQEkn-------gnKHPLSNVKSV 842  Caenorhabditi...
XP_426625     676 FLEHEWGGMKRFLLEISNpdtisnm----pgfegyiDLGRELSVLHSllwEVVSQLDKGensflqatvakLGPLPRILAD 751  chicken
XP_001338932  526 FLTQHWEPMRDFLQKVSNpeseitm----srfdgyvDLPLRLAVLHNllvDIISVMKQDqi-------dnLHPLPRILNQ 594  zebrafish

Feature 1            
CAK11352      671 ISV 673  zebrafish
13959419      612 ITK 614  human
NP_573240     733 ISR 735  fruit fly
XP_001120165  871 ISI 873  honey bee
BAB15778      467 IEE 469  human
33112297      843 LSE 845  Caenorhabditis elegans
XP_426625     752 ITK 754  chicken
XP_001338932  595 ITE 597  zebrafish

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