2NPT,1WI0


Conserved Protein Domain Family
PB1_Map2k5
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cd06395: PB1_Map2k5 
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PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 interacts with the PB1 domain of another members of kinase cascade MEKK2 (or MEKK3). A canonical PB1-PB1 interaction, involving heterodimerization of two PB1 domain, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. The Map2k5 protein contains a type I PB1 domain.
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Statistics
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PSSM-Id: 99717
Aligned: 5 rows
Threshold Bit Score: 165.044
Created: 27-Feb-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PB1 interaction
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:PB1 interaction surface [polypeptide binding site]
Evidence:
  • Structure:2NPT; Human MAP2K5 and MAP3K3 form an asymmetric heterodimer
    - View structure with Cn3D
  • Comment:Map2k5 contains a type I PB1 domain with a OPCA acidic amino acid motif while MEKK2/3 contains a type II PB1 domain
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                       # # #        #                   
2NPT_A        15 LVIRIKIPNsGAVDWTVHSGPqLLFRDVLDVIGQVLPEattTAFEYEDEDGDRITVRSDEEMKAMLSYYYstvmeqqvng 94  human
1WI0_A        17 LVIRIKIPNsGAVDWTVHSGPqLLFRDVLDVIGQVLPEattTAFEYEDEDGDRITVRSDEEMKAMLSYYYstvmeqqvng 96  house mouse
XP_786275      6 LVIRIKTQHgEDVDWTVQLGQ-LSFHEVLEVIAQVLQDntpAAFEYEDEDGDRITVRSDDEMEAMINYYLsllaecearr 84  purple urchin
NP_001084729  17 LVIRIRIPDgGAVDWTVQPATqLLFRDILDVIGQVIPDattTAFEYEDEDGDRITVRSDEEMKAMLSYYCsmvleqqgsg 96  African clawed ...
NP_001107789  17 IVIRIKTPV-GDMDSPVDSPShLNFNDLLAAIRDAMPEatvTAFEYEDEVGDRITVRSDDELKAMLSYYCntvmeqrfng 95  zebrafish

Feature 1                   
2NPT_A        95 qliEPLQIFPR 105 human
1WI0_A        97 qliEPLQIFPR 107 house mouse
XP_786275     85 vmaPPLNIYPQ 95  purple urchin
NP_001084729  97 plmEPLQIYPR 107 African clawed frog
NP_001107789  96 llpEPLQIFPR 106 zebrafish

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