3K1L,6SRI


Conserved Protein Domain Family
FANCL_C
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pfam11793: FANCL_C 
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FANCL C-terminal domain
This domain is found at the C-terminus of the Fancl protein in humans which is the putative E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2.
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Statistics
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PSSM-Id: 463350
Aligned: 7 rows
Threshold Bit Score: 108.66
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3K1L_A       307 EELRCNICFAYRLd--------GGEVPLVSCDNAKCVLKCHAVCLEEWFKTLMDGKTFLEVSFGQCPFCKAKLSTSFA 376 fruit fly
XP_001315697 268 TEIECPICFCERF---------GGELPEIVCENPKCAKHYHRSCLVDWLRENRKMEQSFHCIYGTCPNCGAKIQVDDS 336
BAH20121     221 QQVECGICYAQFLptdeelgarSGTRTDYTCENISCNKSFHSLCLTDWLRSITTTRQSFDVLFGNCPYCSDPVAVKTS 298
Q9CR14       303 FSMDCGICYARHL---------NGAIPDQVCNNPQCGQPFHEICLYEWLRGLSTSRQSFNVFFGDCPYCSKPITLKMS 371 house mouse
6SRI_q       301 FTKDCGICYAYRL---------NGTTPDQVCNEPRCGQPFHQACLYEWLQGLPSSRQSFNVIFGECPYCNKPLTVKSS 369 chicken
EDO38136     301 FSMECGICYAYRL---------NDTIPDKACDDPRCGQPFHRDCLYEWLRSLPSSRQSFNMVFGECPYCSKPITVKMT 369
XP_017949335 295 FSMDCGICYAYRL---------DSAIPDQVCDDPRCGQPFHQACLYEWLRGLPSSRQSFNIIYGECPYCNKVQqkfll 363 tropical clawed frog
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